Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%

Takaitaccen Bayani:

Vitamin E Polyethylene Glycol Succinate

Synonyms: Vitamin E-TPGS;Tocofersolan

Saukewa: 9002-96-4

Assay D-alpha Tocopherol (C29H50O2): ≥25.0%

Bayyanar: Kashe-Fara zuwa Kodadden Rawaya mai ƙarfi

Vitamin E wanda aka samu, Babban inganci

Tuntuɓi: Dr. Alvin Huang

Wayar hannu/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Cikakken Bayani

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Tags samfurin

Bayani:

Shanghai Ruifu Chemical Co., Ltd. shine babban masana'anta na Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) tare da babban inganci.Ruifu Chemical na iya samar da isar da saƙo na duniya, farashi mai gasa, kyakkyawan sabis, ƙanana da adadi mai yawa akwai.Sayi Vitamin E-TPGS,Please contact: alvin@ruifuchem.com

Abubuwan Sinadarai:

Sunan Sinadari Vitamin E Polyethylene Glycol Succinate
Makamantu Vitamin E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;Alfa-Tocopherol Polyethylene Glycol Succinate
Matsayin Hannun jari A Stock, Sikelin Kasuwanci
Lambar CAS 9002-96-4
Tsarin kwayoyin halitta C33H54O5.(C2H4O)n
Matsayin narkewa 34.0 ~ 38.0 ℃
Yawan yawa 1.01g/cm 3
M Hankalin iska, Hasken Hannu, Mai Dashi
WGK Jamus 2
Adana Yanayin. Wuri Mai sanyi & Busassun wuri (2 ~ 8 ℃)
COA & MSDS Akwai
Misali Akwai
Iyalin Sinadari Vitamin E wanda aka samu
Alamar Ruifu Chemical

Ƙayyadaddun bayanai:

Abubuwa Ka'idojin dubawa Sakamako
Bayyanar Kashe-Fara zuwa Kodiri Yellow Waxy Solid
Ya bi
Identification (GC) Lokacin riƙewa na babban kololuwar samfurin samfurin ya dace da na daidaitaccen bayani Ya bi
Matsayin narkewa 34.0 ~ 38.0 ℃ 36.0 ~ 36.6 ℃
Assay D-alpha Tocopherol ≥25.0% (C29H50O2) 26.4%
Tocopherol kyauta ≤1.5% Ya bi
Takamaiman Juyawa ≥+24.0° + 24.5 °
Solubility a cikin Ruwa Za a iya narkar da samfurin 20g a cikin ruwan zãfi 80ml Share A cikin sa'o'i 3
Darajar acid ≤0.27ml (0.10 N Sodium Hydroxide) 0.22 ml
Karfe masu nauyi (Pb) ≤10ppm <10ppm
Arsenic (AS) ≤1pm <1ppm
Jagoranci ≤3pm <3pm
Mercury (Hg) ≤0.1pm <0.010pm
Ragowar Magani
Ethyl acetate ≤50ppm Ba a Gano ba
Ethanol ≤50ppm 23ppm ku
Jimlar Ƙididdigar Faranti ≤1000CFU/g <10CFU/g
Yisti da Molds ≤100CFU/g <10CFU/g
Salmonella Korau Korau
Escherichia Coli Korau Korau
Psendomonas Aeruginosa Korau Korau
Staphylococcus Aureus Korau Korau
Infrared Spectrum Yayi daidai da Tsarin Ya bi
Kammalawa An gwada samfurin kuma ya bi ƙayyadaddun da aka bayar

Kunshin/Ajiye/Jirgin ruwa:

Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye a cikin akwati da aka rufe sosai.Ajiye a cikin sanyi, bushe (2 ~ 8 ℃) da ma'ajin da ke da isasshen iska daga abubuwan da ba su dace ba.Kare daga haske da danshi.
Jirgin ruwa:Isar da shi zuwa duniya ta iska, ta FedEx / DHL Express.Bayar da isarwa cikin sauri kuma abin dogaro.

