Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Tsarkake>99.0% (HPLC) Nintedanib Esylate Intermediate Factory

Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) matsakaici ne da ake amfani dashi don shirya Nintedanib Esylate (CAS: 656247-18-6).Nintedanib Esylate mai ƙarfi ne, mai hanawa na baka sau uku angiokinase wanda Boehringer Ingelheim ya haɓaka wanda ke yin niyya ta hanyoyin proangiogenic da pro-fibrotic waɗanda ke shiga tsakani ta hanyar mai karɓar haɓakar haɓakar jijiyar jijiyoyi, mai karɓar haɓakar haɓakar fibroblast da plateletderived girma factor iyalai, kazalika da Src da Flt-3 kinase.An amince da Nintedanib Esylate don maganin fibrosis na huhu na huhu (IPF), yanayin da huhu ke ci gaba da raguwa a cikin lokaci, ta hanyar FDA ta Amurka a watan Oktoba 2014 da EMA a cikin Janairu 2015. FDA ta ba da nintedanib esylate mai sauri-track. , Bita na fifiko, samfuran marayu, da nadi na ƙima.EMA kuma ta amince da ita a watan Nuwamba 2014 don maganin ciwon huhu mara ƙananan ƙwayoyin cuta a hade tare da docetaxel bayan layin farko na chemotherapy.