Zoledronic Acid CAS 118072-93-8 Tsafta ≥99.7% API Babban Inganci

Zoledronic Acid (CAS 118072-93-8) wani m bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50=20 nM).Yana hana haɓakar kashi na osteoclast.Hakanan yana hana siginar Ras da haɓakar ƙari, kuma yana haifar da apoptosis a cikin ƙwayoyin kansa na pancreatic.Yana juya canjin epithelial-mesenchymal kuma yana hana sabuntawar ƙwayar nono ta hanyar rashin kunna NF-κB.Zoledronic acid ya sami amincewa da FDA ta Amurka a cikin 2001 don maganin hypercalcemia na malignancy, rikitarwa na rayuwa wanda zai iya zama barazanar rai.Hypercalcemia na malignancy na iya faruwa a cikin kusan 50% na marasa lafiya da aka gano suna da ci-gaban ciwon nono, myeloma da yawa, da ciwon huhu na huhu mara ƙanƙara.Wannan yanayin yana tasowa ne lokacin da ƙwayoyin sinadarai da ƙari ke haifar da haɓakar osteoclasts.Lokacin da aka sami karuwa a cikin lalata kashi, ana samun sakin calcium a lokaci guda a cikin plasma.Lokacin da adadin ƙwayoyin calcium na jini ya ƙaru da sauri, kodan ba su iya ɗaukar nauyin nauyi, kuma sakamakon hypercalcemia.Zoledronic acid yana rage yawan adadin calcium na plasma yadda ya kamata ta hanyar hana haɓakar kashi (hana ayyukan osteoclastic da shigar da osteoclast apoptosis).Bugu da ƙari, an amince da acid ɗin zoledronic daga FDA ta Amurka don maganin myeloma da yawa da ƙasusuwan kashi masu alaƙa da ƙaƙƙarfan cututtukan daji masu tushen ƙari (misali, sujada da huhu).