Molnupiravir (EIDD-2801) CAS 2349386-89-4 COVID-19 API Babban inganci
Samar da Kasuwancin Molnupiravir da Matsakaici masu alaƙa tare da Ingantacciyar inganci
Uridine CAS 58-96-8
Cytidine CAS 65-46-3
Molnupiravir N-1 CAS 2346620-55-9
Molnupiravir (EIDD-2801) CAS 2349386-89-4
| Sunan Sinadari | Molnupiravir (EIDD-2801) |
| Makamantu | MK-4482;β-D-N4-Hydroxycytidine-5'-isopropyl ester;((2R,3S,4R,5R) -3,4-dihydroxy-5-((E) -4- (hydroxyimino) -2-oxo-3,4-dihydropyrimidin-1 (2H) -yl) tetrahydrofuran-2 -yl) methyl isobutyrate |
| Lambar CAS | 2349386-89-4 |
| Lambar CAT | RF-API97 |
| Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
| Tsarin kwayoyin halitta | Saukewa: C13H19N3O7 |
| Nauyin Kwayoyin Halitta | 329.31 |
| Solubility | Mai narkewa a cikin DMSO |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari zuwa Kashe-Farin Foda |
| Gano IR | Samfurin Spectrum yayi daidai da ma'aunin tunani |
| Bayanin HPLC | Lokacin riƙewa na babban kololuwar samfurin samfurin ya dace da na daidaitaccen bayani |
| Abubuwa masu alaƙa | |
| Najasa A | ≤0.15% |
| Rashin tsarki B | ≤0.15% |
| Duk Wani Tsaftar Da Ba A Fayyace Ba | ≤0.15% |
| Jimlar ƙazantattun da ba a fayyace su ba | ≤0.30% |
| Jimlar ƙazanta | ≤0.50% |
| Ragowar Magani | |
| N-Heptane | ≤5000ppm |
| Ethanol | ≤5000ppm |
| Isopropyl acetate | ≤5000ppm |
| Acetonitrile | ≤410pm |
| Methylene Dichloride | ≤600ppm |
| Acetone | ≤5000ppm |
| isopropanol | ≤5000ppm |
| Abubuwan Ruwa (KF) | ≤0.50% |
| Ragowa akan Ignition | ≤0.10% |
| Juyawar gani | -7.5° zuwa -9.5° (C=0.5, methanol) |
| Karfe masu nauyi | ≤10ppm |
| Tsarkake / Hanyar Bincike | ≥99.5% (230nm) |
| Hanyar Assay / Analysis | 98.0% ~ 102.0% (HPLC akan busasshiyar tushe) |
| Rayuwar Rayuwa | Watanni 24 |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | API, Molnupiravir (EIDD-2801) Mai hana COVID-19 |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Molnupiravir (EIDD-2801, MK-4482) wani prodrug ne na baki bioavailable prodrug na ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) tare da m-bakan antiviral aiki a kan SARS-CoV-2, MERS-CoV, SARS-CoV, kuma wakili mai haifar da COVID-19.Ana sayar da Molnupiravir a ƙarƙashin sunan alamar Lagevrio kuma gabaɗaya a matsayin emorivir.An nuna Molnupiravir don inganta aikin huhu, rage nauyin jiki da rage yawan ƙwayar cuta a cikin huhu.Baya ga aiki da coronaviruses, Molnupiravir, a cikin binciken dakin gwaje-gwaje, ya nuna aiki akan kamuwa da cuta na yanayi da na tsuntsaye, kwayar cutar syncytial na numfashi, cutar chikungunya, cutar Ebola, kwayar cutar encephalitis equine Venezuelan, da kwayar cutar encephalitis ta Gabas.Molnupiravir an samo asali ne don maganin mura a Jami'ar Emory ta kamfanin samar da magungunan jami'ar, Drug Innovation Ventures at Emory (DRIVE), amma an yi watsi da shi saboda matsalolin mutagenicity.Daga nan ne kamfanin Ridgeback Biotherapeutics na Miami ya samo shi, wanda daga baya ya yi haɗin gwiwa tare da Merck & Co. don haɓaka maganin gabaɗaya.An amince da Molnupiravir don amfani da magani a cikin Burtaniya a cikin Nuwamba 2021.
