Naproxen CAS 22204-53-1 Tsafta > 99.5% (HPLC)

Naproxen (CAS: 22204-53-1) magani ne wanda ba na steroidal anti-mai kumburi ba, yana da PG synthase inhibitor, wanda zai iya hana prostaglandin synthetase, yana da tasirin analgesic da antipyretic mai mahimmanci, shayar baki yana da sauri kuma cikakke, 2 zuwa Sa'o'i 4 bayan kashi, ƙwayar plasma ya kai kololuwa, a cikin jini, fiye da 99% an ɗaure su da sunadaran plasma, t1/2 shine awanni 13 zuwa 14, kusan 95% ana fitar da shi daga fitsari tare da samfuri da metabolites.Ana amfani da shi a asibiti don maganin rheumatic da rheumatoid amosanin gabbai, osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis. Hakanan ana iya amfani dashi don rage radadin da ke haifar da musculoskeletal sprains, contusions, lalacewa da dysmenorrhea.Amma ya kamata a lura da cewa kamar sauran wadanda ba steroidal anti-kumburi kwayoyi, guda tsanani gastrointestinal m halayen na iya faruwa a kowane lokaci yayin shan naproxen a lokacin jiyya, don haka masu aiki gastroduodenal ulcer marasa lafiya suna rataye, sauran gastrointestinal fili cututtuka ya kamata su dauki wannan. miyagun ƙwayoyi ƙarƙashin kulawar likita.Naproxen an haɗa shi daga 2-methoxynaphthalene da (+) -isomer da aka samu ta hanyar ƙuduri tare da cinchonidine (61).An gabatar da shi a cikin Amurka a cikin 1976 kuma, azaman magani na gabaɗaya, ya kasance koyaushe yana cikin shahararrun NSAIDs.Ana sayar da shi azaman S- (+) -enantiomer, amma abin sha'awa, gishiri sodium na (-) isomer shima yana kan kasuwa kamar Anaprox.A matsayin mai hana prostaglandin biosynthesis, yana da ƙarfi sau 12 fiye da aspirin, sau 10 mafi ƙarfi fiye da phenylbutazone, sau uku zuwa huɗu mafi ƙarfi fiye da ibuprofen, kuma sau huɗu mafi ƙarfi fiye da fenoprofen, amma kusan sau 300 ƙasa da ƙarfi. indomethacin.