Ondansetron Hydrochloride Dihydrate CAS 103639-04-9 Assay 98.0 ~ 102.0%

Takaitaccen Bayani:

Sunan Sinadari: Ondansetron Hydrochloride Dihydrate

Saukewa: 103639-04-9

Assay: 98.0 ~ 102.0% (Lissafta akan tushen anhydrous)

Bayyanar: Fari ko Kashe-White Crystalline Foda

A Musamman Serotonin (5-HT3).Antiemetic

Tuntuɓi: Dr. Alvin Huang

Wayar hannu/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Bayani:

Shanghai Ruifu Chemical shine babban masana'anta na Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) tare da babban inganci.Ruifu na iya samar da isar da sako na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da yawa da ake samu.Sayi Ondansetron Hydrochloride Dihydrate,Please contact: alvin@ruifuchem.com

Matsakaici masu alaƙa:

Abubuwan Sinadarai:

Sunan Sinadari Ondansetron Hydrochloride Dihydrate
Makamantu Ondansetron HCl Dihydrate;1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-imidazol-1-yl) methyl] -4H-Carbazol-4-daya Hydrochloride Dihydrate;Emeset;GR 38032 Hydrochloride Dihydrate;SN 307 Hydrochloride Dihydrate;GR 3832 HCl 2H2O;SN-37 HCl 2H2O;Saukewa: NSC665799HCl 2H2O
Matsayin Hannun jari A Stock, Sikelin Kasuwanci
Lambar CAS 103639-04-9 (Dihydrate)
Abubuwan da suka dace da CAS RN 99614-02-5 (Base) & 99614-01-4 (Anhydrous)
Tsarin kwayoyin halitta C18H19N3O·HCl·2H2O
Nauyin Kwayoyin Halitta 365.86 g/mol
Matsayin narkewa 176.0 zuwa 180.0 ℃
M Zafi Sensitive
Ruwan Solubility Mai narkewa a cikin Ruwa (> 5 mg/ml)
Adana Yanayin. Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃)
COA & MSDS Akwai
Alamar Ruifu Chemical

Ƙayyadaddun bayanai:

Abubuwa Ka'idojin dubawa Sakamako
Bayyanar Fari zuwa Kashe-White Crystalline Foda Ya bi
Ganewa    
1. UV Max 209, 248, 267, 310nm Cancanta
2. Bakan IR Yayi daidai da Tsarin Cancanta
3. Wariya na Chloride Ra'ayin Gaba Cancanta
Ruwa ta Karl Fischer 9.0 ~ 10.5% 9.7%
Ragowa akan Ignition ≤0.10% 0.03%
Karfe masu nauyi (Pb) ≤10ppm <10ppm
Abubuwan da suka danganci Ondansetron C ≤0.20% 0.09%
Abubuwan da ke da alaƙa da Ondansetron D ≤0.10% 0.04%
Imidazole ≤0.20% 0.02%
2-Methylimidazole ≤0.20% 0.02%
Abubuwan da ke da alaƙa da Ondansetron A ≤0.20% 0.05%
Sauran Rashin Tsabtace Guda Daya da Ba'a Sani ba ≤0.10% 0.07%
Jimlar ƙazanta ≤0.50% 0.29%
Residual Solvent    
Ethanol ≤5000ppm 240ppm ku
Assay 98.0 ~ 102.0% (Lissafta akan tushen anhydrous) 99.81%
Kammalawa An gwada samfurin kuma ya dace da ƙayyadaddun bayanai

Kunshin/Ajiye/Jirgin ruwa:

Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin akwati da aka rufe sosai.Ajiye a cikin sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.

Amfani:

Isasshen Ƙarfin: isassun wurare da masu fasaha

Sabis na Ƙwararru: Sabis na siyan tasha ɗaya

Kunshin OEM: Kunshin al'ada da alamar akwai

Bayarwa da sauri: Idan yana cikin haja, garantin isar da kwanaki uku

Ƙarfin Ƙarfi: Kula da haja mai ma'ana

Taimakon Fasaha: Akwai maganin fasaha

Sabis na Haɗa na Musamman: Ya bambanta daga gram zuwa kilos

High Quality: An kafa cikakken tsarin tabbatar da inganci

FAQ:

Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Kwarewar Shekaru 15?Muna da fiye da shekaru 15 na gwaninta a cikin ƙira da fitarwa na matsakaicin matsakaicin magunguna masu inganci ko sinadarai masu kyau.

