Ramelteon Matsakaici 12 CAS 1053239-39-6 Tsafta > 98.0% (HPLC)
Jagoran Mai ƙira da mai bayarwa, Matsakaicin Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-daya CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2- (2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
Sunan Sinadari | 2- (2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride |
Makamantu | Ramelteon Matsakaici 12;Ramelteon Stage-2 Rashin Tsabta;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B] Furan-8-Ethanamine Hydrochloride |
Lambar CAS | 1053239-39-6 |
Lambar CAT | Saukewa: RF2887 |
Matsayin Hannun jari | A cikin Hannun jari, Ma'aunin samarwa Har zuwa Ton |
Tsarin kwayoyin halitta | Saukewa: C13H18ClNO |
Nauyin Kwayoyin Halitta | 239.74 |
Matsayin narkewa | 165.0 ~ 167.0 ℃ |
Yawan yawa | 1.058± 0.06 g/cm3 |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Fari zuwa Kashe-Farin Tsayayyen Foda |
Tsarkake / Hanyar Bincike | 98.0% (HPLC) |
Asara akan bushewa | <1.00% |
Tsaftace Guda Daya | <1.00% |
Jimlar ƙazanta | <2.00% |
1 H NMR Spectrum | Daidaita Da Tsarin |
Matsayin Gwaji | Matsayin Kasuwanci |
Amfani | Matsakaicin Ramelteon (CAS: 196597-26-9) |
Kunshin: Bottle, Aluminum tsare jakar, 25kg / kwali Drum, ko bisa ga abokin ciniki ta bukata
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske da danshi
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2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl) ethanamine Hydrochloride (CAS: 1053239-39-6) shine matsakaicin Ramelteon (CAS: 196597- 26-9).Ba kamar yawancin jiyya na rashin barci ba waɗanda ke kaiwa ga hadaddun masu karɓa na GABA (g-aminobutyric acid), Ramelteon agonist ne na mai karɓar melatonin.Musamman ma, yana da babban zaɓi don ƙananan nau'ikan MT1 da MT2, waɗanda aka sanya su a cikin kiyaye rhythms na circadian, akan mai karɓar MT3 da ke da alhakin sauran ayyukan melatonin.Rashin kusancinsa don ba kawai hadaddun mai karɓar GABA ba har ma neurotransmitter, dopaminerigic, opiate, da masu karɓar benzodiazepine suna ba da shawarar ingantaccen bayanin martaba ba tare da yuwuwar cin zarafi na magungunan hypnotic waɗanda ke kaiwa ga waɗannan masu karɓa ba.Don haka, Ramelteon ba magani ne da aka tsara ba.Metabolites na farko sun haɗa da hydroxylation da oxidation zuwa nau'in carbonyl tare da metabolites na biyu sakamakon glucuronidation.Tun da CYP1A2 shine babban isozyme da ke cikin hanta metabolism na Ramelteon, bai kamata a sha shi tare da masu hana CYP1A2 masu ƙarfi ba, kamar fluvoxamine.Gudanar da haɗin gwiwa tare da ko dai ketoconazole (mai hana CYP3A4) ko fluconazole (mai hana CYP2C9 mai ƙarfi) ya haifar da ƙaruwa mai yawa a cikin AUC da Cmax, amma haɓakar haɓakawa da haɓakar ƙwayar plasma mai girma na Ramelteon ya hana buƙatar gyaran kashi.Sashin kunshin, duk da haka, yana gargaɗin marasa lafiya game da haɗin gwiwa tare da masu hana CYP3A4 masu ƙarfi da CYP2C9.Dangane da sakamakon gwajin asibiti, shawarar da aka ba da shawarar na Ramelteon shine 8mg ana ɗaukar shi a cikin mintuna 30 na zuwa barci.Bugu da ƙari, yin taka tsantsan na haɗin gwiwa tare da masu hana CYP, bai kamata a yi amfani da shi ba a cikin marasa lafiya da ciwon hanta mai tsanani.Abubuwan da ba su da kyau, waɗanda aka lura a cikin 5% na marasa lafiya a cikin nazarin asibiti, sun kasance rashin tausayi, damuwa, tashin zuciya, gajiya, ciwon kai, da rashin barci.