Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API High Quality
Samar da Kasuwancin Mai ƙera Remdesivir da Matsakaici masu alaƙa tare da Babban inganci
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy) phosphoryl) -L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy) phenoxyphosfinyl] -L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Matsakaici CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F] [1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1
Sunan Sinadari | Remdesivir |
Makamantu | GS-5734;2-ethylbutyl ((S)-((2R,3S,4R,5R)-5-(4-aminopyrrolo [2,1-f] [1,2,4]triazin-7-yl) -5-cyano -3,4-dihydroxytetrahydrofuran-2-yl) methoxy) (phenoxy) phosphoryl - L-alaninate |
Lambar CAS | 1809249-37-3 |
Lambar CAT | RF-API96 |
Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
Tsarin kwayoyin halitta | Saukewa: C27H35N6O8P |
Nauyin Kwayoyin Halitta | 602.58 |
Yawan yawa | 1.47± 0.1 g/cm3 |
Alamar | Ruifu Chemical |
Abu | Ƙayyadaddun bayanai |
Bayyanar | Fari zuwa Kashe-Farin Tsayayyen Foda |
Identification A | IR: Bakan samfurin infrared ya kamata ya yi daidai da na abin da ake tunani |
Identity B | Lokacin riƙe HPLC kama da abin tunani |
Takamaiman Juyawa | -19.0 ~ -22.0° |
Solubility | Solule a cikin Methanol, Mai Soluble a cikin Ethanol, Dan Soluble a cikin Acetonitrile, Mai Rashin narkewa cikin Ruwa |
Abubuwa masu alaƙa | |
Duk wani Rashin Tsabtace Mutum | ≤0.10% |
Jimlar ƙazanta | ≤1.0% |
RD-3.1 | ≤0.10% |
RD-C | ≤0.10% |
RD-D | ≤0.10% |
RD-E | ≤0.10% |
RP-Isomer | ≤0.10% |
Nitrophenol | ≤0.10% |
Ragowar Magani | |
Methanol Dichloride | ≤6000ppm |
Acetone | ≤5000ppm |
Isopropyl Alcohol | ≤5000ppm |
Acetonitrile | ≤410pm |
Dichloromethane | ≤600ppm |
Methyl tert Butyl Ether | ≤5000ppm |
Ethyl acetate | ≤5000ppm |
Tetrahydrofuran | ≤720ppm |
n-Heptane | ≤5000ppm |
Assay | 98.0% ~ 102.0% (Lissafi akan busasshiyar tushe) |
Jimlar Ƙididdigar Aerobic | |
Bacteria Aerobic | ≤100cfu/g |
Yisti da Mold | ≤10cfu/g |
E. Kwal | Korau |
Bacterial Endotoxin | ≤1.0EU |
Karfe masu nauyi | ≤20ppm |
Matsayin Gwaji | Matsayin Kasuwanci |
Amfani | API, COVID-19 |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Remdesivir (CAS 1809249-37-3), wanda aka sayar a ƙarƙashin sunan alamar Veklury, babban maganin rigakafin ƙwayar cuta ne wanda kamfanin biopharmaceutical na Gileyad Sciences ya haɓaka.Ana gudanar da shi ta hanyar allura a cikin jijiya.A lokacin cutar ta COVID-19, an yarda da remdesivir ko izini don amfani da gaggawa don kula da COVID-19 a cikin ƙasashe kusan 50.Sabunta jagororin daga Hukumar Lafiya ta Duniya a cikin Nuwamba 2020 sun haɗa da shawarar sharadi game da amfani da Remdesivir don maganin COVID-19.An samo asali ne na Remdesivir don magance cutar hanta ta C, kuma daga baya aka bincikar cutar ta Ebola da kuma cututtukan ƙwayoyin cuta na Marburg kafin a yi nazari a matsayin maganin cutar bayan kamuwa da cutar COVID-19.Mafi yawan sakamako masu illa a cikin masu sa kai masu lafiya shine haɓaka matakan jini na enzymes hanta (alama ta matsalolin hanta).Mafi yawan illar illa a cikin mutanen da ke da COVID-19 shine tashin zuciya.Abubuwan da ke haifar da lahani na iya haɗawa da kumburin hanta da kuma abin da ke da alaƙa da jiko tare da tashin zuciya, ƙarancin hawan jini, da gumi.Remdesivir prodrug ne wanda aka yi niyya don ba da damar isar da intracellular na GS-441524 monophosphate da biotransformation na gaba zuwa GS-441524 triphosphate, mai hana ribonucleotide analogue mai hanawa na kwayar cutar RNA polymerase.