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Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.

inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.

Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.

Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.

MOQ?Babu MOQ.Karamin tsari abin karɓa ne.

Lokacin Bayarwa? Idan cikin hannun jari, garantin isar da kwana uku.

Sufuri?By Express (FedEx, DHL), ta Air, ta Teku.

Takardu?Bayan sabis na tallace-tallace: COA, MOA, ROS, MSDS, da dai sauransu za a iya ba da su.

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103639-04-9 - Haɗari da Tsaro:

Lambobin haɗari
R25 - Mai guba idan an haɗiye shi
R36/37/38 - Haushi da idanu, tsarin numfashi da fata.
Bayanin Tsaro
S45 - Idan akwai haɗari ko kuma idan kun ji rashin lafiya, nemi shawarar likita nan da nan (nuna alamar a duk lokacin da zai yiwu.)
S37/39 - Saka safofin hannu masu dacewa da kariya / ido
S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita.
ID na UN 2811 6.1/PG 3
WGK Jamus 3
Saukewa: RTECS FE6375500
Farashin 29339900
Matsayin Hazard 6.1(a)
Rukunin tattarawa II

103639-04-9 - Aikace-aikace:

Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) ƙayyadaddun antagonist mai karɓar serotonin (5-HT3).Antiemetic.Ana amfani da Ondansetron Hydrochloride Dihydrate don hana tashin zuciya da amai wanda zai iya faruwa ta hanyar tiyata, chemotherapy, ko maganin radiation.5-HT3 antagonists receptor antagonists a cikin Ondansetron sune magungunan farko da ake amfani da su don magancewa da kuma hana cutar chemotherapy-jawo tashin zuciya da amai da tashin zuciya da amai da radiotherapy, ta hanyar toshe ayyukan sinadarai a cikin jiki.Amfanin yana da kyau fiye da metoclopramide yayin da ƙasa da kwanciyar hankali fiye da cyclizine ko droperidol.Duk da haka, yana da ɗan tasiri akan amai da ciwon motsi ya haifar.Ana iya ba da shi ta baki, ta hanyar allura a cikin tsoka ko cikin jijiya.

Ondansetron da Granisetron, Dolasetron sune magungunan antiemetics na asibiti guda uku da aka saba amfani da su, ondansetron shine mai hana mai karɓar mai karɓa na serotonin (5-HT3) wanda ke juyawa da zaɓi, don α1, α2, β1, β2-adrenergic masu karɓa da histamine H1, H2 masu karɓa, shi. yana da ƙaramin sakamako, don masu karɓar H, masu karɓa na tsakiya da na gefe dopaminergic, ba shi da wani sakamako mai ƙin yarda, yana iya kashe maganin cutar sankara da tashin zuciya da amai.Idan aka kwatanta da metoclopramide, tasirin sa na antiemetic ya fi ƙarfi kuma ba shi da halayen extrapyramidal.Don amai da cisplatin ya haifar, cyclophosphamide, doxorubicin, da dai sauransu zai iya haifar da sakamako mai sauri da ƙarfi.Ya dace ba kawai don maganin tashin zuciya da amai da ke haifar da chemotherapy na cytotoxic da radiation farfesa ba, har ma don rigakafi da maganin tashin zuciya da amai da tiyata ke jawo.Ondansetron yana aiki azaman hanyar wucewa tsakanin jijiyar visceral afferent da aka kunna a cikin gastrointestinal tract da cibiyar amai a cikin kashin baya, wanda ke haifar da diaphragm da motsin tsokoki na ciki.Chemotherapy da radiation far iya haifar da hanji 5-HT saki da kuma haifar da vagus jijiya ruri ta 5-HT3 mai karɓa, wanda ya sa amai reflex.Wannan samfurin yana toshe wannan reflex da ke faruwa, a lokaci guda yana toshe amai da ke haifar da aikin tsakiya.Hanyar game da tashin zuciya da amai ba a sani ba.Ondansetron a hade tare da dexamethasonecan na iya haɓaka tasirin anti-emetic.

103639-04-9 - Tasirin Gaba:

Wannan yana haifar da fitowar afferent na vagal, yana haifar da amai.A cikin ɗaure ga masu karɓa na 5-HT3, ondansetron yana toshe haɓakawar serotonin, saboda haka amai, bayan abubuwan haɓakawa na emetogenic kamar cisplatin.Ciwon kai shine mafi yawan lokuta da aka ruwaito mummunan sakamako na waɗannan magunguna.