9002-96-4 - USP35 Standard:

BAYANI
Vitamin E Polyethylene Glycol Succinate wani cakuda ne da aka samar ta hanyar esterification na d-alpha tocopheryl acid succinate da polyethylene glycol.Cakudar ester ta ƙunshi da farko na mono-esterified polyethylene glycol da ƙaramin adadin di-esterified polyethylene glycol.Ya ƙunshi NLT 25.0% na d-alpha tocopherol (C29H50O2).
GANO
• A. Gas Gwajin Ganewar Chromatographic
Analysis: Ci gaba kamar yadda aka umarce shi a cikin gwaji don abun ciki na Alpha Tocopherol.
Sharuɗɗan karɓa: Lokacin riƙewa na babban kololuwar maganin Samfurin ya yi daidai da na daidaitaccen bayani.
KYAUTA
• Abubuwan da ke cikin Alpha Tocopherol
Mai narkewa: 0.25 ml na phenolphthalein TS a cikin 1 L na barasa
Maganin daidaitaccen ciki: 12 mg / ml na ethyl arachidate a cikin isooctane
Daidaitaccen bayani: Canja wurin 32.5 MG na USP Alpha Tocopherol RS zuwa flask mai dacewa.Ƙara 2 ml na pyridine da 0.5 ml na N,O-bis (trimethylsilyl) trifluoroacetamide tare da 1% trimethylchlorosilane, da kuma zafi flask a 100 don 10 min.A kwantar da flask ɗin, ƙara 5.0 ml na daidaitaccen bayani na ciki da 20 ml na isooctane, sannan a girgiza.
Maganin samfurin: Canja wurin adadin daidai da 0.100-0.160 g na Vitamin E Polyethylene Glycol Succinate narke a 60 zuwa bututun al'ada (kimanin 20 cm tsayi da 2.5 cm a diamita) sanye da hular dunƙule.Ƙara 40-50 MG na ascorbic acid da 'yan tafasasshen kwakwalwan kwamfuta, sannan 20 ml na Solvent ya biyo baya.[Lura — Reflux maganin a hankali ba tare da fitar da abun ciki ba.] Sanya bututu a cikin toshe mai dumama saita a 100-150.Lokacin da samfurin ya narke sosai, ƙara 0.25 g na potassium hydroxide, kuma ci gaba da reflux na minti 30.Cire bututun daga zafi, kuma yayin da abun cikin ke ciki har yanzu yana zafi, ƙara 1-2 ml na hydrochloric acid dropwise har sai launin ruwan hoda ya ɓace.[Tsafe-Tsarki-Aikin Exothermic.Bada acid din ya zube cikin bututun don hana yaduwa.] kwantar da bututu, sa'an nan kuma wanke bangarorin bututu tare da 20 ml na ruwa.Ƙara 5.0 ml na daidaitaccen bayani na ciki, hula, da girgiza don tabbatar da haɗuwa sosai.Bada bututun ya tsaya har sai an samar da yadudduka daban-daban.Canja wurin 2.5-3.5 ml na saman Layer a cikin flask mai dacewa, kuma ƙara 2.0 ml na pyridine sannan 2.5 ml na N, O-bis (trimethylsilyl) trifluoroacetamide tare da 1% trimethylchlorosilane.Gasa flask a 100 don minti 10.Cool, sannan ƙara 12 ml na isooctane.
Tsarin chromatographic
(Duba Chromatography 621, Dacewar Tsarin.)
Yanayin: GC
Mai ganowa: ionization na harshen wuta
Tushen: 0.25-mm × 15-m fused-silica capillary;mai rufi da 0.25-µm fim na lokaci G27
Zazzabi
Saukewa: 280
Mai ganowa: 345
Shafi: Duba Tebur 1.
Tebur 1
Zazzabi na farko (°) Tsawon zafin jiki (°/min) Zazzabi na ƙarshe (°) Riƙe Lokacin a Zazzabi na Ƙarshe (min)
260 20 340 1
Gas mai ɗaukar nauyi: Helium
Yawan gudu: 1.5 ml/min
Girman allura: 1 µL
Nau'in allura: Raba rabo, 200:1
Dacewar tsarin
Misali: Daidaitaccen bayani
Abubuwan da suka dace
Matsayin wutsiya: NMT 2.0 don kololuwar alpha tocopherol
Matsakaicin ma'auni na dangi: NMT 2.0% don rabon yankin kololuwar alpha tocopherol zuwa daidaitaccen yanki na ciki.
Bincike
Samfurori: Daidaitaccen Magani da Samfurin Magani
Yi lissafin adadin d-alpha tocopherol (C29H50O2) a cikin ɓangaren Vitamin E Polyethylene Glycol Succinate da aka ɗauka:
