Rivastigmine Tartrate CAS 129101-54-8 Assay 98.0 ~ 102.0
Shanghai Ruifu Chemical Co., Ltd. shine babban kamfani na Rivastigmine Tartrate (CAS: 129101-54-8) tare da babban inganci.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Rivastigmine Tartrate,Please contact: alvin@ruifuchem.com
| Sunan Sinadari | Rivastigmine Tartrate |
| Makamantu | Exelon;ENA-713;Rivastigmine L-Tartrate;Rivastigmine Hydrogen Tartrate;CS-118;S-Rivastigmine Tartrate;3- [(S) -1- (Dimethylamino) ethyl] phenyl N-Ethyl-N-Methylcarbamate L-Tartrate;N-Ethyl-N-Methylcarbamic Acid 3-[(S)-1- (Dimethylamino) ethyl] phenyl Ester L-Tartrate |
| Matsayin Hannun jari | A Stock, Kasuwancin Kasuwanci |
| Lambar CAS | 129101-54-8 |
| CAS mai alaƙa | 123441-03-2 |
| Tsarin kwayoyin halitta | C14H22N2O2 · C4H6O6 |
| Nauyin Kwayoyin Halitta | 400.43 g/mol |
| Matsayin narkewa | 124.0 zuwa 128.0 ℃ |
| Takamaiman Juyawa [a] 20/D | +4.0° zuwa +7.0° (C=5, methanol) |
| Solubility | Mai narkewa a cikin methanol |
| COA & MSDS | Akwai |
| Asalin | Shanghai, China |
| Alamar | Ruifu Chemical |
| Abubuwa | Ka'idojin dubawa | Sakamako |
| Bayyanar | Fari zuwa Kashe-White Crystalline Foda | Ya bi |
| Assay | 98.0 ~ 102.0% (akan Anhydrous Basis) | 99.8% |
| Ruwa ta Karl Fischer | ≤0.50% | 0.15% |
| Ragowa akan Ignition | ≤0.10% | 0.07% |
| Karfe masu nauyi (Pb) | ≤20ppm | <10ppm |
| phenol rashin tsarki | ≤0.30% | <0.30% |
| DPTTA | ≤0.15% | <0.15% |
| Haka kuma rashin tsarki | ≤0.15% | <0.15% |
| Karbamate Najasa | ≤0.15% | <0.15% |
| Tsabtace Ether | ≤0.15% | <0.15% |
| Duk Wani Najasa | ≤0.10% | <0.10% |
| Jimlar ƙazanta | ≤0.50% | <0.50% |
| R-Enantiomer | ≤0.30% | <0.30% |
| Infrared Spectrum | Daidai da Tsarin | Ya bi |
| 1H NMR Spectrum | Daidai da Tsarin | Ya bi |
| Kammalawa | An gwada samfurin kuma ya bi ka'idodin USP35 | |
Kunshin:Fluorinated Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye akwati sosai kuma a adana a wuri mai sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.
Rivastigmine Tartrate
C14H22N2O2 · C4H6O6 400.42
Ethylmethylcarbamic acid, 3-[(S) -1- (dimethylamino) ethyl] phenyl ester, (2R, 3R) -2,3-dihydroxybutanedioate;
(S) -3-[1- (Dimethylamino) ethyl] phenyl ethylmethylcarbamate, hydrogen tartrate [129101-54-8].
Rivastigmine 250.34 [123441-03-2].
BAYANI
Rivastigmine Tartrate ya ƙunshi NLT 98.0% da NMT 102.0% na adadin da aka yiwa alama na C14H22N2O2 · C4H6O6, ƙididdige shi akan tushen anhydrous.
GANO
• A. Ciwon Infrared <197K>
• B. Lokacin riƙewa na babban kololuwar samfurin samfurin ya dace da na tsarin dacewa da tsarin, kamar yadda aka samu a cikin gwaji don ƙazantattun kwayoyin halitta, Tsarin 2: Enantiomeric Tsabta.
ASSAY
• Tsari
Buffer: 8.6 mg/mL na monobasic ammonium phosphate.Daidaita tare da maganin ammonia zuwa pH na 7.0.
Lokacin wayar hannu: methanol, acetonitrile, da buffer (15:15:70)
Maganin dacewa da tsarin: 0.05 mg/mL kowannensu na USP Rivastigmine Mai alaƙa da haɗin gwiwa A RS da USP Rivastigmine Mai alaƙa Haɗin B RS a cikin Wayar hannu.
