Afatinib Dimaleate CAS 850140-73-7 Maʻemaʻe >99.5% (HPLC) API

ʻO Afatinib Dimaleate (CAS: 850140-73-7), ʻo ke ʻano paʻakai dimaleate o afanitib, he mea hana antineoplastic i loaʻa i ka waha.ʻO Afatinib Dimaleate kahi mea hoʻopaneʻe ʻohana EGFR hiki ʻole ke hoʻololi ʻia me IC50s o 0.5 nM, 0.4 nM, 10 nM a me 14 nM no EGFRwt, EGFRL858R, EGFRL858R/T790M a me HER2.Hōʻike ʻia ʻo Afatinib Dimaleate no ka lāʻau lapaʻau mua o nā poʻe maʻi me ka metastatic non-small cell lung cancer (NSCLC) nona nā maʻi koko i loaʻa i ka epidermal growth factor receptor (EGFR) exon 19 deletions a i ʻole exon 21 (L858R) nā hoʻololi hoʻololi e like me ka ʻike ʻia e kahi FDA- hōʻoia ʻae ʻia.I ka wā ma mua, ua manaʻo ʻia ka lāʻau lapaʻau maʻamau me ka platinum-based chemotherapy doublet regimen maʻamau no nā maʻi āpau me NSCLC.Eia nō naʻe, ua ʻike ʻia nā hōʻike e puka mai nei i nā subpopulations kahi e ʻoi aku ka maikaʻi o ka lāʻau lapaʻau i manaʻo ʻia, e alakaʻi ana i ka hoʻomohala ʻana i nā lāʻau lapaʻau.Ua hoʻomohala ʻia ʻo Afatinib Dimaleate e Boehringer Ingelheim Pharmaceuticals, ua ʻae ʻia ʻo Afatinib Dimaleate e ka FDA ma 2013 ma ke ʻano he lāʻau makua ʻole ma lalo o ka inoa kālepa Gilotrif.Hoʻopili ʻia ʻo Afatinib Dimaleate me ka hoʻohana ʻana i nā ʻano maʻamau.Afatinib DimaleateʻAʻole wale ʻo ia e kūʻē i nā mutations EGFR i manaʻo ʻia e nā TKI o ka hanauna mua e like me erlotinib a i ʻole gefitinib, akā kūʻē pū kekahi i nā hoʻololi e like me T790M ʻaʻole pili i kēia mau lāʻau lapaʻau maʻamau.Ma muli o kāna hana hou aku e kūʻē iā Her2, ke noiʻi ʻia nei no ka maʻi maʻi umauma a me nā maʻi maʻi maʻi EGFR a me Her2 ʻē aʻe.