5-Fluorocytosine (5-FC) CAS 2022-85-7 Maʻemaʻe ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Ke Ana Hana
ʻAno-keʻokeʻo a ʻaneʻane keʻokeʻo ka pauka kristal
Pohō ma ka hoʻomaloʻo-hoʻomaloʻo iā ia ma 105 no 4 mau hola: ʻaʻole e nalowale ma mua o 1.50% o kona kaumaha.
Ke koena ma ka Ignition-ʻaʻole iʻoi aku ma mua o 0.1%.
Nā metala kaumaha-ʻaʻole iʻoi aku ma mua o 0.002%.
Fluoride-Mix 70 mL o ka mea hou i hoomakaukauia saturated potassium chloride solution me 30 mL o ka isopropyl alcohol, e hoopiha i ka electrode me ka supernatant akaka, a e ae i ka electrode e noho i loko o ka hui no ka emi ole ma mua o 2 hola ma mua o ka hoʻohana 'ana, ai ole ia i ka pō.
I ka lawe ʻana i nā ana, e hoʻololi i ka hoʻonā i kahi beaker 150-mL, a e hoʻokomo i nā electrodes.E hoʻokomo i ka pahu hoʻoulu ʻia i uhi ʻia i polytef i loko o ka beaker, e kau i ka beaker ma luna o ka mea hoʻoheheʻe magnetic me ka uhi ʻia o luna, a e hoʻokuʻu a hiki i ka loaʻa ʻana o ke kaulike (ma kahi o 1 a 2 mau minuke).Holoi a hoʻomaloʻo i nā electrodes ma waena o nā ana, e mālama pono i ʻole e ʻoki i ke aniani i loko o ka electrode ion kikoʻī.
E ana i ka hiki o kēlā me kēia hoʻomākaukau maʻamau, a e hoʻolālā i ka ʻike fluoride, ma ka mg no 100 mL, me ka hiki, ma ka mV, ma ka pepa semilogarithmic.E ana i ka hiki o ka hoomakaukau Ho'āʻo, a e hoʻoholo mai ka pihi maʻamau i ka ʻike fluoride, ma ka mg no 100 mL.E helu i ka pākēneka o ka fluoride i loko o ka māhele o Flucytosine i lawe ʻia e ke kumu:
C / 10
i loko o ka C ka mana'o o ka fluoride, ma ka mg no 100 mL, mai ka piko ma'amau: 'a'ole i oi aku ma mua o 0.05% o ka fluoride.
Fluorouracil-Dissolve 250 mg i 10 mL o ka hui ʻana o ka waikawa acetic glacial a me ka wai (4:1).E hoʻopili i 20 µL o kēia hoʻonā i kahi pā chromatographic ʻāpana lahilahi i uhi ʻia me kahi ʻāpana 0.5-mm o ka hui ʻana o ka chromatographic silica gel.Ma ka pā like e hoʻopili i 20 µL, i nā hoʻonui 10-µL, o kahi solution 0.025 mg no ka mL o USP Fluorouracil RS i loko o ka hui ʻana o ka waikawa acetic glacial a me ka wai (4:1).E hoʻomohala i ka chromatogram i loko o ka hui ʻana o ka chloroform a me ka glacial acetic acid (13:7) a hiki i ka neʻe ʻana o ka mea hoʻoheheʻe mua ma lalo o 14 knm mai ke kumu.Wehe i ka pā mai ke keʻena e ulu ana, a ʻae i ka mea hoʻoheheʻe e mahu.E ʻimi i nā kiko ma ka pā ma ka nānā ʻana ma lalo o ka radiation UV pōkole-lōʻihi: ʻaʻole ʻoi aku ka nui a me ka ikaika o kēlā me kēia wahi mai ka hopena i lalo o ka hoʻāʻo ʻana ma mua o ka wahi ma kēlā me kēia RF i hana ʻia e ka solution Standard, ʻaʻole i ʻoi aku ma mua o 0.1% o fluorouracil.
Assay-Place ma kahi o 400 mg o Flucytosine, i kaupaona pono, i loko o ka beaker 250-mL, e hoʻohui i 150 mL o ka hui ʻana o 2 mau puke o ka ʻakika glacial acetic a me 1 ka nui o ka acetic anhydride, a hoʻoheheʻe, hoʻomehana mālie inā pono.Titrate potentiometrically me 0.1 N perchloric acid VS, me ka hoohana ana i ka calomel-glass electrode system.Hana i kahi hoʻoholo hakahaka, a hana i nā hoʻoponopono e pono ai.Ua like kēlā me kēia mL o 0.1 N perchloric acid me 12.91 mg o C4H4FN3O.ʻAʻole i emi iho ka Flucytosine ma lalo o 98.5 pākēneka a ʻaʻole ʻoi aku ma mua o 101.0 pākēneka o C4H4FN3O, i helu ʻia ma ke kumu maloʻo.