Apixaban CAS 503612-47-3 Maʻemaʻe ≥99.5% (HPLC)

ʻO Apixaban (CAS: 503612-47-3) he ʻano hou o ka waha Xa factor inhibitor i hoʻomohala pū ʻia e Bristol-Myers Squibb a me Pfizer.ʻO ka inoa kālepa ʻo eratol, he ʻano hou o ka anticoagulant waha.Ma ke kāohi ʻana i kahi mea coagulation koʻikoʻi Xa, hiki i ka apixaban ke pale i ka hana thrombin a me ka thrombosis.Ma ʻApelila 26, 2007, hui pū ʻo Bristol-Myers Squibb me Pfizer e hoʻolaha i ka hui pū ʻana i ka hoʻomohala ʻana i kahi apixaban anticoagulant waha hou nona ka Bristol-Myers Squibb ma ke ʻano he mea hou i ka warfarin.Wahi a ka ʻaelike hui, e uku ʻo Pfizer i kahi uku mua o US $ 0.25 biliona iā Bristol-Myers Squibb e lawe i ka 60% o ka huina hoʻomohala o ka anticoagulant apixaban (e hoʻokō ʻia mai Ianuali 1, 2007), ʻoiai ʻo Bristol-Myers E lawe ʻo Squibb i ke koena 40%, no laila e loaʻa ai ke kuleana e hoʻomohala a kūʻai aku i ka lāʻau.I ka Mei 2011, ʻo apixaban ka mea mua i ʻae i ka pale ʻana i ka thrombosis venous i nā poʻe maʻi makua e hana ana i ka hip a i ʻole ke kuli pani pani ʻana i nā ʻāina 27 EU, Iceland a me Norewai.Ma ka lā 20 o Nowemapa, 2012, ua ʻae ke Komisina ʻEulopa iā Ererto (apixaban) no ka pale ʻana i ka hahau a me ka systemic embolism i nā poʻe maʻi makua me ka non-valvular atrial fibrillation (NVAF) me hoʻokahi a ʻoi aku paha nā mea pilikia.Ma hope mai, ua ʻae ʻo ka Canadian Food and Drug Administration, Iapana, a me ka US FDA iā Ererto?(apixaban) no ka pale ʻana i ka hahau ʻana a me ka systemic embolism i nā poʻe maʻi makua me ka fibrillation atrial non-valvular (NVAF) me hoʻokahi a ʻoi aku paha nā mea pilikia.Ma ʻApelila 12, 2013, ua hoʻolaha ʻia ka lāʻau anticoagulant hou ʻo Eloto (ELIQUIS) (apixaban) i hui pū ʻia e Bristol-Myers Squibb a me Pfizer e hoʻopaʻa inoa ʻia ma Kina.ʻO Ererto kahi mea hoʻopaneʻe oral factor Xa no ka pale ʻana i ka thromboembolism venous (VTE) i nā poʻe maʻi makua e hele ana i ka hip a i ʻole ke kuli.Hāʻawi kāna papa inoa i kahi koho hou palekana a maikaʻi hoʻi no ka anticoagulation lapaʻau ma hope o ke ʻoki orthopedic, a lawe mai i ka nūhou maikaʻi i nā poʻe maʻi Kina e hoʻololi ana i ka hip/knee elective replacement.Ua hōʻoia ʻia nā noiʻi lapaʻau i hoʻohālikelike ʻia me 40mg enoxaparin hoʻokahi i ka lā, 2 mau manawa i ka lā hoʻokele waha o eratol?(apixaban) ʻoi aku ka maikaʻi o ka 2.5mg no ka pale ʻana i ka thromboembolism venous ma hope o ka hoʻololi ʻana i ka ʻūhā a i ʻole ke kuli, ʻaʻole e hoʻonui i ka pilikia o ke koko.Hōʻike ka Figure 1 i nā papa Elotoapixaban i hana ʻia e Bristol-Myers Squibb a me Pfizer.