Losartan Potassium CAS 124750-99-8 API Factory Antihypertensive High Tsabta
Samar da Potassium Losartan da Matsakaicin Maɗaukaki tare da Ingantacciyar inganci
Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Sunan Sinadari | Potassium Losartan |
| Makamantu | DuP 753;Kozaar;2-Butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl] imidazole-5-methanol Potassium Gishiri. |
| Lambar CAS | 124750-99-8 |
| Lambar CAT | RF-API98 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | Saukewa: C22H22ClKN6O |
| Nauyin Kwayoyin Halitta | 461.01 |
| Matsayin narkewa | 263.0 ~ 265.0 ℃ |
| Solubility | Mai Soluble Kyauta a cikin Ruwa kuma a cikin Methanol, Dan Soluble a cikin Acetonitrile. |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari ko Kusan Farin Crystalline Foda |
| Identification A | Shawar Infrared: Dole ne yayi kama da Ma'auni na Magana |
| Identity B | Shayewar ultraviolet: Dole ne yayi kama da Matsayin Magana |
| Gwajin Potassium | Dole ne ya zama Mai Kyau |
| Abubuwan Ruwa (KF) | ≤0.50% |
| Karfe masu nauyi | ≤10ppm |
| Abubuwa masu alaƙa (HPLC) | |
| Duk wani Rashin Tsabtace Mutum | ≤0.20% |
| Jimlar ƙazanta | ≤0.50% |
| Residual Solvents (GC) | |
| Cyclohexane | ≤0.10% |
| Isopropyl Alcohol | ≤0.20% |
| Hanyar Assay/Analysis | 98.5 ~ 101.0% (HPLC, ƙididdigewa akan anhydrous, ƙarancin ƙarfi) |
| N-Nitrosodiethylamine | ≤0.177pm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Girman Barbashi | 90% Kasa da 38 Microns |
| Rayuwar Rayuwa | Watanni 24 |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | API, Angiotensin II Mai karɓar Mai Rarraba Antihypertensive |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Losartan Potassium shine farkon mai ƙarfi kuma zaɓi wanda ba peptide angiotensin II mai karɓar mai karɓar mai karɓar nau'in 1 (AT1) antagonist wanda aka gabatar wa kasuwa azaman maganin hawan jini na baka sau ɗaya kowace rana.Matsakaicin da ke hana 50% na ɗaurin angiotensin II (IC50) shine 20 nM.Losartan (40 μM) yana shafar ISC amma yana hana tasirin ANGII akan ISC.Losartan yana rage yawan yaduwar kwayar cutar ta Ang II a cikin ƙwayoyin ciwon daji na endometrial.Haɗuwa da losartan da anti-miR-155 yana da tasiri mai mahimmanci na antiproliferative idan aka kwatanta da kowane magani kadai.An daidaita shi don samar da 5-carboxylic acid metabolite (EXP3174) kuma an ba da rahoton rage hawan jini.A halin yanzu ana bincikar shi azaman yuwuwar magani ga COVID-19 don yuwuwar sa don ragewa ko yuwuwar rage alamun COVID-19.
1. Don maganin hauhawar jini mai mahimmanci, ana iya amfani dashi kadai ko a hade tare da wasu magungunan antihypertensive (kamar diuretics).2. Don maganin ciwon zuciya, ana iya amfani dashi kadai ko a hade tare da magungunan cardiotonic ko diuretic Chemicalbook.3. Hana bugun jini a cikin marasa lafiya da hauhawar jini da hauhawar jini na ventricular hagu.4. Ana amfani da shi don rage jinkirin ci gaban nephropathy a cikin marasa lafiya da nau'in ciwon sukari na 2 da ke hade da nephropathy da hauhawar jini.