103639-04-9 - Bayanan Tsaro:

Guba ta hanyar jijiya. Tasirin tsarin ɗan adam ta hanyar jijiya: jaundice.Lokacin zafi don bazuwa yana fitar da tururi mai guba na NOx.

103639-04-9 - Magungunan Dabbobi da Magunguna:

An yi amfani da shi azaman maganin hana kumburi lokacin da magungunan antiemetic na al'ada ba su da tasiri, kamar lokacin gudanar da cisplatin ko don wasu abubuwan da ke haifar da amai mara nauyi.Yin amfani da ondansetron a cikin kuliyoyi yana da ɗan rikici kuma wasu jihohi bai kamata a yi amfani da shi a cikin wannan nau'in ba.

Mu'amalar ƙwayoyi Mai yuwuwar mu'amala mai haɗari tare da wasu magunguna.

103639-04-9 - USP35 Standard:

Ondansetron Hydrochloride ya ƙunshi ba kasa da 98.0 bisa dari kuma bai wuce 102.0 bisa dari na C18H19N3O·HCl, lissafta a kan anhydrous tushen.
Marufi da ajiya-Ajiye a cikin matsatsi, kwantena masu jure haske.Store a 25, an ba da izinin balaguro tsakanin 15kuma 30.
Matsayin Magana na USP <11>-
USP Ondansetron Hydrochloride RS
USP Ondansetron Abubuwan da ke da alaƙa A RS
3[(Dimethylamino)methyl] -1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-daya.
USP Ondansetron Resolution Mixture RS
Ondansetron hydrochloride yana da kusan 0.4% w/w na abubuwan da suka shafi ondansetron A da 6,6¢-methylene bis-[(1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-)] imidazol-1-yl)-methyl]-4H-carbazol-4-daya)]
USP Ondansetron Abubuwan da ke da alaƙa C RS
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-daya.
USP Ondansetron Maɗaukakin Haɗaɗɗiyar D RS
1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-daya.
Ganewa-
A: Ciwon Infrared <197M>.
B: Narke 20 MG a cikin 2 ml na ruwa, ƙara 1 ml na 2 M nitric acid, kuma tace: tacewa yana amsa gwajin Chloride <191>.
Ruwa, Hanyar Ia <921>: tsakanin 9.0% da 10.5%.
Ragowa akan kunnawa <281>: bai wuce 0.1% ba.
Iyakar abubuwan da ke da alaƙa da ondansetron D-
Wayar hannu lokaci- Shirya cakuda mai tacewa da gurɓataccen 0.02 M monobasic potassium phosphate (wanda aka riga an daidaita shi tare da 1 M sodium hydroxide zuwa pH na 5.4) da acetonitrile (80:20).Yi gyare-gyare idan ya cancanta (duba Dacewar Tsarin ƙarƙashin Chromatography <621>).
Daidaitaccen bayani-Narkar da daidaitaccen adadin USP Ondansetron Related Compound D RS a cikin Wayar hannu lokaci, kuma a tsarma ƙididdigewa, da mataki-mataki idan ya cancanta, tare da lokacin Wayar hannu don samun mafita da samun sanannen taro na kusan 0.4 µg kowace ml.
Maganin dacewa da tsarin-Narkar da adadin da suka dace na USP Ondansetron Related Compound D RS da USP Ondansetron Related Compound C RS a cikin Wayar hannu, kuma a tsarke ƙididdigewa, da mataki-mataki idan ya cancanta, tare da lokacin Wayar hannu don samun mafita yana da kusan 0.6 µg kowace ml. da kuma 1 μg kowace ml, bi da bi.
Maganin Gwajin-Canja wurin kusan 50 MG na Ondansetron Hydrochloride, daidai aunawa, zuwa filasta mai girma na 100-mL, narkar da kuma tsarma tare da lokacin Wayar hannu zuwa girma, da haɗuwa.
Tsarin Chromatographic (duba Chromatography <621>) -Chromatograph na ruwa yana sanye da na'urar ganowa 328-nm da ginshiƙi na 4.6-mm × 25-cm wanda ya ƙunshi tattara L10.Matsakaicin kwarara shine kusan 1.5 ml a minti daya.Chromatograph da tsarin dacewa da tsarin, da yin rikodin martanin kololuwa kamar yadda aka umurce su don Tsari: lokutan riƙewa na dangi kusan 0.8 ne don abun da ke da alaƙa da ondansetron C da 1.0 don abubuwan da ke da alaƙa da ondansetron D;da ƙuduri, R, tsakanin ondansetron alaka fili C da ondansetron alaka fili D bai kasa da 1.5.Chromatograph the Standard bayani, da kuma rikodin mafi girman martani kamar yadda aka ba da umarni don Tsari: ingancin ginshiƙi da aka ƙaddara daga kololuwar nazari bai gaza faranti 400 na ka'idar ba;kuma madaidaicin ma'auni na dangi don kwafin injections bai wuce 2.0%.
Tsari- Na dabam allura daidai juzu'i (kimanin 20 µL) na daidaitaccen bayani da maganin Gwaji a cikin chromatograph, yi rikodin chromatograms, da auna martani ga manyan kololuwa.Yi ƙididdige adadin abubuwan da ke da alaƙa da ondansetron D a cikin ɓangaren Ondansetron Hydrochloride wanda aka ɗauka ta dabara:
10,000 (C/W)(rU/rS)
a cikin abin da C shine maida hankali, a cikin MG kowace ml, na USP Ondansetron Related Compound D RS a cikin Ma'auni na daidaitaccen bayani;W shine nauyin, a cikin MG, na Ondansetron Hydrochloride da aka ɗauka don shirya maganin gwajin;da rU da rS sune wuraren kololuwar da aka samu daga maganin Gwajin da Ma'auni na Ma'auni, bi da bi: ba a sami fiye da 0.10% ba.
Tsaftar Chromatographic-
hanyar i-
Maganin ƙuduri-Narkar da adadin USP Ondansetron Resolution Mixture RS a cikin methanol, kuma a tsarma ƙima, da mataki-mataki idan ya cancanta, tare da methanol don samun maganin da yake da sananniya na 12.5 MG kowace ml.
Daidaitaccen mafita-Narkar da adadin USP Ondansetron Hydrochloride RS daidai gwargwado a cikin methanol, da gauraya don samun mafita mai sananniya na kusan 0.25 MG kowace ml.Tsarkake wannan bayani da yawa tare da methanol don samun daidaitattun mafita, wanda aka tsara a ƙasa ta wasiƙa, yana da abubuwan da ke biyowa:

