4-Amino-3-Chlorophenol CAS 17609-80-2 Lenvatinib Mesylate Ma'ema'e Waena >99.0% (HPLC)

ʻO 4-Amino-3-Chlorophenol (CAS: 17609-80-2) he mea koʻikoʻi ka lāʻau lapaʻau koʻikoʻi, i hoʻohana nui ʻia i ka hoʻolālā a me ka synthesis o nā anti-tumor, nā maʻi cardiovascular, nā maʻi maʻi neurological.ʻO 4-Amino-3-Chlorophenol kahi mea koʻikoʻi waena i ka hoʻomākaukau ʻana o Lenvatinib Mesylate (CAS: 857890-39-2).Hoʻomohala ʻia e Eisai Inc., ʻo lenvatinib mesylate he mea hoʻokae endothelial growth factor receptor (VEGF) i loaʻa ka hana e kūʻē i nā subtypes VEGF 1, 2, a me 3 a ua ʻae ʻia e ka FDA ma 2015 no ka mālama ʻana i ka maʻi maʻi thyroid like ʻole. hou, metastatic, a holomua paha a ʻaʻole i pane i ka lāʻau iodine radioactive.I Mei 2016, ua ʻae ka FDA i ka lāʻau lapaʻau ma ke ʻano he hui hui me everolimus no ka mālama ʻana i ka maʻi maʻi maʻi renal cell carcinoma.No ka mea, ua manaʻo ʻia ʻo VEGF (a me ka fibroblast growth factor receptors, i kapa ʻia ʻo FGFRs) i ke kuleana i nā ala hōʻailona cardiovascular, ua manaʻo ʻia ʻo VEGF2R a me FGFR inhibition nā mea hana ma hope o ka hopena mua o ka lenvatinib mesylate, ʻo ia ka hypertension.