Daidaitaccen bayani: 0.2 mg/mL na USP Rivastigmine Tartrate RS a cikin Wayar hannu
Maganin samfurin: 0.2 mg/mL na Rivastigmine Tartrate a cikin Wayar hannu
Tsarin chromatographic
(Duba Chromatography <621>, Dacewar Tsarin.)
Yanayin: LC
Mai ganowa: UV 215 nm
Tushen: 4.6-mm × 25-cm;5-µm shiryarwa L7
Yawan gudu: 1.2 ml/min
Girman allura: 20µL
[Lura-Za a iya daidaita ƙimar kwarara zuwa 1.5 mL/min, idan an buƙata, don cimma shawarar riƙewar rivastigmine a kusan mintuna 10.]
Dacewar tsarin
Samfurori: Maganin dacewa da tsarin da daidaitaccen bayani
Abubuwan da suka dace
Resolution: NLT 1.5 tsakanin rivastigmine alaka fili A da rivastigmine alaka fili B, Tsarin dacewa bayani
Ƙimar ginshiƙi: NLT 5000 faranti na ka'idar, Magani mai mahimmanci
Halin wutsiya: NMT 3.0, Daidaitaccen bayani
Matsakaicin daidaitaccen dangi: NMT 2.0%, Daidaitaccen bayani
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Yi lissafin adadin C14H22N2O2 · C4H6O6 a cikin ɓangaren Rivastigmine Tartrate da aka ɗauka:
Sakamako = (rU/rS) × (CS/CU) × 100
rU = kololuwar amsa daga Maganin Samfurin
rS = kololuwar amsa daga daidaitaccen bayani
CS = maida hankali na daidaitaccen bayani (mg/mL)
CU = maida hankali na Maganin Samfurin (mg/mL)
Sharuɗɗan karɓa: 98.0% -102.0% akan tushen anhydrous
RASHIN ZUCIYA
Najasa Na Inorganic
• Ragowa akan ƙonewa <281>: NMT 0.1%
• Karfe masu nauyi, Hanyar II <231>: NMT 20 ppm
Najasa Na Halitta
• Hanya ta 1
Tsarin Wayar hannu da Maganin dacewa da tsarin: Ci gaba kamar yadda aka umarce shi a cikin Assay.
Daidaitaccen bayani: 1.0 µg/ml na USP Rivastigmine Tartrate RS a cikin Wayar hannu
Maganin samfurin: 1.0 mg/mL na Rivastigmine Tartrate a cikin Wayar hannu
Tsarin Chromatographic: Ci gaba kamar yadda aka umarce shi a cikin Assay.
(Duba Chromatography <621>, Dacewar Tsarin.)
Dacewar tsarin
Samfurori: Maganin dacewa da tsarin da daidaitaccen bayani
Abubuwan da suka dace
Resolution: NLT 1.5 tsakanin rivastigmine alaka fili A da rivastigmine alaka fili B, Tsarin dacewa bayani
Matsakaicin daidaitaccen dangi: NMT 10%, Daidaitaccen bayani
Nazari [Lura-Lokacin gudu shine sau 8 lokacin riƙewa na kololuwar rivastigmine.]
Samfurori: Daidaitaccen bayani da Samfurin bayani
Yi ƙididdige adadin kowane ƙazanta na kowane mutum a cikin ɓangaren Rivastigmine Tartrate da aka ɗauka:
Sakamako = (rU/rS) × (CS/CU) × (1/F) × 100
rU = kololuwar amsa ga kowane ƙazanta daga Maganin Samfurin
rS = kololuwar amsa daga daidaitaccen bayani
CS = maida hankali na USP Rivastigmine Tartrate RS a cikin daidaitaccen bayani (mg/mL)
CU = maida hankali na Rivastigmine Tartrate a cikin Samfurin bayani (mg/mL)
F = Matsayin martani na dangi (duba Shafukan Najasa 1)
Sharuɗɗan karɓa
Najasa ɗaya: Dubi Shafukan Najasa 1.
