Posaconazole CAS 171228-49-2 API Factory Triazole Wakilin Antifungal Babban inganci
Samar da masana'anta Posaconazole Matsakaici masu alaƙa, Samar da Kasuwanci
Posaconazole CAS 171228-49-2
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Sunan Sinadari | Posaconazole |
Makamantu | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R) -5- (2,4-Difluorophenyl) -5- (1,2,4-triazol-1-ylmethyl) oxolan-3-yl] methoxy]phenyl] piperazin-1-yl] phenyl] -2-[(2S,3S) -2-hydroxypentan-3-yl] -1,2,4-triazol-3-daya |
Lambar CAS | 171228-49-2 |
Lambar CAT | RF-API77 |
Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
Tsarin kwayoyin halitta | Saukewa: C37H42F2N8O4 |
Nauyin Kwayoyin Halitta | 700.78 |
Yawan yawa | 1.36 g/cm 3 |
Solubility | Mai narkewa a cikin DMSO, Mai narkewa cikin Ruwa |
Yanayin jigilar kaya | An aika Karkashin Zazzabin yanayi |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Fari zuwa Kashe-White Crystalline Foda |
Identification A | IR: Bakan samfurin infrared ya kamata ya yi daidai da na abin da ake tunani |
Identity B | Lokacin riƙe HPLC kama da abin tunani |
Matsayin narkewa | 167.0 ~ 171.0 ℃ |
Takamaiman Juyawa [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Ruwa (KF) | ≤1.0% |
Ragowa akan Ignition | ≤0.10% |
Abubuwa masu alaƙa | |
HT 909-24 | ≤0.20% |
Duk wani Rashin Tsabtace Mutum | ≤0.10% |
Jimlar ƙazanta | ≤1.0% |
Ragowar Magani | |
Methanol | ≤3000ppm |
Methyl tert-Butyl Ether | ≤5000ppm |
isopropanol | ≤5000ppm |
Dimethyl sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Assay | 98.0% ~ 102.0% (Lissafi akan busasshiyar tushe) |
Karfe masu nauyi | ≤10ppm |
Isomer | Enantiomer ≤0.10% |
Kowane Mutum Najasa ≤0.10% | |
Jimlar ƙazanta ≤1.0% | |
Matsayin Gwaji | Matsayin Kasuwanci;USP;BP;EP Standard |
Amfani | API, Triazole Antifungal Agent |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Posaconazole (CAS 171228-49-2), babban bakan ne, tsara na biyu, triazole fili tare da aikin antifungal, wanda aka ƙaddamar a cikin Burtaniya, shine sabon memba na rukunin azole na maganin rigakafi don isa kasuwa.Ana nuna shi don jiyya da rigakafi na kewayon cututtukan cututtukan fungal masu haɗari, gami da aspergillosis, fusariosis, chromoblastomycosis, mycetoma, da coccidiomycosis a cikin marasa lafiya waɗanda ba su da ƙarfi, ko rashin haƙuri, daidaitaccen jiyya tare da amphotericin B da / ko itraconazole.A cikin Amurka, an yarda da rigakafin cututtukan Aspergillus da Candida masu kamuwa da cuta a cikin marasa lafiya masu shekaru 13 waɗanda ke cikin haɗarin haɓaka waɗannan cututtukan saboda ƙarancin rigakafi.Bugu da ƙari, an yarda da shi don maganin oropharyngeal candidiasis.Posaconazole yana da faɗaɗa aikin bakan na sauran mambobi na azole antifungals.Baya ga m aiki a kan refractory lokuta na aspergillosis da fluconazole-resistant Candida, yana nuna aiki a kan Zygomycetes.Posaconazole magani ne na maganin fungal na triazole wanda aka sayar a Amurka ta Schering-Plough a ƙarƙashin sunan kasuwanci Noxafil.