(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R) -Me-CBS Catalyst CAS 112022-83-0 Tsaftace Na gani ≥98.0%

Samar da Mai ƙira;Babban inganci da Farashin Gasa

CBS Catalysts
(S)-(-)-2-Methyl-CBS-oxazaborolidine;(S)-Me-CBS Catalyst (kamar 1mol/L a cikin Toluene);Saukewa: 112022-81
(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R) -Me-CBS Catalyst (kamar 1mol / L a cikin Toluene);Saukewa: 112022-83-0

CBS Catalyst
Mai kara kuzari na CBS ko Corey–Bakshi–Shibata mai kara kuzari shine mai asymmetric catalyst wanda aka samu daga proline.Yana samun amfani da yawa a cikin halayen kwayoyin halitta kamar ragewar CBS, halayen Diels-Alder da (3+2) cycloadditions.Proline, wani fili na chiral da ke faruwa a zahiri, yana samuwa cikin sauƙi kuma mai rahusa.Yana jujjuya sitiriyon sa zuwa mai kara kuzari wanda hakanan yana iya fitar da kwayar halitta ta hanyar zaɓin zaɓi zuwa ɗaya daga cikin masu haɓakawa biyu masu yuwuwa.Wannan zaɓin ya samo asali ne saboda rashin ƙarfi a cikin yanayin canji wanda ke tasowa don enantiomer ɗaya amma ba don ɗayan ba.

CBS Catalysts don Rage Asymmetric da Haɗin Asymmetric
An yi amfani da mai kara kuzari na CBS (Corey-Bakshi-Shibata) oxazaborolidine a cikin rage asymmetric na ketones na prochiral.Sauran aikace-aikacen sun haɗa da haɗin enantioselective na α-hydroxy acid, α-amino acid, C2-symmetrical ferrocenyl diols, da propargyl alcohols.

(R) - (+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol/L a cikin Toluene) CAS: 112022-83-0 ana iya amfani dashi azaman mai haɓakawa a cikin rage asymmetric borane na perfluoroalkyl ketones.Sauran aikace-aikacen sun haɗa da haɗin enantioselective na α-hydroxy acid, α-amino acid, C2 symmetrical ferrocenyl diols, da propargyl alcohols.Hakanan ana amfani dashi a cikin raguwar desymmetrizing wanda ke haifar da (S) -4-hydroxycyclohexenone.Yana da amfani a samar da stereospecific motifs kamar α-hydroxy acid, α-amino acid, symmetrical ferrocenyl diols da propargyl alcohols.

(R)-(+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol/L a cikin Toluene) CAS: 112022-83-0 shine mai kara kuzari na organoboron wanda aka yi amfani da shi a cikin haɗin gwiwar kwayoyin halitta.Wannan mai kara kuzari, wanda Itsuno da Elias James Corey suka kirkira, an samar dashi ta hanyar dumama (R)-(+)- (diphenylhydroxymethyl) pyrrolidine tare da trimethylboroxine ko methylboronic acid.Yana da wani kyakkyawan kayan aiki don kira na alcohols a high enantiomeric rabo.Gabaɗaya, 2-10 mol% na wannan mai haɓakawa ana amfani da shi tare da borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N, N-diethylaniline, ko diborane azaman tushen borane.An yi amfani da raguwar Enantioselective ta amfani da chiral oxazaborolidine catalysts a cikin haɗin magungunan kasuwanci kamar ezetimibe da aprepitant.