Afatinib Dimaleate Intermediate CAS 314771-76-1 Maʻemaʻe >99.0% (HPLC) Kiʻi Hōʻike ʻia o ka Hale Hana

Afatinib Dimaleate Intermediate CAS 314771-76-1 Maʻemaʻe >99.0% (HPLC) Hale Hana

ʻO ka wehewehe pōkole:

Inoa Kemika: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Maʻemaʻe: >99.0% (HPLC)

ʻAno: Melemele māmā i ka pauda melemele

Waena o Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

ʻO Ruifu Nā Kūwaena Hoʻolako Kimia o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-hoʻokahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy)quinazolin-4-AmineCAS 314771-88-5

Na Waiwai Kemika:

Inoa Kimia	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Nā huaʻōlelo like	N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib haumia B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Helu CAS	314771-76-1
Helu CAT	RF-PI2028
Kūlana Kūʻai	Ma ka waihona, ka mana hana 100MT / makahiki
ʻĀpana Molekala	C18H16ClFN4O2
Kaumaha Molecular	374.8
Lae paila	559.0±50.0℃
ʻO ka mānoanoa	1.473±0.060 g/cm3
Brand	Kemika Ruifu

Nā kikoʻī:

'ikamu	Nā kikoʻī
Ka nana aku	Melemele māmā i ka pauda melemele
ʻIkepili	Pono ka Manawa Paʻa o ke Kiʻekiʻe Poʻokela ma HPLC e kūpono i ke kūlana
Maʻemaʻe / Kaʻina Hanana	>99.0% (HPLC)
Nalo ma ka maloo	<0.50%
Koena ma ka Ignition	<0.20%
Hoʻokahi haumia	<0.50%
Huina paumaele	<1.00%
Nā Metala Kaumaha (e like me Pb)	≤20ppm
Kūlana hoʻāʻo	Kūlana ʻoihana
Hoʻohana	Waena o Afatinib Dimaleate (CAS: 850140-73-7)

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai

Pono:

FAQ:

Noi:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) he mea waena o Afatinib Dimaleate (CAS: 850140-73-7).ʻO Afatinib ka lua o ka hanauna ikaika a hiki ʻole ke hoʻololi ʻia i nā mea hoʻopaneʻe ʻelua o ka epidermal growth factor receptor (EGFR) a me ke kanaka epidermal growth factor receptor 2 (HER2) tyrosine kinase, i hoʻomohala ʻia e Boehringer Ingelheim, Kelemānia.Hiki iā ia ke pale i ka hana o ka tyrosine kinase ma ke komo ʻana i ka hopena Michael me ka hui thiol o ka cysteine ma ke kūlana 797 o ka EGFR.Hana: 1. E like me Lapatinib a me Neratinib, ʻo Afatinib he mea hoʻopaneʻe kinase protein i hiki ʻole ke hoʻoneʻe i ke kanaka epidermal growth factor receptor 2 (Her2) a me ka epidermal growth factor receptor (EGFR) kinases.2. ʻAʻole ikaika wale ʻo Afatinib i nā hoʻololi EGFR i manaʻo ʻia e nā TKI o ka hanauna mua e like me erlotinib a i ʻole gefitinib, akā kūʻē pū kekahi i nā hoʻololi e like me T790M ʻaʻole pili i kēia mau lāʻau lapaʻau maʻamau.Ma muli o kāna hana hou aku e kūʻē iā Her2, ke noiʻi ʻia nei no ka maʻi maʻi umauma a me nā maʻi maʻi maʻi EGFR a me Her2 ʻē aʻe.3. He lāʻau lapaʻau ʻo Afatinib no ka lāʻau lapaʻau mua o nā maʻi me nā ʻano metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC).Hana ʻo ia ma ke ʻano he mea hiki ʻole ke hoʻololi i ka covalent inhibitor o ka receptor tyrosine kinases epidermal growth factor receptor (EGFR) a me erbB-2 (HER2).