Baloxavir Marboxil CAS 1985606-14-1 API Hale Hana Kiʻi Kiʻekiʻe

ʻO Baloxavir Marboxil CAS 1985606-14-1 API Hale Hana Kūlana Kiʻekiʻe

ʻO ka wehewehe pōkole:

Inoa Kemika: Baloxavir Marboxil

CAS: 1985606-14-1

Ke 'ano: Pada ke'oke'o i ka pauka ke'oke'o

ʻIke: 98.0%~102.0%

I ka mālama ʻana i nā maʻi maʻi influenza A a me nā maʻi maʻi influenza B

Hoʻokaʻaʻike: Kauka Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Baloxavir Marboxil (CAS: 1985606-14-1) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku iā Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Na Waiwai Kemika:

Inoa Kimia	ʻO Baloxavir Marboxil
Nā huaʻōlelo like	BXM;S-033188
Helu CAS	1985606-14-1
Kūlana Kūʻai	Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā haneli kilogram
ʻĀpana Molekala	C27H23F2N3O7S
Kaumaha Molecular	571.55
ʻO ka mānoanoa	1.57±0.10 g/cm3
Ka hikiwawe	Hiki ke hoʻoheheʻe ʻia ma DMSO
Waihona Loihi	E mālama i ka wā lōʻihi ma -20 ℃
COA & MSDS	Loaʻa
Ke kumu	Shanghai, Kina
Brand	Kemika Ruifu

Nā kikoʻī:

'ikamu	Nā kikoʻī
Ka nana aku	Keʻokeʻo a hiki i ka pauda keʻokeʻo
ʻIkepili	Pili ka IR Spectrum i ka maʻamau kuhikuhi ʻO ka manawa paʻa e pili ana i ka maʻamau kuhikuhi
Waiwai (na KF)	≤1.0%
Nalo ma ka maloo	≤1.0%
Koena ma ka Ignition	≤0.50%
Nā Metala Kaumaha	≤20ppm
Na mea pili
ʻO ka haumia kanaka kiʻekiʻe	≤0.50%
Huina paumaele	≤1.0%
Ka nui o ka ʻāpana	D90 Pass 150um
Maʻemaʻe Chiral	≥99.0%
Maemae	≥99.0%
Hoʻāʻo	98.0%~102.0%
Nā mea hoʻoheheʻe koena	E hoʻokō me nā Koina ICH
Hoʻouna	Hoʻouna ʻana me ka ʻeke hau
Kūlana hoʻāʻo	Kūlana ʻoihana
Hoʻohana	API, i ka mālama ʻana i nā maʻi maʻi influenza A a me nā maʻi maʻi influenza B

Pūʻolo a me ka waiho ʻana:

Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.

Pono:

FAQ:

1985606-14-1 - Noi:

ʻO Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) he lāʻau antiviral i hoʻomohala ʻia e Shionogi Co., kahi hui lāʻau lapaʻau Iapana a me Roche no ka mālama ʻana i nā maʻi influenza A a me ka maʻi influenza B.Ua ʻae mua ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana ma Iapana i Pepeluali 2018 a ua ʻae ʻia e ka FDA ma ʻOkakopa 24, 2018 no ka mālama ʻana i ka maʻi maʻi maʻi uncomplicated i nā maʻi 12 mau makahiki a ʻoi aʻe ka mea i hōʻailona ʻia no ka ʻoi aku o 48 mau hola Label.ʻO Baloxavir marboxil, kahi mea hoʻopaneʻe cap-endonuclease, he hana kū hoʻokahi o ka hana ke hoʻohālikelike ʻia me ka papa lāʻau neuraminidase inhibitor i kēia manawa i hoʻohana ʻia no ka mālama ʻana i nā maʻi influenza.ʻO Baloxavir Marboxil kahi lāʻau anti influenza hou me ka hana hana hou.ʻO Baloxavir Marboxil ka prodrug o Baloxavir Acid (S-033447) e hoʻopaʻa ikaika a koho i ka endonuclease e pili ana i ka pāpale i loko o ka polymerase PA subunit o nā maʻi maʻi influenza A a me B, e alakaʻi ana i ka pale ʻana i ka transcription RNA a me ka replication.Ua ʻimi ʻia ʻo Baloxavir no kona hiki ke mālama i ka COVID-19 akā ʻaʻohe pono i ʻike ʻia.

1985606-14-1 - Mechanism of Action:

ʻO Baloxavir Marboxil kahi lāʻau lapaʻau maʻi influenza, ʻo ia hoʻi, he mea hoʻopaneʻe enzyme e kuhikuhi ana i ka hana endonuclease e pili ana i ka maʻi influenza, kekahi o nā hana o ka maʻi polymerase complex.ʻO ka mea kūikawā, ke kāohi nei ia i kahi kaʻina hana i kapa ʻia ʻo cap snatching, kahi i loaʻa ai i ka maʻi nā mea pōkole, i hoʻopaʻa ʻia mai nā transcripts RNA cell host, a laila hoʻohana ia no ka synthesis polymerase-catalyzed o kāna mau mRNA viral pono.Hoʻopaʻa ʻia kahi subunit polymerase i ka host pre-mRNAs ma ko lākou mau pāpale 5', a laila hoʻopaʻa ka hana endonuclease o ka polymerase i kona mahele "ma hope o 10-13 nucleotides".No laila, ʻokoʻa kona ʻano hana mai nā neuraminidase inhibitors e like me Oseltamivir a me Zanamivir.

