Brigatinib CAS 1197953-54-0 Maʻemaʻe >99.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Brigatinib (AP-26113) (CAS: 1197953-54-0) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku iā Brigatinib,Please contact: alvin@ruifuchem.com
Inoa Kimia | ʻO Brigatinib |
Nā huaʻōlelo like | AP26113;AP-26113;5-Chloro-N4-[2-(Dimethylphosphinyl)phenyl]-N2-[2-Methoxy-4-[4-(4-Methyl-1-Piperazinyl)-1-Piperidinyl]phenyl]-2,4-Pyrimidinediamine |
Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
Helu CAS | 1197953-54-0 |
ʻĀpana Molekala | C29H39ClN7O2P |
Kaumaha Molecular | 584.09 g/mol |
Lae hehee | >203℃(Dek.) |
ʻO ka mānoanoa | 1.31±0.10 g/cm3 |
COA & MSDS | Loaʻa |
Ke kumu | Shanghai, Kina |
Brand | Kemika Ruifu |
Nā mea | Nā kikoʻī | Nā hualoaʻa |
Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo | Hoʻokō |
Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) | 99.26% |
Max.Hoʻokahi haumia | <1.00% | 0.25% |
Nalo ma ka maloo | <1.00% | 0.27% |
Infrared Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
1H NMR Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō me nā kikoʻī i hāʻawi ʻia |
Pūʻolo:ʻO ka ʻōmole Fluorinated, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a me ka makani maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
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Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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ʻO ka Brigatinib (AP-26113) (CAS: 1197953-54-0) he mea noiʻi liʻiliʻi-mole i hoʻopaʻa ʻia i ka maʻi maʻi kanesa i hoʻomohala ʻia e ARIAD Pharmaceuticals, Inc. anaplastic lymphoma kinase (ALK).ʻO Brigatinib kahi agonist koho e kūʻē i nā ʻano like ʻole o EGFR e kū'ē i nā ʻano mutant wild.Hōʻike pū ka lāʻau lapaʻau i ke koho ʻana i ka ALK-EML4 fusion gene, kahi ʻano kumu o ka hoʻololi ʻana o ka parenchyma māmā.Ua kuhikuhi ʻia ʻo Brigatinib no nā poʻe maʻi me nā ʻano genes kūikawā a i ka wā e pane ʻole ai ka maʻi maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi (NSCLC) i ka hoʻokele me nā lāʻau lapaʻau ʻē aʻe.Hoʻokaʻawale ʻia ʻo Brigatinib ma ke ʻano he kinase inhibitor, nona ka hana o ka hana e hoʻopau i ka hana o nā protein abnormal e hoʻonui ai i ka hoʻonui ʻana o nā maʻi kanesa.
Ua kuhikuhi ʻia ʻo Brigatinib (CAS: 1197953-54-0) no nā poʻe maʻi me nā ʻano kikoʻī o NSCLC i laha i nā ʻāpana like ʻole o ke kino i ka poʻe i mālama mua ʻia me nā lāʻau maʻi maʻi ʻē aʻe e like me Crizotinib, a ua ʻoi aku ka ʻino o ko lākou kūlana. a i ʻole hōʻike lākou i nā hōʻailona liʻiliʻi o ka hoʻomaikaʻi.Ke noiʻi nui ʻia nei no ka maikaʻi o ka mālama ʻana i ka maʻi maʻi ʻaʻai māmā liʻiliʻi liʻiliʻi (NSCLC) kahi i hoʻāla ʻia ai ka ALK a loaʻa pinepine nā hoʻololi EGFP.
ʻO Brigatinib (AP-26113) (CAS: 1197953-54-0) he mea hoʻopaneʻe hou o tyrosine kinase, e hōʻike ana i ka pono nui i ka ALK + metastatic NSCLC.Ma ʻAukake 30, 2016, ua hāʻawi ka United States FDA i ka bugtinib ma ke ʻano he breakthrough therapy a me ka lāʻau lapaʻau laha loa no ALK+NSCLC i nā poʻe maʻi i hoʻomohala a ʻaʻole hiki ke ʻae iā Crizotinib, ka lāʻau mua o ALK+NSCLC.Hāʻawi i ka mea nui i ka loiloi noi papa inoa a ʻae i ka ʻikepili noi e waiho ʻia ma ke ʻano holo.Ua ʻae ka FDA iā Bugtinib ma ʻApelila 28, 2017, ma lalo o ka inoa kālepa ʻo Alunbrigtm.