Ondansetron Hydrochloride Dihydrate CAS 103639-04-9 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical shine babban masana'anta na Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) tare da babban inganci.Ruifu na iya samar da isar da sako na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da yawa da ake samu.Sayi Ondansetron Hydrochloride Dihydrate,Please contact: alvin@ruifuchem.com
Matsakaici masu alaƙa na Ondansetron Hydrochloride Dihydrate
Sunan Sinadari | Ondansetron Hydrochloride Dihydrate |
Makamantu | Ondansetron HCl Dihydrate;1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-imidazol-1-yl) methyl] -4H-Carbazol-4-daya Hydrochloride Dihydrate;Emeset;GR 38032 Hydrochloride Dihydrate;SN 307 Hydrochloride Dihydrate;GR 3832 HCl 2H2O;SN-37 HCl 2H2O;Saukewa: NSC665799HCl 2H2O |
Matsayin Hannun jari | A Stock, Sikelin Kasuwanci |
Lambar CAS | 103639-04-9 (Dihydrate) |
Abubuwan da suka dace da CAS RN | 99614-02-5 (Base) & 99614-01-4 (Anhydrous) |
Tsarin kwayoyin halitta | C18H19N3O·HCl·2H2O |
Nauyin Kwayoyin Halitta | 365.86 g/mol |
Matsayin narkewa | 176.0 zuwa 180.0 ℃ |
M | Zafi Sensitive |
Ruwan Solubility | Mai narkewa a cikin Ruwa (> 5 mg/ml) |
Adana Yanayin. | Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃) |
COA & MSDS | Akwai |
Alamar | Ruifu Chemical |
Abubuwa | Ka'idojin dubawa | Sakamako |
Bayyanar | Fari zuwa Kashe-White Crystalline Foda | Ya bi |
Ganewa | ||
1. UV | Max 209, 248, 267, 310nm | Cancanta |
2. Bakan IR | Yayi daidai da Tsarin | Cancanta |
3. Wariya na Chloride | Ra'ayin Gaba | Cancanta |
Ruwa ta Karl Fischer | 9.0 ~ 10.5% | 9.7% |
Ragowa akan Ignition | ≤0.10% | 0.03% |
Karfe masu nauyi (Pb) | ≤10ppm | <10ppm |
Abubuwan da suka danganci Ondansetron C | ≤0.20% | 0.09% |
Abubuwan da ke da alaƙa da Ondansetron D | ≤0.10% | 0.04% |
Imidazole | ≤0.20% | 0.02% |
2-Methylimidazole | ≤0.20% | 0.02% |
Abubuwan da ke da alaƙa da Ondansetron A | ≤0.20% | 0.05% |
Sauran Rashin Tsabtace Guda Daya da Ba'a Sani ba | ≤0.10% | 0.07% |
Jimlar ƙazanta | ≤0.50% | 0.29% |
Residual Solvent | ||
Ethanol | ≤5000ppm | 240ppm ku |
Assay | 98.0 ~ 102.0% (Lissafta akan tushen anhydrous) | 99.81% |
Kammalawa | An gwada samfurin kuma ya dace da ƙayyadaddun bayanai |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin akwati da aka rufe sosai.Ajiye a cikin sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Fa'idodi?Babban inganci, farashi mai araha, sabis na ƙwararru da tallafin fasaha, bayarwa da sauri.
inganciTabbaci?Tsananin kula da ingancin inganci.Kayan aikin ƙwararru don bincike sun haɗa da NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, gwajin ƙayyadaddun ƙwayoyin cuta, da sauransu.
Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
MOQ?Babu MOQ.Karamin tsari abin karɓa ne.
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Lambobin haɗari
R25 - Mai guba idan an haɗiye shi
R36/37/38 - Haushi da idanu, tsarin numfashi da fata.
Bayanin Tsaro
S45 - Idan akwai haɗari ko kuma idan kun ji rashin lafiya, nemi shawarar likita nan da nan (nuna alamar a duk lokacin da zai yiwu.)
