Afatinib CAS 439081-18-2 Maʻemaʻe >99.5% (HPLC) Hale Hana

ʻO Afatinib, ka mea i kapa ʻia ʻo BIW-2992, (CAS: 439081-18-2) ʻo ia ka lua o ka hanauna ikaika a hiki ʻole ke hoʻololi ʻia ʻelua mea hoʻopaneʻe o ka epidermal growth factor receptor (EGFR) a me ke kanaka epidermal growth factor receptor 2 (HER2) tyrosine kinase, hoʻomohala ʻia e Boehringer Ingelheim, Kelemānia.Hiki iā ia ke pale i ka hana o ka tyrosine kinase ma ke komo ʻana i ka hopena Michael me ka hui thiol o ka cysteine ​​​​ma ke kūlana 797 o ka EGFR.Ma Iulai 12, 2013, ua lilo ia i lāʻau hou no ka anti-small cell lung cancer i ʻae ʻia e ka US FDA ma lalo o ka inoa kālepa ʻo Gilotrif.He papa keia laau.Hoʻohana ʻia ia no ka mālama ʻana i nā maʻi i loaʻa i ka metastatic non-small cell lung cancer (NSCLC) me ka nalowale o ka 19th exon a i ʻole L858R mutation i ka 21th exon o ka tumor epidermal growth factor receptor (EGFR) i hōʻoia ʻia me ka hoʻohana ʻana i ka pahu i ʻae ʻia. na FDA.He kūpono hoʻi ka lāʻau lapaʻau i ka mālama ʻana i nā maʻi maʻi HER2-maikaʻi me ka maʻi maʻi umauma kiʻekiʻe.Aia ʻo Afatinib i kahi papa o nā lāʻau i kapa ʻia ʻo tyrosine kinase inhibitors.Hoʻolālā ʻia nā mea hoʻopaneʻe Tyrosine kinase e ālai i ka hana o kahi enzyme kikoʻī i kapa ʻia ʻo tyrosine kinase.He kuleana nui kēia enzyme i ka hana o nā pūnaewele, a he ikaika i ka hoʻoikaika ʻana i ka ulu a me ka holomua.Hana ʻo Afatinib e kāohi i ka hana o ʻelua ʻano tyrosine kinases: epidermal growth factor receptor (EGFR) a me Her2, i "hoʻonui ʻia" e nā ʻano maʻi kanesa.Ma ka pale ʻana i ka hana o kēia mau tyrosine kinases, hiki i ka Afatinib ke pale aku i nā maʻi maʻi mai ka māhele ʻana a me ka ulu ʻana.