Jimlar ƙazanta: NMT 0.5%
Tebur Najasa 1
| Suna | Lokacin Tsayawa Dangi | Abubuwan Amsa Na Dangi | Sharuɗɗan karɓa NMT % |
| Tartrate | 0.18 | - | Rashin kula |
| Phenol rashin tsarki | 0.28 | 1.6 | 0.3 |
| DPTTAB | 0.46 | 0.83 | 0.15 |
| Kuma najasa | 0.57 | 1.2 | 0.15 |
| Rivastigmine | 1.0 | 1.0 | - |
| Carbamate najasa | 4.1 | 1.3 | 0.15 |
| Ether najasa | 6.5 | 1.4 | 0.15 |
| Duk wani kazanta | - | 1.0 | 0.1 |
a (S) -3-[1- (Dimethylamino) ethyl] phenol.
b (+)-Di- (p-toluoyl) -d-tartaric acid (abin da ke da alaƙa da rivastigmine A).
c (S) -3- [1- (Dimethylamino) ethyl] phenyl dimethylcarbamate (abin da ke da alaka da rivastigmine B).
d 3-Nitrophenyl ethyl (methyl) carbamate.
e (S) -N, N-Dimethyl-1-[3- (4-nitrophenoxy) phenyl] etanamine.
• Hanya ta 2: Tsaftar Enantiomeric
Buffer: Canja wurin 1.78 g na dibasic sodium phosphate dihydrate da 1.38 g na monobasic sodium phosphate a cikin faifan volumetric 1000-ml.Narke cikin kuma tsoma da ruwa zuwa girma.Daidaita tare da phosphoric acid zuwa pH na 6.0.
Lokacin wayar hannu: Canja wurin 20 ml na acetonitrile da 205 µL na N, N-dimethylotylamine zuwa flask ɗin 1000-mL, kuma tsarma tare da Buffer zuwa girma.
Daidaitaccen bayani: 0.1 µg/ml na USP Rivastigmine Tartrate R-Isomer RS a cikin Wayar hannu.
Maganin hankali: 0.05 µg/mL na USP Rivastigmine Tartrate R-Isomer RS a cikin Wayar Hannu, Madaidaicin bayani
Maganin dacewa da tsarin: 100 µg/mL na USP Rivastigmine Tartrate RS da 0.1 μg/mL na USP Rivastigmine Tartrate R-Isomer RS a cikin Wayar hannu lokaci
Maganin samfurin: 100 µg/mL na Rivastigmine Tartrate a cikin Wayar hannu
Tsarin chromatographic
(Duba Chromatography <621>, Dacewar Tsarin.)
Yanayin: LC
Mai ganowa: UV 200 nm
Tushen: 4.0-mm × 10-cm;Farashin L41
Yawan gudana: 0.5 ml/min
Girman allura: 20µL
Dacewar tsarin
Samfura: Daidaitaccen Magani, Maganin hankali, da Maganin dacewa da tsarin
Abubuwan da suka dace
Resolution: NLT 0.8 tsakanin kololuwar enantiomer, Maganin dacewa da tsarin
[Lura-Odarin haɓaka shine R-enantiomer, sannan babban rivastigmine, wanda shine S-enantiomer.]
Rarraba siginar-zuwa amo: NLT 10, Maganin hankali
Matsakaicin daidaitaccen dangi: NMT 10%, Daidaitaccen bayani
Bincike
Samfurori: Daidaitaccen bayani da Samfurin bayani
Yi lissafin adadin R-enantiomer a cikin ɓangaren Rivastigmine Tartrate da aka ɗauka:
Sakamako = (rU/rS) × (CS/CU) × 100
rU = kololuwar martani na R-enantiomer daga Maganin Samfurin
rS = kololuwar martani na R-enantiomer daga daidaitaccen bayani
CS = maida hankali na R-enantiomer a cikin daidaitaccen bayani (µg/ml)
CU = maida hankali na Rivastigmine Tartrate a cikin Samfurin bayani (µg/ml)
Sharuɗɗan karɓa: NMT 0.3% na R-enantiomer
MAKAMMAN JARRABAWA
• Ƙaddamar da Ruwa, Hanyar IA <921>: NMT 0.5%
KARIN BUKATA
• Marufi da Ajiye: Ajiye a cikin matsuguni, kuma adana a zafin daki.
• Matsayin Magana na USP <11>
USP Rivastigmine Tartrate RS
Abubuwan da ke da alaƙa da USP Rivastigmine A RS
Di-p-toluoyl-d-(+) - tartaric acid monohydrate.
