Olaparib Intermediate CAS 763114-26-7 Maʻemaʻe ≥98.5% Hale Hana
Maʻemaʻe Kiʻekiʻe, Hana Kūʻai
ʻO Olaparib a me nā mea pili e pili ana:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)ʻakika benzoic CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Inoa Kimia | 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)ʻakika benzoic |
| Nā huaʻōlelo like | 2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]ʻakika benzoic |
| Helu CAS | 763114-26-7 |
| Helu CAT | RF-PI450 |
| Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona |
| ʻĀpana Molekala | C16H11FN2O3 |
| Kaumaha Molecular | 298.27 |
| Brand | ʻO Ruifu Chemical |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Melemele i ka pauda keokeo |
| Hoʻāʻo | ≥98.5% |
| Māmā (KF) | ≤0.50% |
| Huina paumaele | ≤1.5% |
| Kūlana hoʻāʻo | ʻOihana Kūlana |
| Hoʻohana | Kūwaena o Olaparib (CAS: 763113-22-0) |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, pahu pahu pahu, 25kg / pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.
ʻO 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid (CAS: 763114-26-7) kahi mea waena i hoʻohana ʻia i ka synthesis o Olaparib (CAS: 763113-22 -0).ʻO Olaparib, i kūʻai ʻia e AstraZeneca ma lalo o ka inoa inoa ʻo Lynparza, ua ʻae ʻia i ka USA i Dekemaba 2014 ma ke ʻano he lāʻau lapaʻau, hoʻokahi-agent therapy no ka mālama ʻana i ka germline BRCA-mediated advanced ovarian cancer.Olaparib, i hoʻokumu mua ʻia e KuDOS pharmaceuticals a ma hope mai e AstraZeneca , hana ma ke ʻano he poly ADP ribose polymerase inhibitor a ua ʻae ʻia no nā poʻe maʻi i loaʻa i ʻekolu a ʻoi aʻe nā lāʻau lapaʻau o ka chemotherapy.I nā hoʻokolohua lapaʻau, ua hoʻolōʻihi ka lāʻau i ke ola holomua holomua no nā poʻe maʻi e loaʻa ana i ka platinum-sensitive recurrent serous ovarian cancer.Aia ʻo Olaparib i kēia manawa i nā ʻāpana like ʻole o ka hoʻokolokolo ʻana no ka mālama ʻana i ka umauma, ka ʻōpū, ka prostate, ka pancreatic a me ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi.
