(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Tsarkake ≥99.7% (GC) Chiral Tsarkake
Samar da Mai ƙira;Babban Tsafta da Farashin Gasa
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Matsakaicin Panipenem (CAS 87726-17-8) da Darifenacin hydrobromide (CAS 133099-07-7)
| Sunan Sinadari | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Makamantu | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Lambar CAS | 104706-47-0 |
| Lambar CAT | Saukewa: RF-CC102 |
| Tsarkake / Hanyar Bincike | ≥98.0% (GC) |
| Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
| Tsarin kwayoyin halitta | Saukewa: C4H10ClNO |
| Nauyin Kwayoyin Halitta | 123.58 |
| Matsayin narkewa | 107.0 ~ 111.0 °C |
| Solubility a cikin Ruwa | Kusan Gaskiya |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Kashe-White zuwa Pale Brown Crystalline Foda |
| Tsarkake / Hanyar Bincike | ≥99.7% (GC) |
| Chiral Tsafta | ≥99.7% da |
| Ragowa akan Ignition | ≤0.50% |
| Takamaiman Juyawa [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Duk wani Rashin Tsabtace Mutum | ≤0.20% |
| Jimlar ƙazanta | ≤0.30% |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | Matsakaicin Magunguna;Chiral mahadi |
Hanyar Bincike
Kayan aiki: Kayan aikin GC (Shimadzu GC-2010)
Shafin: DB-17 Agilent 30mX0.53mmX1.0μm
Zafin tanda na farko: 80 ℃
Lokacin farko 2.0min
Matsakaicin 15 ℃/min
Zafin tanda na ƙarshe: 250 ℃
Lokacin ƙarshe 20min
Mai ɗaukar iskar Nitrogen
Yanayi Constant kwarara
Guda 5.0ml/min
Raba rabo 10:1
Injector zafin jiki: 250 ℃
Zazzabi mai ganowa: 300 ℃
Girman allura 1.0μL
Kariyar da ya kamata a yi kafin bincike:
1. Yanayin yanayin a 240 ℃ don mafi ƙarancin 30minutes.
2. A wanke sirinji da tsaftataccen layin allura da kyau don cire gurɓatattun binciken da aka yi a baya.
3. A wanke, bushe da cika diluent a cikin kwalabe na sirinji.
Shirye-shiryen diluent:
Shirya 2% w/v sodium hydroxide bayani a cikin ruwa.
Daidaitaccen shiri:
Auna kimanin 100mg na (R) -3-hydroxyprolidine hydrochloride misali a cikin vial, ƙara 1mL na diluent kuma narkar da.
Shirye-shiryen gwaji:
Auna kimanin 100mg na samfurin gwaji a cikin vial, ƙara 1ml na diluent kuma narke.Shirya cikin kwafi.
Tsari:
Allurar blank (diluent), daidaitaccen shiri da shirye-shiryen gwaji ta amfani da yanayin GC na sama.Yi watsi da kololuwa saboda babu komai.Lokacin riƙewa na kololuwa saboda (R) -3-hydroxyprolidine shine kusan 5.0min.
Lura:
Bayar da sakamakon a matsayin matsakaici
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Shanghai Ruifu Chemical Co., Ltd. shine jagoran masana'anta kuma mai ba da kaya na (R)-(-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) tare da inganci mai inganci, ana amfani dashi ko'ina a cikin haɓakar ƙwayoyin cuta, haɓakar magungunan magunguna. da Active Pharmaceutical Ingredient (API) kira.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) matsakaici ne yawanci a cikin kira na Panipenem (CAS 87726-17-8) da Darifenacin hydrobromide (CAS 133099-07-7).
(R) - (-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) wani nau'in chiral hydroxy ne na pyrrlodine da aka yi amfani dashi a cikin shirye-shiryen mahadi masu aiki na niologically kamar muscarinic antagonists receptor antagonists da antimicrobial agents.
Hanyar Magana na (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile an amsa tare da trimethyl chlorosilane a cikin dichloromethane kaushi don samun (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine sa'an nan kuma hydrogenated a kan Pd / C mai kara kuzari.A ƙarshe, an samo samfurin (R) -3-hydroxypyrrolidine hydrochloride ta hanyar mayar da hankali ga maganin hydrochloric acid kuma an cire ƙungiyar kariya ta trimethylsilyl.