C20H20O9 404.37
Abubuwan da ke da alaƙa da USP Rivastigmine B RS
N, N-Dimethylcarbamic acid-3-[1- (dimethylamino) ethyl] phenyl ester.
C13H20N2O2 236.32
USP Rivastigmine Tartrate R-Isomer RS
Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Misali?Yawancin samfurori suna ba da samfurori kyauta don ƙima mai kyau, farashin jigilar kaya ya kamata a biya ta abokan ciniki.
Binciken Masana'antu?Ma'aikata duba maraba.Da fatan za a yi alƙawari a gaba.
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ID na UN 2811 6.1 / PGII
WGK Jamus 3
Saukewa: FA9550000
Farashin 29242990
Matsayin Hazard 6.1
Rukunin tattarawa na III
Rivastigmine Tartrate (CAS: 129101-54-8) shine tartrate na rivastigmine, magani don maganin cutar Alzheimer.Rivastigmine wani nau'in physostigmine ne, wanda Novartis, Switzerland ya samu nasarar haɓaka shi a karon farko.Sunan kasuwanci shine exelon, kuma kwayoyin suna da tsarin benzyl carbamate, yana da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma mai kwakwalwa ta carbamate, wanda zai iya hana acetylcholinesterase da butyrylcholinesterase a lokaci guda, kuma yana inganta ƙwayar jijiyar cholinergic ta hanyar jinkirta lalata acetylcholine da aka saki ta hanyar cholinergic. neurons.Yana iya inganta tabarbarewar fahimi wanda ke shiga tsakani ta hanyar cholinergic, don haka inganta tasirin fahimi na marasa lafiya da cutar Alzheimer.Ƙarfin daurin furotin na plasma na rivastigmine yana da rauni, mai sauƙin wucewa ta hanyar shingen jini-kwakwalwa, kuma yana da babban zaɓi na zaɓin kwakwalwa.Ba zai iya zaɓin zaɓi kawai akan mafi yawan wuraren da ke da rauni na ƙwayar ƙwayar cuta da hippocampus ba, amma kuma ya fi dacewa ya hana manyan nau'ikan AChE a cikin kwakwalwa, wanda zai iya rage tasirin cututtukan cholinergic na gefe yayin samar da tasirin warkewa.Rabin rayuwar rivastigmine tartrate a cikin jiki gajere ne kuma lokacin aiki yana da tsayi.Ba kamar tacrine ba, wannan samfurin yana da tasirin hanawa mai ƙarfi akan enzyme G1 a cikin hippocampus da cortex.Ana amfani da shi a asibiti don kula da cutar Alzheimer mai sauƙi zuwa matsakaici, wanda ake zargi da cutar Alzheimer ko cutar Alzheimer.
1. A matsayin mai hana acetylcholinesterase, rivastigmine bicartrate zai iya inganta tasirin succinylcholine tsoka relaxant.Don haka, ya kamata a sami lokaci mai dacewa don dakatar da shan wannan samfurin kafin maganin sa barci.Ya kamata a haɗa wannan samfurin tare da wasu shirye-shiryen cholinergic ko anticholinergic, kuma ya kamata a yi taka tsantsan (duba [Mu'amalar Magunguna]).
2. Saboda tasirin magungunan su, masu hana cholinesterase na iya samun tasirin tashin hankali na jijiyoyi akan bugun zuciya.Kamar yadda yake tare da sauran magungunan cholinergic, dole ne a yi taka tsantsan lokacin da aka bai wa marasa lafiya da ke fama da ciwon sinus ko wani toshewar zuciya (duba Mummunan halayen).
3. Jin daɗin jijiya na Cholinergic na iya haifar da haɓakar ƙwayar ciki.Ko da yake ba a sami wata shaida mai mahimmanci da tabarbarewar alamomin da suka dace ba yayin lokacin gwaji na asibiti, marasa lafiya da ke da babban haɗarin ciwon ciki, irin su waɗanda ke da tarihin cututtukan ulcer ko waɗanda ke karɓar magani tare da magungunan anti-inflammatory marasa steroidal. ya kamata a yi amfani da hankali.
4. Kamar sauran masu hana cholinesterase, marasa lafiya da tarihin asma ko wasu cututtuka na huhu na huhu ya kamata a yi amfani da su tare da taka tsantsan.
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