S37/39 - Saka safofin hannu masu dacewa da kariya / ido
S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita.
ID na UN 2811 6.1/PG 3
WGK Jamus 3
Saukewa: RTECS FE6375500
Farashin 29339900
Matsayin Hazard 6.1(a)
Rukunin tattarawa II
Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) ƙayyadaddun antagonist mai karɓar serotonin (5-HT3).Antiemetic.Ana amfani da Ondansetron Hydrochloride Dihydrate don hana tashin zuciya da amai wanda zai iya faruwa ta hanyar tiyata, chemotherapy, ko maganin radiation.5-HT3 antagonists receptor antagonists a cikin Ondansetron sune magungunan farko da ake amfani da su don magancewa da kuma hana cutar chemotherapy-jawo tashin zuciya da amai da tashin zuciya da amai da radiotherapy, ta hanyar toshe ayyukan sinadarai a cikin jiki.Amfanin yana da kyau fiye da metoclopramide yayin da ƙasa da kwanciyar hankali fiye da cyclizine ko droperidol.Duk da haka, yana da ɗan tasiri akan amai da ciwon motsi ya haifar.Ana iya ba da shi ta baki, ta hanyar allura a cikin tsoka ko cikin jijiya.
Ondansetron da Granisetron, Dolasetron sune magungunan antiemetics na asibiti guda uku da aka saba amfani da su, ondansetron shine mai hana mai karɓar mai karɓa na serotonin (5-HT3) wanda ke juyawa da zaɓi, don α1, α2, β1, β2-adrenergic masu karɓa da histamine H1, H2 masu karɓa, shi. yana da ƙaramin sakamako, don masu karɓar H, masu karɓa na tsakiya da na gefe dopaminergic, ba shi da wani sakamako mai ƙin yarda, yana iya kashe maganin cutar sankara da tashin zuciya da amai.Idan aka kwatanta da metoclopramide, tasirin sa na antiemetic ya fi ƙarfi kuma ba shi da halayen extrapyramidal.Don amai da cisplatin ya haifar, cyclophosphamide, doxorubicin, da dai sauransu zai iya haifar da sakamako mai sauri da ƙarfi.Ya dace ba kawai don maganin tashin zuciya da amai da ke haifar da chemotherapy na cytotoxic da radiation farfesa ba, har ma don rigakafi da maganin tashin zuciya da amai da tiyata ke jawo.Ondansetron yana aiki azaman hanyar wucewa tsakanin jijiyar visceral afferent da aka kunna a cikin gastrointestinal tract da cibiyar amai a cikin kashin baya, wanda ke haifar da diaphragm da motsin tsokoki na ciki.Chemotherapy da radiation far iya haifar da hanji 5-HT saki da kuma haifar da vagus jijiya ruri ta 5-HT3 mai karɓa, wanda ya sa amai reflex.Wannan samfurin yana toshe wannan reflex da ke faruwa, a lokaci guda yana toshe amai da ke haifar da aikin tsakiya.Hanyar game da tashin zuciya da amai ba a sani ba.Ondansetron a hade tare da dexamethasonecan na iya haɓaka tasirin anti-emetic.
Wannan yana haifar da fitowar afferent na vagal, yana haifar da amai.A cikin ɗaure ga masu karɓa na 5-HT3, ondansetron yana toshe haɓakawar serotonin, saboda haka amai, bayan abubuwan haɓakawa na emetogenic kamar cisplatin.Ciwon kai shine mafi yawan lokuta da aka ruwaito mummunan sakamako na waɗannan magunguna.
Guba ta hanyar jijiya. Tasirin tsarin ɗan adam ta hanyar jijiya: jaundice.Lokacin zafi don bazuwa yana fitar da tururi mai guba na NOx.
