6-O-Methylguanine CAS 20535-83-5 Hale Hana Kūwaena Nelzarabine
Hoʻolako me ka hoʻomaʻemaʻe kiʻekiʻe, ka hana kalepa
Inoa Kemika: 6-O-Methylguanine
CAS: 20535-83-5
| Inoa Kimia | 6-O-Methylguanine |
| Nā huaʻōlelo like | 2-Amino-6-Methoxypurine |
| Helu CAS | 20535-83-5 |
| Helu CAT | RF-PI509 |
| Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona |
| ʻĀpana Molekala | C6H7N5O |
| Kaumaha Molecular | 165.16 |
| Lae hehee | >300 ℃ (māmā) |
| Brand | ʻO Ruifu Chemical |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Pauda Crystalline Keʻokeʻo |
| Hana ʻIke / ʻIke | ≥98.5% (HPLC) |
| Nalo ma ka maloo | ≤0.50% |
| Koena ma ka Ignition | ≤0.50% |
| Huina paumaele | ≤1.5% |
| Kūlana hoʻāʻo | ʻOihana Kūlana |
| Hoʻohana | Kūwaena o Nelzarabine (CAS: 121032-29-9), T-ALL & T-LBL |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.
Hiki ke hoʻohana ʻia ka 6-O-Methylguanine (CAS: 20535-83-5) ma ke ʻano he waena i ka synthesis o Nelzarabine (CAS: 121032-29-9).ʻO ka Nelarabine kahi prodrug no ka deoxyguanosine analogue-9-beta-D-arabinofuranosyl guanine (ara-G).Nelarabine demethylates i ke kuleana o adenosine deaminase (ADA) a lilo i ara-G.Ua hoʻomohala mua ʻia ʻo Nelarabine e GlaxoSmithKline.Ma ʻOkakopa 28, 2005 ma lalo o ka ʻae ʻia e ka US Food and Drug Administration, ua lilo ia i lāʻau lapaʻau hou no ka ho'ōla ʻana i ka maʻi maʻi T-cell acute lymphoblastic leukemia (T-ALL) a me T-Cells lymphoblasticlymphoma (T-LBL) i kū i ka liʻiliʻi. ʻelua ʻano o ka chemotherapy regimens a i ʻole hoʻi hou ma hope o ka mālama mua ʻana.Ua hoʻopaʻa inoa ʻia kēia lāʻau lapaʻau hou ma United States i ka makahiki 2006.
