Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8 Tsarkake>98.0% (GC) Lenvatinib Mesylate Intermediate Factory

Takaitaccen Bayani:

Sunan Kemikal: Methyl 4-Amino-2-Methoxybenzoate

Saukewa: 27492-84-8

Tsafta:> 98.0% (GC)

Bayyanar: Fari zuwa Kashe-Farin Foda ko Lu'ulu'u

Matsakaicin Lenvatinib Mesylate CAS 857890-39-2

E-Mail: alvin@ruifuchem.com


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Bayani:

Abubuwan Sinadarai:

Sunan Sinadari Methyl 4-Amino-2-Methoxybenzoate
Makamantu 4-Amino-2-Methoxybenzoic Acid Methyl Ester;Methyl 4-Amino-o-Anisate;4-Amino-o-Anisic Acid Methyl Ester
Lambar CAS 27492-84-8
Lambar CAT RF-PI1974
Matsayin Hannun jari A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton
Tsarin kwayoyin halitta Saukewa: C9H11NO3
Nauyin Kwayoyin Halitta 181.19
Yawan yawa 1.179± 0.060 g/cm3
Alamar Ruifu Chemical

Ƙayyadaddun bayanai:

Abu Ƙayyadaddun bayanai
Bayyanar Fari zuwa Kashe-Farin Foda ko Lu'ulu'u
Tsarkake / Hanyar Bincike > 98.0% (GC)
Tsarkake / Hanyar Bincike 97.5 ~ 102.5 (Titration mara kyau)
Matsayin narkewa 157.0 ~ 161.0 ℃
Asara akan bushewa <1.00%
Jimlar ƙazanta <2.0%
Infrared Spectrum Yayi daidai da Tsarin
Abubuwan da aka bayar na Proton NMR Spectrum Yayi daidai da Tsarin
Matsayin Gwaji Matsayin Kasuwanci
Amfani Matsakaicin Lenvatinib Mesylate (CAS: 857890-39-2)

Kunshin & Ajiya:

Kunshin: Bottle, Aluminum tsare jakar, 25kg / kwali Drum, ko bisa ga abokin ciniki ta bukata

Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske da danshi

Amfani:

1

FAQ:

Aikace-aikace:

Methyl 4-Amino-2-Methoxybenzoate (CAS: 27492-84-8) za a iya amfani dashi azaman matsakaici na Lenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib magani ne na ciwon daji na thyroid wanda Eisai Corporation na Japan ya haɓaka (Lambar: E7080), mallakar mai hanawa na tyrosine kinase mai karɓa na baka (RTK) kuma yana iya hana aikin kinase na ƙwararrun ƙwararrun ƙwararrun jijiyoyi (VEGF) masu karɓar VEGFR1 ( FLT1), VEGFR2 (KDR), da VEGFR3 (FLT4).Lenvatinib kuma zai iya hana shigar da sauran RTKs a cikin angiogenesis na pathological, ci gaban tumo, da ci gaban ciwon daji sai dai don ayyukan salula na yau da kullum ciki har da masu karɓar fibroblast girma factor (FGF) FGFR1, 2, 3, da 4;Mai karɓar haɓakar haɓakar platelet (PDGFR [alpha]), KIT, da RET.[Alamomi]: Lenvatinib ya dace da maganin marasa lafiya na ciwon daji na thyroid na sake dawowa gida ko nau'in metastasis, nau'in ci gaba da nau'in rediyoaktif-refractory daban-daban.Ranar 13 ga Fabrairu, 2015, FDA ta Amurka ta amince da Lenvatinib na maganin ciwon daji don maganin ciwon daji na thyroid.Lenvatinib shine mai hanawa enzyme mai yawan manufa, yana da ikon hana VEGFR2 da VEGFR3 (mai karɓar haɓakar haɓakar haɓakar ƙwayoyin jijiyoyi).Sunan kasuwancin Lenvatinib shine Lenvima.A ranar 20 ga Mayu, 2015, Hukumar Kula da Magunguna ta Turai (EMA) ta amince da Lenvatinib don maganin cutar daji, ci gaba a cikin gida ko metastatic bambanta (papillary, follicular, nau'in Hurthle) ciwon daji na thyroid (DTC).A cikin gwajin, lokacin rayuwa na tsaka-tsaki ga marasa lafiya na rediyoaktif iodine-refractory DTC da aka yi wa Lenvatinib ya kasance watanni 18 yayin da ƙimar marasa lafiya da ke ɗaukar placebo shine watanni 3 kawai.

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