Sorafenib CAS 284461-73-0 Tsarkakewa
Samar da Kasuwancin Sorafenib Tosylate da Matsakaici masu alaƙa:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4- (4-Aminophenoxy) -N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3- (Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Suna | Sorafenib |
| Makamantu | Sorafenib Free Base |
| Lambar CAS | 284461-73-0 |
| Lambar CAT | RF-API04 |
| Matsayin Hannun jari | A Hannun jari, Ma'aunin Samfuran Har zuwa Daruruwan Kilogram |
| Tsarin kwayoyin halitta | Saukewa: C21H16ClF3N4O3 |
| Nauyin Kwayoyin Halitta | 464.82 |
| Yawan yawa | 1.454± 0.06 g/cm3 |
| Solubility | Mai narkewa a cikin DMSO |
| Yanayin jigilar kaya | Yanayin yanayi |
| Alamar | Ruifu Chemical |
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari zuwa Kashe-Farin Foda |
| Tsarkake / Hanyar Bincike | ≥99.0% (HPLC) |
| Ganewa | H-NMR, MS |
| Asara akan bushewa | ≤1.0% |
| Ragowa akan Ignition | ≤0.10% |
| Tsaftace Guda Daya | ≤0.20% (HPLC) |
| Jimlar ƙazanta | ≤1.0% (HPLC) |
| Karfe masu nauyi | ≤20ppm |
| Bayyanar Magani | Yi daidai da Standard |
| Matsayin Gwaji | Matsayin Kasuwanci |
| Amfani | RCC & HCC |
Kunshin: Bottle, Aluminum tsare jakar, Kwali drum, 25kg / Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin kwantena da aka rufe a wuri mai sanyi da bushe;Kare daga haske, danshi da kamuwa da kwari.
Sorafenib Tosylate (CAS: 475207-59-1) wani sabon nau'i ne na magungunan rigakafin tumor da aka yi niyya da yawa, Kamfanin Magunguna na Bayer na Jamus ne ya ƙirƙira shi, kuma ya nuna faɗuwar aikin antitumor a cikin gwaje-gwajen dabbobi na asali.Ana samun Sorafenib a cikin allunan 200-MG don gudanar da baki kuma ana amfani dashi a cikin jiyya na RCC da HCC.Sorafenib Tosylate (CAS: 475207-59-1) na iya yin tasiri a lokaci guda tare da ƙwayoyin ƙwayar cuta da ƙwayar jini.Yana da tasirin antitumor sau biyu: yana iya toshe hanyoyin siginar siginar tantanin halitta wanda RAF/MEK/ERK ke shiga tsakani don hana haɓakar ƙwayar ƙwayar cuta kai tsaye, yayin da kuma yana hana VEGF da abubuwan haɓakar haɓakar platelet (PDGF) don hana samuwar sabon ƙwayar ƙwayar cuta. tasoshin, don haka a kaikaice yana hana haɓakar ƙwayar ƙwayar cuta.Sorafenib shine mai hana Raf-1 da B-RAF da kuma yawan tyrosine kinases.