1985606-14-1 - Pharmacokinetics:

ʻO Baloxavir Marboxil kahi mea paʻa koho o ka influenza cap-dependent endonuclease e pale ana i ka hana polymerase a no laila ka maʻi influenza mRNA replication 5, 3. Ua hōʻike ʻia ka hana therapeutic e kūʻē i nā maʻi maʻi influenza A a me B, e komo pū me nā ʻano kūʻē i nā mea antiviral o kēia manawa 1. ʻO kēia lāʻau lapaʻau. kaohi i ka enzyme koi 'ia no ka ho'opili hou 'ana, no laila e ho'opa'a koke 'ia ai ka ma'i ma'i ma'i 5, Lepili a me ka ho'ēmi 'ana i nā hō'ailona pili i ka ma'i.Ua hōʻike ʻia he ʻoi aku ka nui o ka maʻi maʻi ma mua o ka placebo i ka hoʻomaha ʻana i nā hōʻailona maʻi influenza a ʻoi aku ka maikaʻi ma mua o ka oseltamivir a me ka placebo i nā hopena virologic (i hōʻailona ʻia e ka hoʻemi ʻana i ka ukana viral).

1985606-14-1 - Nā hōʻailona:

Ua kūpono ʻo Baroxavir i nā mea maʻi ≥ 12 mau makahiki i loaʻa i ka maʻi maʻi maʻi uncomplicated a ʻaʻole i ʻoi aku nā hōʻailona ma mua o 48 mau hola.Pono e noʻonoʻo i nā palena o ka lāʻau lapaʻau: hoʻololi ka maʻi influenza i ka manawa, a aia kekahi mau mea e like me ke ʻano virus a me ka subtype.I ka manawa e hoʻololi ai ka pale ʻana i ka lāʻau o ka maʻi a me ka pathogenicity o ka maʻi maʻi, hiki ke hoʻonāwaliwali ʻia ka hana lapaʻau o nā lāʻau antiviral.Ke hoʻoholo nei inā e lawe i ka basalovir dipivoxil, pono e noʻonoʻo ʻia ka ʻike e pili ana i ka naʻau o ka maʻi maʻi maʻi kūloko i ka lāʻau.

1985606-14-1 - Hoʻohana:

ʻO Baloxavir Marboxil he lāʻau lapaʻau maʻi maʻi, he antiviral, i lawe ʻia ma ke ʻano he papa pākahi hoʻokahi, ma ka waha, e nā poʻe he 12 mau makahiki a ʻoi paha, i hōʻike i nā hōʻailona o kēia maʻi no nā hola 48. ʻO ka maikaʻi o ka ʻAʻole i hoʻāʻo ʻia ka baloxavir marboxil ma hope o 48 mau hola.

1985606-14-1 - Kū'ē:

ʻAʻole pono e hui pū ʻia ʻo Baloxavir Marboxil me nā huahana waiu, nā mea inu i hoʻopaʻa ʻia i ka calcium, a i ʻole nā laxatives, antacids, a i ʻole nā mea hoʻohui waha i loaʻa i ka calcium, iron, magnesium, selenium, alumini a zinc.

1985606-14-1 - Nā hopena ʻaoʻao:

ʻO nā hopena ʻaoʻao maʻamau ma hope o ka hoʻohana ʻana o ka baloxavir marboxil hoʻokahi me ka maʻi maʻi, bronchitis, ke anu maʻamau, ke poʻo, a me ka nausea.Ua hōʻike ʻia nā hanana ʻino i ka 21% o ka poʻe i loaʻa i ka baloxavir, 25% o ka poʻe i loaʻa i ka placebo, a me 25% o Oseltamivir.

1985606-14-1 - Hoʻomākaukau:

Ua hōʻike ka patent Japanese JP6212678 i ke ʻano synthesis o Baloxavir Marboxil.Ua hoʻohana ʻia ka 3, 4-difluorobenzoic acid ma ke ʻano he mea maka e hana me DMF ma lalo o ka hana a LDA e loaʻa ai ka 2-formyl-3, 4-difluorobenzoic acid.A laila, hana ia i ka thioacetal me ka thiophenol, a laila hoʻemi ʻia a hoʻokaʻawale ʻia me ka borane e loaʻa ai ka 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11(6H)-one, a ma hope o ka ʻāpana thiazepine kī. Loaʻa ka 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-alcohol ma lalo o ka hoʻemi ʻana o ka sodium borohydride.Ke hoʻohana nei i ka 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid e hana me ka tert-butyl formate ma hope o ka esterification e loaʻa ai ka 3-(benzyloxy)-1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, a laila me 2-(2, 2-dimethoxyethoxy) ethylamine e hoʻololi i ka urethane hoʻololi, a laila cyclizes ma lalo o ka hana o ka methanesulfonic acid e loaʻa ai ka 7-(benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f] [1,2,4] triazine -6, 8-dione hemihydrate, a laila ua condensed me (R) -tetrahydrofuran -2-formic acid, a laila crystallized a hoʻoholo 'ia, a laila, ua wehe 'ia ka hui kōkua chiral no ka loaʻaʻana o ke kī chiral makua apo mole (R) -7- (benzyloxy) -3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f][1,4] Triazine-6, 8-dione.A laila hoʻohana ʻia ka molekele apo makua kī e hoʻololi me ka n-hexanol ma lalo o ka hana a Grignard reagent, a laila me ke kī thiazepine ʻāpana 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-waiʻona docking , a me ka hoʻomaka mua ʻana a me ka condensation me ka methyl chloroformate e loaʻa ai ka huahana hope Baloxavir Marboxil.