Sakamako = (RU/RS) × (WS/WU) × 100
RU = daidaitattun daidaitattun ciki (yankin kololuwar alpha tocopherol / yanki mafi girma na daidaitaccen ciki) daga samfurin samfurin
RS= daidaitaccen rabo na ciki (yankin kololuwar alpha tocopherol/yankin kololuwar ma'aunin ciki) daga daidaitaccen bayani
WS = nauyin USP Alpha Tocopherol RS da aka yi amfani da shi don shirya daidaitaccen bayani (mg)
WU = nauyin Vitamin E Polyethylene Glycol Succinate da aka ɗauka don shirya Maganin Samfurin (mg)
Sharuɗɗan karɓa: NLT 25.0%
MAKAMMAN JARRABAWA
• Juyawar gani, Takamaiman Juyawa 781S
[Lura-Wannan gwajin yana gano d-alpha tocopherol bayan saponification.]
Maganin samfurin: Canja wurin 0.9 g na Vitamin E Polyethylene Glycol Succinate, narkar da shi a 60, zuwa bututun gwaji mai dacewa wanda aka saka da hula, kuma a narke cikin 10.0 ml na barasa.Sanya bututun a cikin katangar dumama saita a 100-105.[Note-Reflux maganin a hankali ba tare da fitar da abun ciki ba.] Lokacin da samfurin ya narke sosai, ƙara 2-3 pellets na sodium hydroxide, kuma ci gaba da reflux don ƙarin 30 min.Cire bututun daga zafi, kuma yayin da abun ciki har yanzu yana zafi, kawar da shi ta amfani da phenolphthalein a matsayin mai nuna alama ta hanyar ƙara 10 ml na cakuda ruwa da hydrochloric acid (1: 1) har sai launin ruwan hoda ya ɓace.[Tsafe-Tsarki-Aikin Exothermic.Bada maganin acid ɗin ya zube cikin bututu don hana yaɗuwa.Ƙara 25.0 ml na heptane, hula, da girgiza don 1 min don tabbatar da haɗuwa sosai.Bada bututun ya tsaya har sai an samar da yadudduka daban-daban.Canja wurin saman saman zuwa busasshiyar al'ada mai tsabta, sannan ƙara 10.0 ml na ruwa zuwa maganin da aka gano.Mafa, girgiza, kuma ba da damar yadudduka su rabu.Canja wurin babban Layer zuwa bututu mai tsabta, bushe.Ƙara 10.0 ml na potassium ferricyanide bayani, shirya ta hanyar narkar da 2 g na potassium ferricyanide a cikin 10.0 ml na 0.2 M sodium hydroxide, kuma maye gurbin hula.Girgiza da ƙarfi don 45 s, kuma ba da damar yadudduka su rabu na minti 30.Idan saman heptane Layer ya bayyana, ci gaba da ma'auni don takamaiman juyawa;idan ba a bayyana ba, bushe sama da sodium sulfate mai anhydrous kafin a ci gaba da gwajin.[Lura-Yi amfani da sakamakon gwajin don Abubuwan da ke cikin Alpha Tocopherol don ƙididdige takamaiman juyawa.]
Sharuɗɗan karɓa: NLT +24.0
• Solubility a cikin Ruwa
Misali: 20 g na narke Vitamin E Polyethylene Glycol Succinate
Nazari: Sanya Samfurin a cikin akwati na gilashi akan abin motsa jiki.Nan da nan ƙara 80 ml na ruwan zãfi yayin motsawa.Bada damar kwantar da zafin jiki tare da motsawa akai-akai.
Sharuɗɗan karɓa: Maganin ya bayyana a cikin sa'o'i 3.
• Darajar Acid
Misali: 1 g na Vitamin E Polyethylene Glycol Succinate
Nazarin: Narkar da Samfurin a cikin 25 ml na cakuda barasa da ether (1: 1) wanda aka lalata zuwa phenolphthalein tare da 0.1 N sodium hydroxide.Ƙara 0.5 ml na phenolphthalein TS, kuma titrate tare da 0.10 N sodium hydroxide har sai maganin ya kasance mai laushi da ruwan hoda bayan girgiza na 30s.
Sharuɗɗan karɓa: NMT 0.027 mEq/g, daidai da NMT 0.27 mL na 0.10 N sodium hydroxide
KARIN BUKATA
• Marufi da Ajiya: Ajiye a cikin matsuguni, da adana kariya daga haske.
• Lakabi: Lakabin yana nuna abun ciki na d-alpha tocopherol, wanda aka bayyana a cikin mg/g.
• Matsayin Magana na USP 11
USP Alpha Tocopherol RS

