Brexpiprazole CAS 913611-97-9 Maʻemaʻe >99.0% (HPLC) API Hale Hana
ʻO Ruifu Chemical Supply Brexpiprazole Intermediates
Brexpiprazole CAS 913611-97-9
7-Hydroxyquinolinone CAS 70500-72-0
4-Bromobenzo[b]thiophene CAS 5118-13-8
1-(1-Benzothiophen-4-yl)piperazine Hydrochloride CAS 913614-18-3
7-(4-Chlorobutoxy)quinolin-2(1H)-hoʻokahi CAS 913613-82-8
4-Chlorobenzo[b]thiophene CAS 66490-33-3
Inoa Kimia | ʻO Brexpiprazole |
Nā huaʻōlelo like | OPC-34712;7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one |
Helu CAS | 913611-97-9 |
Helu CAT | RF-PI1982 |
Kūlana Kūʻai | Ma ka waihona, hoʻonui ʻia a hiki i nā tona |
ʻĀpana Molekala | C25H27N3O2S |
Kaumaha Molecular | 433.57 |
ʻO ka mānoanoa | 1.245±0.060 g/cm3 |
Brand | Kemika Ruifu |
'ikamu | Nā kikoʻī |
Ka nana aku | Keʻokeʻo a i ʻole ke keʻokeʻo Crystalline pauda |
ʻIkepili | Na IR |
RT | Ma lalo o chirality pono e hoʻokō |
Klorida | Hāʻawi ia i ka hopena o ka chloride |
Wai | 3.0%~4.5% |
Lae hehee | 198.0~202.0 ℃ |
Koena ma ka Ignition | <0.20% |
Nā Metala Kaumaha | ≤10ppm |
Na mea pili | |
Ka haumia o ke kanaka | <0.50% |
Huina paumaele | <1.00% |
EE | >99.0% |
Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC, ma ke kumu maloʻo) |
Kūlana hoʻāʻo | Kūlana ʻoihana |
Hoʻohana | API |
Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai
ʻO Brexpiprazole (CAS: 913611-97-9) he moho lāʻau kūpono i ka mālama ʻana a me ka pale ʻana i nā maʻi noʻonoʻo me nā maʻi CNS.ʻO Brexpiprazole kahi lāʻau antipsychotic hou e lawelawe nei ma ke ʻano he serotonin ® dopamine activity modulator a ua hōʻike i ka pono ma ke ʻano he lāʻau hoʻohui i nā maʻi me ka maʻi depressive nui (MDD).Hōʻike ʻo Brexpiprazole i kahi ʻano lāʻau lapaʻau kūʻokoʻa, e hana ana ma ke ʻano he agonist ʻāpana o ka serotonin 5-HT1A a me ka dopamine D2 receptors a ma ke ʻano he antagonist piha o 5-HT2A a me noradrenaline α1B / 2C receptors, me ka subnanomolar binding affinity.Ua hoʻomohala ʻia ʻo Brexpiprazole e Otsuka a me Lundbeck, ua ʻae ʻia ma 2015 e ka FDA no ka mālama ʻana i ka schizophrenia a ma ke ʻano he lāʻau hoʻohui no ke kaumaha.Ua manaʻo nui ʻia ʻo Brexpiprazole he mea pani i ka lāʻau lapaʻau antipsychotic o Otsuka aripiprazole (inoa kālepa Abilify) i pau ka patent i ʻAukake 2014.