Irinotecan Hydrochloride CAS 100286-90-6 Tsafta ≥99.0% (HPLC) API USP Standard High Tsabta
Samar da Mai ƙera Irinotecan da Matsakaici masu alaƙa:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Sunan Sinadari | Irinotecan Hydrochloride |
| Makamantu | Camptothecin II;CPT-II |
| Lambar CAS | 100286-90-6 |
| Lambar CAT | RF-API50 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | Saukewa: C33H39ClN4O6 |
| Nauyin Kwayoyin Halitta | 623.15 |
| Matsayin narkewa | 250-256 ℃ (Dec.) |
| Yanayin Ajiya | Karkashin Zazzabi |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari ko Kashe-Farin Foda |
| Solubility | Mai narkewa a cikin ruwa da methanol, dan kadan mai narkewa a cikin chloroform, ethanol |
| Gano IR | Bakan shayarwar infrared na samfurin gwajin yakamata yayi daidai da na ma'aunin tunani |
| Bayanin HPLC | Lokacin riƙewa na babban kololuwar samfurin mafita yakamata yayi daidai da na ma'aunin tunani. |
| Ganewa | Ya dace da buƙatun gwaje-gwaje don amsawar Chloride mai kyau |
| Danshi (KF) | 7.0% ~ 9.0% w/w |
| Ragowa akan Ignition | ≤0.10% |
| Karfe masu nauyi | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| Irinotecan Abubuwan da ke da alaƙa A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Abubuwan da ke da alaƙa da Irinotecan B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Duk Wani Tsaftar Da Ba A Fayyace Ba | ≤0.10% |
| Jimlar ƙazanta | ≤0.50% |
| Residual Solvents (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Ether: | ≤100ppm |
| Ethyl acetate | ≤2000ppm |
| Benzene | ≤2pm |
| Bacterial Endotoxins | ≤0.29 EU/mg Irinotecan |
| Iyakar Microbial | Jimlar Ƙididdigar Ƙwararrun Ƙwayoyin Ƙwallon Ƙirar Ƙira: <1000 cfu/g |
| Molds da Yeasts | <100 cfu/g |
| Tsarkake / Hanyar Bincike | ≥99.0% (HPLC, akan tushen anhydrous) |
| Matsayin Gwaji | Amurka Pharmacopeia (USP) Standard |
| Amfani | Sinadarin Magunguna Mai Aiki (API) |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
lrinotecan hydrochloride (CAS 100286-90-6), wani Semi-synthetic, ruwa mai narkewa wanda ya samo asali na mai ƙarfi anticancer wakili camptothecin, a Japan don maganin ciwon huhu, ovarian, da sankarar mahaifa.lrinotecan yana aiki da aikin antitumor ta hanyar hana topoisomerase I, wani enzyme na salula wanda ke da hannu wajen kiyaye tsarin tsarin DNA yayin aiwatar da fassarar, rubutun, da mitosis.lrinotecan yana jurewa de-esterification a cikin vivo don samar da metabolite mai aiki, SN-38, wanda shine ninki 1000 mafi ƙarfi fiye da iyaye.Haɗuwa da maganin irinotecan tare da wani wakili na maganin ciwon daji da ake amfani da shi sosai, cisplatin, an ruwaito ya fi ko wanne wakili kaɗai.lrinotecan yana cikin gwaje-gwaje na asibiti don gastrointestinal, nono, fata, launin fata, ciwon daji na pancreatic, mesothelioma da lymphoma ba Hodgkin.
