4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Maʻemaʻe >99.0% (HPLC) Aprepitant Intermediate Factory
Mea hana alakaʻi a mea hoʻolako
Nā Kūwaena o Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Inoa Kimia | 4-Benzyl-2-Hydroxymorpholin-3-kahi |
| Nā huaʻōlelo like | 4-Benzyl-2-Hydroxy-Morpholin-3-hoʻokahi;2-Hydroxy-4-(Phenylmethyl)-3-Morpholinone;Aprepitant Impurity 48;Fosaprepitant haumia 23;Aprepitant Intermediate Ⅱ |
| Helu CAS | 287930-73-8 |
| Helu CAT | RF2660 |
| Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
| ʻĀpana Molekala | C11H13NO3 |
| Kaumaha Molecular | 207.23 |
| Lae hehee | 134.0 a 138.0 ℃ |
| Lae paila | 441.7±45.0℃ |
| ʻO ka mānoanoa | 1.292±0.06 g/cm3 |
| Solubility i ka wai | DMSO (Lili iki), Methanol (Lili'ili, Wela) |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo a i ka pauka kristal keʻokeʻo |
| Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) |
| Lae hehee | 134.0 a 138.0 ℃ |
| Wai (na Karl Fischer) | <0.50% |
| Koena ma ka Ignition | <0.20% |
| Huina paumaele | <1.00% |
| Proton NMR Spectrum | Kūlike i ka hoʻolālā |
| Kūlana hoʻāʻo | Kūlana ʻoihana |
| Hoʻohana | Waena o Aprepitant (CAS: 170729-80-3) Laau Laau Antiemetic |
Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai
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ʻO 4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), he mea waena o Aprepitant (CAS: 170729-80-3), i hoʻohana ʻia e like me nā lāʻau antiemetic.ʻO Aprepitant kahi mea kū'ē kū'ē neurokinin-1 (NK-1) a no nā mea lapaʻau o ka luaʻi i ka wā o ka chemotherapy o ka maʻi kanesa.Ua hoʻomohala mua ʻia e Merck Company (German).I Malaki 2003, ua ʻae ka US Food and Drug Administration no ka hoʻohana ʻana i ka mālama ʻana i ka luaʻi chemotherapy.Loaʻa i kēia huahana kahi pilina koho kiʻekiʻe i ke kanaka a he haʻahaʻa haʻahaʻa i ka serotonin, dopamine a me ka glucocorticoid receptor affinity.Aprepitant, ke hui pū me 5-HT3 receptor inhibitors (e like me ka ondansetron hydrochloride) a me ka corticosteroid dexamethasone, hiki ke hoʻohaʻahaʻa hou i ka cisplatin-induced acute a (a) hoʻopaneʻe emesis.ʻO ka hoʻohana wale ʻana i kēia lāʻau lapaʻau hiki ke loaʻa kekahi hopena pale.
![(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2 Maʻemaʻe >99.0% (GC) Aprepitant Intermediate](https://www.ruifuchemical.com/uploads/R-1-35-Bistrifluoromethylphenylethanol-CAS-127852-28-2-300x300.jpg)