PyBrOP CAS 132705-51-2 Tsarkake>99.0% (HPLC) Reagents Masu Haɗin Haɗin Ma'adinai

Bromotripyrrolidinophosphonium Hexafluorophosphate (PyBrOP) (CAS: 132705-51-2) shine tsayayyen reagent don haɗakar N-Methylamino acid a cikin haɗin peptide.Ana amfani dashi don haɓakar depsipeptides.
PyBroP shine reagent peptide coupling reagent wanda aka yi amfani dashi a cikin haɗin ƙwayar ƙwayar ƙwayar cuta ta musamman peptide-peptoid hybrid prodrugs.Reagent peptide coupling reagent mai amsawa wanda ya dace da α, α-dialkyl amino acid.
Mai haɓakawa don: kira na amides na farko, haɗin kai tsaye na phosphonium giciye, arylation kai tsaye, samuwar pyrrolidide ta hanyar haɗin haɗin gishiri na phosphonium.
PyBroP gishirin phosphonium ne da ake amfani da shi a cikin haɗin gwiwar sunadarai na peptide, kwatankwacin PyCloP.PyBroP yana nuna babban inganci a cikin haɗin gwiwar N-methylated amino acids da α, α-amino acid ɗin da ba su canza ba, tare da kyakkyawan amfanin gona, babu epimerisation da saurin amsawa.PyBroP tsayayye ne mai ƙarfi wanda za'a iya amfani dashi a cikin hanyar tukunya ɗaya kuma yana narkewa a cikin abubuwan da aka saba amfani dashi don haɗakar da sunadarai na peptide.PyBroP ya samo asali ne na phosphonium coupling reagent BOP amma yana ƙunshe da ƙwayar pyrrolidine a maimakon dimethylamine na BOP.Manufar da ke bayan ƙirar PyBroP ita ce hana samuwar samfurin HMPA mai guba mai guba da ƙwayar cuta wanda aka samar tare da BOP, amma tare da kwatankwacin wasan kwaikwayo.
Ana iya amfani da PyBroP azaman reagent mai haɗawa: Don Suzuki-Miyaura haɗin haɗin gwiwar phenols da arylboronic acid don haɗa biaryls da heterobiaryls.Don yin aiki da pyrimidine (wanda aka haɗa daga 3,4-dihydropyrimidin-2 (1H) -ones (DHPMs) ta hanyar Kappe dehydrogenation) ta hanyar amfani da nucleophiles daban-daban.Don haɗar foramidines ta hanyar haɗawa da amines na farko da N, N-diisopropylethylamine.Hakanan za'a iya amfani da shi azaman reagent mai kunnawa: Don kunna haɗin C-OH a cikin keɓaɓɓun kekuna masu tautomerizable don samar da gishirin phosphonium wanda ke taimakawa Sonogashira haɗakar kekuna tare da alkynes iri-iri.Don kunna tukunyar tukunya ɗaya na CO bond a cikin phenols da ƙarin haɗin kai tare da phosphine oxide ko phosphite don samar da haɗin gwiwar CP.