Daidaitaccen bayani Dilution Hankali (µg RS a kowace ml) Kashi (%, don kwatanta da samfurin gwaji)
A (1 cikin 5) 50 0.4
B (1 cikin 10) 25 0.2
C (1 cikin 20) 12.5 0.1

Maganin Gwaji-Narke daidaitaccen adadin Ondansetron Hydrochloride a cikin methanol don samun mafita mai ɗauke da 12.5 MG kowace ml.Tsari- dabam a yi amfani da 20 µL na maganin gwajin, 20 µL na kowane daidaitaccen bayani, da 20 µL na maganin Ƙaddamarwa zuwa farantin chromatographic na bakin ciki (duba Chromatography).621) mai rufi da 0.25-mm Layer na chromatographic silica gel cakuda.Ƙirƙirar chromatogram a cikin tsarin narkewa wanda ya ƙunshi cakuda chloroform, ethyl acetate, methanol, da ammonium hydroxide (90:50:40:1) har sai da gaban sauran ƙarfi ya motsa kusan kashi uku cikin huɗu na tsawon farantin.Cire farantin daga ɗakin, yi alama a gaban sauran ƙarfi, kuma ba da damar sauran ƙarfi ya ƙafe.Bincika farantin a ƙarƙashin hasken UV mai ɗan gajeren zango: an sami cikakken ƙuduri na sassa uku na wurin warware matsalar.Kwatanta ƙarfin kowane tabo na biyu da aka gani a cikin chromatogram na maganin gwajin tare da na manyan tabo a cikin chromatograms na daidaitattun mafita: kowane tabo na biyu daga chromatogram na maganin gwajin yana da ƙimar RF daidai da na babba mafi girma. tabo na Maganin Ƙaddamarwa bai fi girma ko mafi tsanani fiye da ainihin tabo da aka samu daga Standard bayani A (0.4%);kuma babu wani wuri na biyu daga chromatogram na maganin gwajin da ya fi girma ko mafi tsanani fiye da babban tabo da aka samu daga Standard solution B (0.2%).

