Boc-His(Dnp)-OH·IPA CAS 25024-53-7 Purity >98.5% (HPLC)

ʻO Boc-His(Dnp)-OH·IPA (CAS: 25024-53-7), paʻa ka hui Dnp iā HF a me TFMSA.Nā amino acids a me nā derivatives, peptide synthesis, pharmaceutical intermediates, biochemical reagents.Ma ke ʻano he kumu hoʻohālikelike maʻamau o L-Histidine, ua loaʻa ʻo Boc-His(Dnp)-OH·IPA i ka nui o ka nānā ʻana ma ke kahua o ka lāʻau lapaʻau a me ka ʻoihana kemika.
Hoʻomākaukau ʻO ka hoʻohana ʻana i ka 2,4-Dinitrophenyl-L-Histidine ma ke ʻano he mea hoʻomaka, ua hoʻomākaukau ʻia ka pūhui pahuhopu N-(tert-Butoxycarbonyl)-1-(2, 4-Dinitrophenyl)-L-Histidine e ka hopena pale amino me ditert-butyl dicarbonate.Fig. 1 hoʻokolohua hoʻokolohua o ka synthesis reaction formula o N-(tert-Butoxycarbonyl)-1-(2, 4-Dinitrophenyl)-L-Histidine: 2,4-Dinitrophenyl-L-Histidine ua hoʻoheheʻe ʻia i loko o 100mL o ka wai wai sodium hydroxide. , 200mL o ka tetrahydrofuran a me 250g o ditert-butyl dicarbonate i hoʻohui pūʻia, e mālamaʻia ka pH waiwai i ka 8-9, a ma hope o ka 12h o ka hopena, e laweʻia ka ethyl acetate iʻelua manawa, 500mL i kēlā me kēia manawa;Hoʻohana ʻia ka HCI no ka hoʻokahe ʻana i ka ʻāpana wai i kahi waiwai pH o 1-2, a hoʻohana ʻia ka ethyl acetate e unuhi i ka huahana 3 manawa, 500mL i kēlā me kēia manawa.Hoʻohui ʻia nā papa ester a holoi ʻia ʻelua me ka brine saturated, 200 ml.E maloʻo me ka sodium sulfate anhydrous no 12h, kānana, concentrate a crystallize, a maloʻo ma 40-50 ℃ e loaʻa ai ka N-(tert-Butoxycarbonyl) -1-(2, 4-Dinitrophenyl) -L-Histidine.