Amfani:

Isasshen Ƙarfin: isassun wurare da masu fasaha

Sabis na Ƙwararru: Sabis na siyan tasha ɗaya

Kunshin OEM: Kunshin al'ada da alamar akwai

Bayarwa da sauri: Idan yana cikin haja, garantin isar da kwanaki uku

Ƙarfin Ƙarfi: Kula da haja mai ma'ana

Taimakon Fasaha: Akwai maganin fasaha

Sabis na Haɗa na Musamman: Ya bambanta daga gram zuwa kilos

High Quality: An kafa cikakken tsarin tabbatar da inganci

FAQ:

Yadda ake siya?Da fatan za a tuntuɓiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

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9002-96-4 -Aikace-aikace:

Vitamin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) samfurin roba ne.Akwai shi azaman mara-fari zuwa kodadde rawaya waxy Solid kuma a zahiri bashi da ɗanɗano.A zahiri, cakuda ne wanda aka haɗa musamman na polyethylene glycol 1000 monoesterified, da polyethylene glycol 1000 diesterified, polyethylene glycol 1000 kyauta, da tocopherol kyauta.
Vitamin E Polyethylene Glycol Succinate an yi amfani da ko'ina a cikin Pharmaceutical bincike, a matsayin mai solubilizer, sha ciyarwa, emulsifier, plasticizer da m na ruwa-insoluble ko mai soluble magani tsarin bayarwa, kamar m watsawa, m ga ido miyagun ƙwayoyi isar, m ga intranasal. isar da magunguna, da dai sauransu A matsayin kayan abinci.
Vitamin E Polyethylene Glycol Succinate shine tushen ruwa mai narkewa na bitamin E, an samo shi ta hanyar amsa ƙungiyar carboxyl na bitamin E succinate tare da ƙungiyar hydroxyl na polyethylene glycol.Domin ya ƙunshi duka biyu bitamin E lipophilic kungiyar da polyethylene glycol hydrophilic dogon sarkar, yana da kyau surfactant Properties da ruwa solubility, wanda zai iya muhimmanci ƙara sha na insoluble kwayoyi a cikin gastrointestinal fili, ya karu bioavailability.
A cikin 'yan shekarun nan, yawancin binciken sun gano cewa TPGS ba kawai za a iya amfani da su azaman magungunan magunguna ba, amma har ma yana da halaye na musamman, kamar yadda masu haɓakawa da haɓaka juriya da yawa, TPGS kuma za a iya amfani da su ga prodrugs, micelles, liposomes, TPGS-copolymer. dillalai don inganta solubility, permeability da kwanciyar hankali na shirye-shiryen, don cimma jinkirin, sakin sarrafawa da sakamako mai niyya, inganta haɓakar ƙwayoyi.
1. Pharmaceutical - Vitamin E-TPGS ƙwarai inganta sha, bioavailability da tasiri na Pharmaceutical sinadaran (APIs)
2. Abincin abinci - Ana amfani da Vitamin E-TPGS don samar da kari, musamman waɗanda aka ƙirƙira don inganta labsorption na bitamin E da sauran abubuwan gina jiki na lipophilic da na gina jiki.
3. Abinci da Abin sha - Ana iya amfani da Vitamin E-TPGS don ƙarfafa abinci da abin sha, abubuwan sha na wasanni, ruwa da ruwan 'ya'yan itace.
4. Keɓaɓɓen Kulawa - Vitamin E-TPGS yana aiki azaman ethanol kyauta, hypoallergenic, emulsifier mara fushi / mai haɓakawa a cikin kulawar sirri da aikace-aikacen kwaskwarima.
5. Kayayyakin Gina Jiki na Dabbobi - Vitamin E-TPGS yana ba da bitamin E mai sauƙin ɗauka da rayuwa ga dabbobi waɗanda ba sa ɗaukar nau'ikan bitamin E na gargajiya yadda ya kamata.

9002-96-4 -Aikace-aikacen Magunguna:

Vitamin E polyethylene glycol succinate wani esterified bitamin E (tocopherol) samu da farko amfani da matsayin solubilizer ko emulsifying wakili saboda surfactant Properties.A tsarin, shi ne amphipathic da hydrophilic, sabanin tocopherols, sabili da haka yana da wani ruwa mai narkewa wanda za a iya amfani da su a cikin pharmaceutical formulations kamar capsules, Allunan, zafi-narke extrusion, microemulsions, Topical kayayyakin, da parenterals.Ɗaya daga cikin mafi mahimmanci aikace-aikace shine amfani da shi azaman abin hawa don tsarin isar da magunguna na tushen lipid.Hakanan za'a iya amfani dashi azaman tushen bitamin E. Vitamin E polyethylene glycol succinate an kwatanta shi da tsarin aikin sa kuma yayi karatu azaman mai hana Pglycoprotein.

9002-96-4 - Rashin daidaituwa:

Vitamin E polyethylene glycol succinate bai dace da acid mai ƙarfi da alkalis mai ƙarfi ba.

9002-96-4 - Matsayin Gudanarwa:

GRAS da aka jera.Kunshe a cikin Database Database Ingredients marasa aiki (maganin ophthalmic ko saukad da; capsules na baka, bayani, kwamfutar hannu; Maganin Topical ko digo).Kunshe a cikin Lissafin Kanadiya na Karɓar Sinadaran marasa magani.

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