An yi amfani da shi azaman maganin hana kumburi lokacin da magungunan antiemetic na al'ada ba su da tasiri, kamar lokacin gudanar da cisplatin ko don wasu abubuwan da ke haifar da amai mara nauyi.Yin amfani da ondansetron a cikin kuliyoyi yana da ɗan rikici kuma wasu jihohi bai kamata a yi amfani da shi a cikin wannan nau'in ba.
Mu'amalar ƙwayoyi Mai yuwuwar mu'amala mai haɗari tare da wasu magunguna.
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-daya.
1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-daya.
Daidaitaccen bayani | Dilution | Hankali (µg RS a kowace ml) | Kashi (%, don kwatanta da samfurin gwaji) |
A | (1 cikin 5) | 50 | 0.4 |
B | (1 cikin 10) | 25 | 0.2 |
C | (1 cikin 20) | 12.5 | 0.1 |
Maganin Gwaji-Narke daidaitaccen adadin Ondansetron Hydrochloride a cikin methanol don samun mafita mai ɗauke da 12.5 MG kowace ml.Tsari- dabam a yi amfani da 20 µL na maganin gwajin, 20 µL na kowane daidaitaccen bayani, da 20 µL na maganin Ƙaddamarwa zuwa farantin chromatographic na bakin ciki (duba Chromatography).621) mai rufi da 0.25-mm Layer na chromatographic silica gel cakuda.Ƙirƙirar chromatogram a cikin tsarin narkewa wanda ya ƙunshi cakuda chloroform, ethyl acetate, methanol, da ammonium hydroxide (90:50:40:1) har sai da gaban sauran ƙarfi ya motsa kusan kashi uku cikin huɗu na tsawon farantin.Cire farantin daga ɗakin, yi alama a gaban sauran ƙarfi, kuma ba da damar sauran ƙarfi ya ƙafe.Bincika farantin a ƙarƙashin hasken UV mai ɗan gajeren zango: an sami cikakken ƙuduri na sassa uku na wurin warware matsalar.Kwatanta ƙarfin kowane tabo na biyu da aka gani a cikin chromatogram na maganin gwajin tare da na manyan tabo a cikin chromatograms na daidaitattun mafita: kowane tabo na biyu daga chromatogram na maganin gwajin yana da ƙimar RF daidai da na babba mafi girma. tabo na Maganin Ƙaddamarwa bai fi girma ko mafi tsanani fiye da ainihin tabo da aka samu daga Standard bayani A (0.4%);kuma babu wani wuri na biyu daga chromatogram na maganin gwajin da ya fi girma ko mafi tsanani fiye da babban tabo da aka samu daga Standard solution B (0.2%).
a cikin abin da C shine maida hankali, a cikin MG kowace ml, na USP Ondansetron Hydrochloride RS a cikin daidaitaccen bayani;W shine nauyin, a cikin MG, na Ondansetron Hydrochloride da aka ɗauka don shirya maganin gwajin;F shine yanayin mayar da martani na dangi na ƙazanta kamar yadda aka bayyana a cikin tebur mai biye;ri shine yanki kololuwa ga kowane kazanta a cikin maganin gwajin;kuma rS shine yanki mafi girma na ondansetron da aka samu daga Ma'auni na Ma'auni: ya dace da buƙatun da aka bayar a cikin tebur mai biye.
Sunan Haɗin Kai | Lokacin Tsayawa Dangi | Dan uwa Martani Factor | Iyaka (%) |
---|---|---|---|
Abubuwan da ke da alaƙa da Ondansetron C | kusan 0.32 | 1.2 | 0.2 |
Abubuwan da ke da alaƙa da Ondansetron D* | ku 0.34 | - | 0.1 |
Imidazole | ku 0.49 | 0.3 | 0.2 |
2-methylimidazole | ku 0.54 | 0.4 | 0.2 |
Ondansetron | 1.0 | - | - |
Abubuwan da ke da alaƙa da Ondansetron A | kusan 1.10 | 0.8 | 0.2 |
Ba a sani ba | - | 1.0 | 0.1 |
Jimlar | - | - | 0.5 |
* Ƙididdigewa a cikin gwaji don Iyakar abubuwan da ke da alaƙa da ondansetron D. |
wanda C shine maida hankali, a cikin MG da ml, na USP Ondansetron Hydrochloride RS a cikin Shirye-shiryen Standard;da rU da rS sune wuraren kololuwar da aka samu daga shirye-shiryen Assay da Daidaitaccen shiri, bi da bi.
