2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 Maʻemaʻe ≥98.0% Olaparib Intermediate Factory
Maʻemaʻe Kiʻekiʻe, Hana Kūʻai
ʻO Olaparib a me nā mea pili e pili ana:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)ʻakika benzoic CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Inoa Kimia | 2-Fluoro-5-Formylbenzonitrile |
| Nā huaʻōlelo like | 3-Cyano-4-Fluorobenzaldehyde |
| Helu CAS | 218301-22-5 |
| Helu CAT | RF-PI451 |
| Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona |
| ʻĀpana Molekala | C8H4FNO |
| Kaumaha Molecular | 149.12 |
| Lae hehee | 80.0 a i 84.0 ℃ (māmā) |
| Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka Methanol |
| Brand | ʻO Ruifu Chemical |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Melemele i ka pauda keʻokeʻo |
| Maemae | ≥98.0% |
| Māmā (KF) | ≤0.50% |
| Huina paumaele | ≤2.0% |
| Kūlana hoʻāʻo | ʻOihana Kūlana |
| Hoʻohana | Ka waena o Olaparib (CAS: 763113-22-0) PARP-Inhibitor |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.
Hoʻohana ʻia ʻo 2-Fluoro-5-Formylbenzonitrile (CAS: 218301-22-5) i ka hoʻomākaukau ʻana i nā pūhui heterocyclic e like me nā mea paʻa PARP no ka hoʻohana lāʻau.Hoʻohana ʻia ʻo 2-Fluoro-5-Formylbenzonitrile ma ke ʻano he waena o Olaparib (CAS: 763113-22-0).ʻO Olaparib kahi mea hoʻopale mole liʻiliʻi o PARP1/PARP2 (IC50: 5/1 nM) akā ʻoi aku ka maikaʻi ma mua o ka PARP tankyrase-1 (IC50: 1.5 µM).ʻO Olaparib (AZD-2281, inoa kālepa ʻo Lynparza) he lāʻau lapaʻau i ʻāpono ʻia e FDA no ka maʻi kanesa, i hoʻomohala ʻia e KuDOS Pharmaceuticals a ma hope e AstraZeneca.He mea hoʻopale PARP ia, e kāohi ana i ka poly ADP ribose polymerase (PARP), he enzyme i komo i ka hoʻoponopono DNA. He hana ia e kūʻē i nā maʻi maʻi maʻi i loko o ka poʻe me ka hoʻololi BRCA1 a BRCA2 hoʻoilina, aia kekahi mau maʻi maʻi ovarian, umauma, a me ka prostate.I Kekemapa 2014, ua ʻae ʻia ʻo olaparib no ka hoʻohana ʻana ma ke ʻano he mea hoʻokahi e ka EMA a me ka FDA.Aia ka ʻae ʻana o FDA no ka germline BRCA mutated (gBRCAm) advanced ovarian cancer i loaʻa i ʻekolu a ʻoi aʻe mau laina o ka chemotherapy.