hanyar ii-

Tsarin wayar hannu da tsarin Chromatographic-Ci gaba kamar yadda aka umarce shi a cikin Assay.
Daidaitaccen bayani-ci gaba kamar yadda aka umarce shi don Daidaitaccen shiri a cikin Assay.
Maganin gwaji-Yi amfani da shirye-shiryen Assay.
Tsari-Na dabam allura daidai juzu'i (kimanin 10 µL) na daidaitaccen bayani da maganin Gwaji a cikin chromatograph, yin rikodin chromatograms, da auna mafi girman martani.Yi ƙididdige adadin kowane ƙazanta a cikin ɓangaren Ondansetron Hydrochloride da aka ɗauka ta dabara:
50,000 (C/W)(1/F)(ri / rS)
a cikin abin da C shine maida hankali, a cikin MG kowace ml, na USP Ondansetron Hydrochloride RS a cikin daidaitaccen bayani;W shine nauyin, a cikin MG, na Ondansetron Hydrochloride da aka ɗauka don shirya maganin gwajin;F shine yanayin mayar da martani na dangi na ƙazanta kamar yadda aka bayyana a cikin tebur mai biye;ri shine yanki kololuwa ga kowane kazanta a cikin maganin gwajin;kuma rS shine yanki mafi girma na ondansetron da aka samu daga Ma'auni na Ma'auni: ya dace da buƙatun da aka bayar a cikin tebur mai biye.

Sunan Haɗin Kai Lokacin Tsayawa Dangi Dan uwa
Martani
Factor
Iyaka (%)
Abubuwan da ke da alaƙa da Ondansetron C kusan 0.32 1.2 0.2
Abubuwan da ke da alaƙa da Ondansetron D* ku 0.34 - 0.1
Imidazole ku 0.49 0.3 0.2
2-methylimidazole ku 0.54 0.4 0.2
Ondansetron 1.0 - -
Abubuwan da ke da alaƙa da Ondansetron A kusan 1.10 0.8 0.2
Ba a sani ba - 1.0 0.1
Jimlar - - 0.5
* Ƙididdigewa a cikin gwaji don Iyakar abubuwan da ke da alaƙa da ondansetron D.
Assay-

Lokacin wayar hannu-Shirya cakudaccen tacewa da gurɓataccen 0.02 M monobasic sodium phosphate (wanda aka riga aka daidaita tare da 1 M sodium hydroxide zuwa pH na 5.4) da acetonitrile (50:50).Yi gyare-gyare idan ya cancanta (duba Dacewar Tsarin ƙarƙashin Chromatography <621>).
Daidaitaccen shiri-Narkar da daidaitaccen adadin USP Ondansetron Hydrochloride RS a cikin Wayar hannu, kuma a tsarke ƙima, da kuma mataki-mataki idan ya cancanta, tare da lokacin Wayar hannu don samun mafita yana da sanannen taro kusan 90 µg kowace ml.
Maganin dacewa da tsarin-Narkar da adadin da suka dace na USP Ondansetron Hydrochloride RS da USP Ondansetron Related Compound A RS a cikin Wayar hannu, kuma a tsarke ƙima, da mataki-mataki idan ya cancanta, tare da lokacin Wayar hannu don samun mafita mai ɗauke da kusan 90 µg kowace ml da 20 µg kowace ml. , bi da bi.
Shirye-shiryen Assay-Canja wurin kusan 45 MG na Ondansetron Hydrochloride, daidaitaccen auna, zuwa filasta mai girma na 50-mL, narkar da kuma tsarma tare da lokacin Wayar hannu zuwa girma, da haɗuwa.Pipet 5.0 ml na wannan maganin a cikin faifan volumetric 50-ml, tsarma tare da Wayar hannu zuwa girma, da haɗuwa.
Tsarin Chromatographic (duba Chromatography <621>) -Chromatograph na ruwa yana sanye da na'urar ganowa 216-nm da ginshiƙi na 4.6-mm × 25-cm wanda ya ƙunshi tattara L10.Matsakaicin kwarara shine kusan 1.5 ml a minti daya.Chromatograph da tsarin dacewa da tsarin, da yin rikodin martanin kololuwa kamar yadda aka ba da umarni don Tsari: lokutan riƙewa dangi kusan 1.0 don ondansetron da 1.1 don abubuwan da ke da alaƙa da ondansetron A;da ƙuduri, R, tsakanin ondansetron alaka fili A da ondansetron bai kasa da 1.5.Chromatograph da Daidaitaccen shiri, da rikodin mafi girman martani kamar yadda aka ba da umarni don Tsari: ma'aunin wutsiya bai wuce 2.0 ba;kuma madaidaicin ma'auni na dangi don kwafin injections bai wuce 1.5%.
Tsari-Na dabam allura daidai juzu'i (kimanin 10 µL) na daidaitaccen shiri da shirye-shiryen Assay a cikin chromatograph, yi rikodin chromatograms, da auna martani ga manyan kololuwa.Yi ƙididdige adadin, a cikin MG, na C18H19N3O·HCl a cikin ɓangaren Ondansetron Hydrochloride da aka ɗauka ta dabara:
500C (rU / rS)
wanda C shine maida hankali, a cikin MG da ml, na USP Ondansetron Hydrochloride RS a cikin Shirye-shiryen Standard;da rU da rS sune wuraren kololuwar da aka samu daga shirye-shiryen Assay da Daidaitaccen shiri, bi da bi.

