N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC High Quality
Ƙarfafawa tare da Babban Tsafta da Ƙarfin Ƙarfi
Sunan Chemical: N (4) -Hydroxycytidine;EIDD-1931 (NHC)
Saukewa: 3258-02-4
Metabolite mai aiki na Molnupiravir, mai hana COVID-19 mai alƙawarin
| Sunan Sinadari | N (4)-Hydroxycytidine |
| Makamantu | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Lambar CAS | 3258-02-4 |
| Lambar CAT | Saukewa: RF-PI309 |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin Samarwa Har zuwa Kilogram |
| Tsarin kwayoyin halitta | Saukewa: C9H13N3O6 |
| Nauyin Kwayoyin Halitta | 259.22 |
| Matsayin narkewa | 169.0 ~ 172.0 ℃ |
| Solubility | Mai narkewa zuwa 100 mM a cikin DMSO kuma zuwa 50 mM a cikin Ruwa |
| Yawan yawa | 1.93± 0.1 g/cm3 |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari zuwa Kashe-Farin Foda |
| NMR | Daidai da Tsarin |
| Tsarkake / Hanyar Bincike | 98% (HPLC) |
| Asara akan bushewa | ≤1.0% |
| Tsaftace Guda Daya | ≤0.50% |
| Karfe masu nauyi | ≤20ppm |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | Metabolite mai aiki na Molnupiravir (EIDD-2801), mai hana COVID-19 |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
N (4) -Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) wani aiki ne na EIDD-2801, mai hana COVID-19 mai ban sha'awa.EIDD-1931 (NHC) yana da faffadan ayyukan rigakafin kamuwa da cutar coronavirus da yawa, gami da SARS-CoV-2, MERS-CoV, SARS-CoV, da rukunin zoonotic 2b ko 2c Bat-CoVs tare da matsakaita IC50 na 0.15 μM, haka kuma Ƙarfafa ƙarfi a kan ƙwayar cuta mai ɗauke da ƙwayar cuta ta coronavirus zuwa mai hanawar analog na nucleoside remdesivir.A cikin berayen da suka kamu da SARS-CoV ko MERS-CoV, duka prophylactic da kula da warkewa na Molnupiravir (EIDD-2801), samfurin NHC-prodrug na baka (β-D-N4-hydroxycytidine-5'-isopropyl ester), ingantaccen aikin huhu. , da kuma rage adadin ƙwayoyin cuta da asarar nauyin jiki.Rage yawan amfanin MERS-CoV a cikin vitro da in vivo suna da alaƙa da haɓaka mitar maye gurbi a cikin hoto ko bidiyo mai zagaya yanar gizo da sauri amma ba mai karɓar RNA ba, yana goyan bayan tsarin mutagenesis na mutuwa a cikin CoV.Ƙarfin NHC/EIDD-2801 a kan coronaviruses da yawa da kuma bioavailability na baka yana nuna yuwuwar amfanin sa azaman ingantacciyar rigakafin cutar SARS-CoV-2 da sauran coronaviruses zoonotic na gaba.
