Lopinavir CAS 192725-17-0 API Mai hana cutar HIV Mai hana COVID-19 Babban Tsabta

Lopinavir (ABT-378) mai ƙarfi ne mai ƙarfi, mai zaɓin peptidomimetic inhibitor na kwayar cutar HIV-1, tare da Kis na 1.3 zuwa 3.6 pM don nau'in daji da ƙwayoyin cuta na mutant HIV.Lopinavir yana aiki ta hanyar kama balaga na HIV-1 don haka yana toshe kamuwa da cuta.Lopinavir kuma shine mai hana SARS-CoV 3CLpro tare da IC50 na 14.2 μM.Lopinavir maganin rigakafi ne na aji mai hana protease.Hana kwayar cutar HIV-1 yana hana ɓarkewar ƙwayar cuta ta polyprotein precursor kuma yana haifar da sakin marasa balagagge, virions marasa kamuwa da cuta.Wani bangare na maganin hadewa don magance cutar kanjamau.Lopinavir, mai hana cutar HIV na shida a cikin aji na "navir", an ƙaddamar da shi a cikin haɗin gwiwa tare da ritonavir, wani mai hana cutar HIV wanda aka riga aka sayar (Abbott, 1996);An gabatar da wannan tsari na asali a matsayin Kaletra don amfani da shi tare da ko dai nucleoside ko wadanda ba na nucleoside masu hana masu hanawa ba don maganin AIDS a cikin manya da yara.Lopinavir wani fili ne na peptidomimetic tare da tushen tsarin daidai da na ritonavir, wanda aka gabatar da ƙungiyoyin tasha, musamman valine da aka gyara, ta hanyoyin haɗin peptide.Lopinavir babban mai hana cutar HIV-I protease ne wanda ke nuna babban yuwuwar rigakafin maye gurbi na ritonavir.A cikin nau'ikan dabbobi da yawa, nazarin pharmacokinetic tare da ƙungiyar lopinavirlritonavir sun nuna cewa ƙayyadaddun kaddarorin lopinavir sun inganta sosai a gaban ritonavir, dangane da Cmax da tsawon lokacin aiki.