Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Babban Tsabta
Samar da Mai ƙera Irinotecan da Matsakaici masu alaƙa:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Sunan Sinadari | Irinotecan Hydrochloride Trihydrate |
| Makamantu | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Lambar CAS | 136572-09-3 |
| Lambar CAT | RF-API52 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | C33H38N4O6·HCl·3H2O |
| Nauyin Kwayoyin Halitta | 677.20 |
| Matsayin narkewa | 250.0 ~ 256.0 ℃ (Dec.) |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Hasken Rawaya ko Yellow Crystalline Foda |
| Assay (w/w) | 98.0% ~ 102.0% |
| Tsaftace (HPLC) | ≥99.5% |
| Solubility | Dan narkewa a cikin ruwa, ethanol ko chloroform, Ba a iya narkewa a zahiri a cikin acetone |
| Ganewa | ta IR da HPLC, Conforms |
| Takamaiman Juyawar gani | +60°~+73° |
| Ruwa | 7.0% ~ 9.0% |
| Ragowar Magani | Ya bi ka'idodin ICH |
| Ragowa akan Ignition | ≤0.20% |
| Chloride | 5.0% ~ 6.0% |
| pH darajar | 3.0 ~ 5.0 |
| Karfe masu nauyi | ≤20ppm |
| Tsabtace Mutum | ≤0.10% |
| Jimlar ƙazanta | ≤0.50% |
| Yanayin Ajiya | Ajiye a 2-8 ° C, A cikin kwantena da aka rufe kuma ka kare daga haske da danshi |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | Sinadarin Magunguna Mai Aiki (API) |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Shanghai Ruifu Chemical Co., Ltd. shine babban masana'anta kuma mai samar da Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) tare da inganci mai inganci.
Irinotecan Hydrochloride Trihydrate shine topoisomerase I inhibitor wanda akafi amfani dashi don magance ciwon daji na hanji da kansar dubura, yana hana yin amfani da layin DNA ta hanyar ɗaure topoisomerase I-DNA complex.lrinotecan hydrochloride, wani Semi-synthetic, ruwa mai narkewa na mai ƙarfi anticancer wakili camptothecin, an ƙaddamar da shi a Japan don maganin cututtukan huhu, ovarian, da sankarar mahaifa.lrinotecan yana aiki da aikin antitumor ta hanyar hana topoisomerase I, wani enzyme na salula wanda ke da hannu wajen kiyaye tsarin tsarin DNA yayin aiwatar da fassarar, rubutun, da mitosis.lrinotecan yana jurewa de-esterification a cikin vivo don samar da metabolite mai aiki, SN-38, wanda shine ninki 1000 mafi ƙarfi fiye da iyaye.Ko da yake kasancewa ƙasa da mai guba fiye da camptothecin, adadi mai yawa na marasa lafiya a cikin gwaje-gwaje na asibiti sun nuna illa na leukopenia, gudawa, tashin zuciya, da alopecia.Haɗuwa da maganin irinotecan tare da wani wakili na maganin ciwon daji da ake amfani da shi sosai, cisplatin, an ruwaito ya fi ko wanne wakili kaɗai.lrinotecan yana cikin gwaje-gwaje na asibiti don gastrointestinal, nono, fata, launin fata, ciwon daji na pancreatic, mesothelioma da lymphoma ba Hodgkin.