103639-04-9 - Hanyar samarwa:

Hanyar 1: Bayan amsawar 2-Bromoaniline da1,3-Cyclohexanedione, An samo asali na tetrahydrocarbazole, kuma ana samun fili (III) ta hanyar amsawa tare da dimethylamine da diformaldehyde, da kuma gabatar da dimethylaminomethyl a matsayi na 2.3.80G na fili (III) an amsa tare da methyl iodide don ba da 5.72g na fili (IV) ta hanyar quaternizing sashin amino rukuni na gefe yayin gabatar da ƙungiyar methyl a matsayi 9. 2.0g na fili (IV) da 2-methyl-1h -imidazole an amsa a cikin dimethylformamide tare da motsawa a 95 ℃.Don samun 0.60G na Ondansetron.

Hanyar 2: Halin cyclohexanone da phenylhydrazine sun ba da tetrahydrocarbazole a cikin 85% yawan amfanin ƙasa.Narke shi a cikin tetrahydrofuran da ruwa, ƙara 2,3 Dropwise a 0 °c a cikin nitrogen, Maganin 5, 6-tetrachloro-1,4-benzoquinone a cikin tetrahydrofuran an motsa shi don ba da samfurin oxidation (II) a cikin 67.4% yawan amfanin ƙasa.Compound (II), ethanol, maida hankali hydrochloric acid, paraformaldehyde da dimethylamine hydrochloride aka refluxed tare.Bayan jiyya, samfurin (V) an samo shi ta ƙara mai da hankali hydrochloric acid zuwa acetone da motsawa a 50 ℃.A cikin 71.7% yawan amfanin ƙasa.An mayar da martani (V) da 2-methylimidazole a cikin ruwa a 110 ℃.Don samun fili (VI) a cikin 70.9% yawan amfanin ƙasa.An zuga mahadi (VI), methyl iodide da potassium carbonate a dakin da zafin jiki har sai dattin ya ɓace.An zuba shi a cikin ruwa, an motsa shi, an tace, an wanke shi da ruwa, kuma an sake yin amfani da shi daga methanol don samun ondansetron a cikin kashi 57.2% na yawan amfanin ƙasa.Narkar da shi a cikin cakuda acetone da ruwa, Ta ƙara maida hankali hydrochloric acid zuwa dauki, ondansetron hydrochloride dihydrate an samu tare da yawan amfanin ƙasa na 92.6%.

Hanyar 3: fili (II), potassium carbonate, acetone da dimethyl sulfate an motsa su a dakin da zafin jiki.An samu mahadi (VII) a cikin yawan amfanin ƙasa na 91%.An narkar da mahadi (VII) a cikin ethanol kuma an ƙara cakuda paraformaldehyde na ɗan adam da dimethylamine hydrochloride a cikin sassan ƙarƙashin reflux.Refluxing.Bayan jiyya, an samo fili (VIII) a cikin 67% yawan amfanin ƙasa.(Viii) narkar da a cikin anhydrous ethanol, hydrogen chloride gas, hydrochloride.An ƙara hydrochloride a cikin ruwa kuma an ƙara 2 a 50 ℃.Methylimidazole, refluxing ondansetron, samar da 70%.An narkar da shi a cikin isopropanol, ruwa da hydrochloric acid mai mahimmanci, kuma an zuga shi a dakin da zafin jiki don samun ondansetron hydrochloride dihydrate a cikin yawan amfanin ƙasa na 90.5%.

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