Hanyar 1: Bayan amsawar 2-Bromoaniline da1,3-Cyclohexanedione, An samo asali na tetrahydrocarbazole, kuma ana samun fili (III) ta hanyar amsawa tare da dimethylamine da diformaldehyde, da kuma gabatar da dimethylaminomethyl a matsayi na 2.3.80G na fili (III) an amsa tare da methyl iodide don ba da 5.72g na fili (IV) ta hanyar quaternizing sashin amino rukuni na gefe yayin gabatar da ƙungiyar methyl a matsayi 9. 2.0g na fili (IV) da 2-methyl-1h -imidazole an amsa a cikin dimethylformamide tare da motsawa a 95 ℃.Don samun 0.60G na Ondansetron.
Hanyar 2: Halin cyclohexanone da phenylhydrazine sun ba da tetrahydrocarbazole a cikin 85% yawan amfanin ƙasa.Narke shi a cikin tetrahydrofuran da ruwa, ƙara 2,3 Dropwise a 0 °c a cikin nitrogen, Maganin 5, 6-tetrachloro-1,4-benzoquinone a cikin tetrahydrofuran an motsa shi don ba da samfurin oxidation (II) a cikin 67.4% yawan amfanin ƙasa.Compound (II), ethanol, maida hankali hydrochloric acid, paraformaldehyde da dimethylamine hydrochloride aka refluxed tare.Bayan jiyya, samfurin (V) an samo shi ta ƙara mai da hankali hydrochloric acid zuwa acetone da motsawa a 50 ℃.A cikin 71.7% yawan amfanin ƙasa.An mayar da martani (V) da 2-methylimidazole a cikin ruwa a 110 ℃.Don samun fili (VI) a cikin 70.9% yawan amfanin ƙasa.An zuga mahadi (VI), methyl iodide da potassium carbonate a dakin da zafin jiki har sai dattin ya ɓace.An zuba shi a cikin ruwa, an motsa shi, an tace, an wanke shi da ruwa, kuma an sake yin amfani da shi daga methanol don samun ondansetron a cikin kashi 57.2% na yawan amfanin ƙasa.Narkar da shi a cikin cakuda acetone da ruwa, Ta ƙara maida hankali hydrochloric acid zuwa dauki, ondansetron hydrochloride dihydrate an samu tare da yawan amfanin ƙasa na 92.6%.
Hanyar 3: fili (II), potassium carbonate, acetone da dimethyl sulfate an motsa su a dakin da zafin jiki.An samu mahadi (VII) a cikin yawan amfanin ƙasa na 91%.An narkar da mahadi (VII) a cikin ethanol kuma an ƙara cakuda paraformaldehyde na ɗan adam da dimethylamine hydrochloride a cikin sassan ƙarƙashin reflux.Refluxing.Bayan jiyya, an samo fili (VIII) a cikin 67% yawan amfanin ƙasa.(Viii) narkar da a cikin anhydrous ethanol, hydrogen chloride gas, hydrochloride.An ƙara hydrochloride a cikin ruwa kuma an ƙara 2 a 50 ℃.Methylimidazole, refluxing ondansetron, samar da 70%.An narkar da shi a cikin isopropanol, ruwa da hydrochloric acid mai mahimmanci, kuma an zuga shi a dakin da zafin jiki don samun ondansetron hydrochloride dihydrate a cikin yawan amfanin ƙasa na 90.5%.