Palbociclib CAS 571190-30-2 Tsarkake>99.5% (HPLC) Kamfanin API
Ruifu Chemical Supply Palbociclib Matsakaici masu dangantaka:
Palbociclib CAS 571190-30-2
5-Bromo-2,4-Dichloropyrimidine CAS 36082-50-5
5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8
tert-Butyl 4-(6-Nitropyridin-3-yl) piperazine-1-Carboxylate CAS 571189-16-7
tert-Butyl 4-(6-Amino-3-Pyridyl)piperazine-1-Carboxylate CAS 571188-59-5
6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pyrimidin-7(8H) -daya CAS 1016636-76-2
2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d] pyrimidin-7-daya CAS 1013916-37-4
Sunan Sinadari | Palbociclib |
Makamantu | PD-0332991;Otava-Bb 1115529;Ibrance |
Lambar CAS | 571190-30-2 |
Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
Tsarin kwayoyin halitta | Saukewa: C24H29N7O2 |
Nauyin Kwayoyin Halitta | 447.54 |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Fari ko Kashe-Farin Foda |
1H NMR Spectrum | Daidaita Da Tsarin |
HPLC | Daidaita Da Tsarin |
Abubuwa masu alaƙa | |
Rashin Tsabtace Mutum | <0.50% |
Jimlar ƙazanta | <1.00% |
Asara akan bushewa | <0.50% |
Ragowa akan Ignition | <0.10% |
Karfe masu nauyi | <10ppm |
Tsarkake / Hanyar Bincike | > 99.5% (HPLC) |
Matsayin Gwaji | Matsayin Kasuwanci |
Amfani | API, A cikin Maganin Ciwon Kansa |
Kunshin: Bottle, Aluminum tsare jakar, 25kg / kwali Drum, ko bisa ga abokin ciniki ta bukata
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske da danshi
Palbociclib (CAS: 571190-30-2) shine mai hanawa kinase mai dogaro da cyclin (CDK) ta baka tare da yuwuwar aikin antineoplastic.Palbociclib ya zaɓi ya hana cyclin-dependent kinase 4 (CDK4) da 6 (CDK6), ta haka yana hana retinoblastoma (Rb) furotin phosphorylation a farkon lokacin G1 wanda ke haifar da kama sake zagayowar tantanin halitta.Wannan yana hana kwafin DNA kuma yana rage haɓakar ƙwayoyin ƙari.Palbociclib shine wakilin farko na sabon rukunin magunguna na masu hana kinase masu dogaro da cyclin.Wannan tasirin yana iyakance yaduwar tantanin halitta (ci gaban sel da rarrabuwa).Ana amfani da shi azaman wakili na antineoplastic a cikin ci gaba ko ciwon daji na nono.