7-Fluoro-6-Nitroquinazolin-4(1H)-hoʻokahi CAS 162012-69-3 Maʻemaʻe >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

ʻO ka wehewehe pōkole:

Inoa Kemika: 7-Fluoro-6-Nitroquinazolin-4(1H)-one

CAS: 162012-69-3

Maʻemaʻe: >99.0% (HPLC)

Melemele a ʻulaʻula Melemele Crystal a pauda paha

Waena o Afatinib Dimaleate (CAS: 850140-73-7)

ʻO ke kūlana kiʻekiʻe, ka hana kālepa

E-Mail: alvin@ruifuchem.com

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

ʻO Ruifu Nā Kūwaena Hoʻolako Kimia o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-hoʻokahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy)quinazolin-4-AmineCAS 314771-88-5

Na Waiwai Kemika:

Inoa Kimia	7-Fluoro-6-Nitroquinazolin-4(1H)-hoʻokahi
Nā huaʻōlelo like	7-Fluoro-6-Nitroquinazolin-4(3H)-hoʻokahi;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-one
Helu CAS	162012-69-3
Helu CAT	RF-PI2025
Kūlana Kūʻai	Ma ka waihona, hoʻonui ʻia a hiki i nā tona
ʻĀpana Molekala	C8H4FN3O3
Kaumaha Molecular	209.13
Brand	Kemika Ruifu

Nā kikoʻī:

'ikamu	Nā kikoʻī
Ka nana aku	Melemele a ʻulaʻula Melemele Crystal a pauda paha
1 H NMR Spectrum	Kūlike me ka hoʻolālā
Maʻemaʻe / Kaʻina Hanana	>99.0% (HPLC)
Nalo ma ka maloo	<0.50%
Huina paumaele	<1.00%
Proton NMR Spectrum	Kūlike i ka hoʻolālā
Kūlana hoʻāʻo	Kūlana ʻoihana
Hoʻohana	Waena o Afatinib Dimaleate (CAS: 850140-73-7)

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai

Pono:

FAQ:

Noi:

ʻO 7-Fluoro-6-Nitroquinazolin-4(1H)-one (CAS: 162012-69-3) he mea waena o Afatinib Dimaleate (CAS: 850140-73-7).He ʻohana ErbB hiki ʻole ke hoʻohuli ʻia ʻo Afatinib e kāohi i ka hoʻouna ʻana i ka ʻike a pale i nā ala nui e pili ana i ka ulu ʻana o ka maʻi kanesa a me ka mahele.No ka mea hiki ke hoʻoulu ʻia ka mīkini unuhi ʻike ʻohana ErbB e nā homodimers a me nā heterodimers, hiki ke hoʻopau i ka lawe ʻana i ka ʻike ma lalo o ka ʻohana ErbB (e like me EGFR, HER2, ErbB3 a me ErbB4).ʻO Afatinib kahi lāʻau lapaʻau i ʻae ʻia no ka mālama ʻana i ka maʻi maʻi maʻi ʻaʻole liʻiliʻi liʻiliʻi (NSCLC), i hoʻomohala ʻia e Boehringer Ingelheim.Hana ia ma ke ʻano he angiokinase inhibitor.E like me ka lapatinib a me ka neratinib, ʻo ka afatinib he tyrosine kinase inhibitor (TKI) i hoʻopaʻa ʻole i ke kanaka epidermal growth factor receptor 2 (Her2) a me ka epidermal growth factor receptor (EGFR) kinases.ʻAʻole ikaika wale ʻo Afatinib e kūʻē i nā mutations EGFR i manaʻo ʻia e nā hanauna mua TKI likeerlotinib a i ʻole gefitinib, akā kūʻē pū kekahi i ka poʻe ʻike ʻole i kēia mau lāʻau lapaʻau maʻamau.Ma muli o kāna hana hou aku e kūʻē iā Her2, ke noiʻi ʻia nei no ka maʻi maʻi umauma a me nā maʻi maʻi maʻi EGFR a me Her2 ʻē aʻe.