Carvedilol CAS 72956-09-03 Maʻemaʻe >99.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Carvedilol (CAS: 72956-09-03) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.Kūʻai iā Carvedilol,Please contact: alvin@ruifuchem.com
Nā Intermediates pili o Carvedilol
Inoa Kimia | ʻO Carvedilol |
Nā huaʻōlelo like | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Artist;Cadilan;Carca;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190 |
Kūlana Kūʻai | Ma ka waihona, GMP Commercial |
Helu CAS | 72956-09-3 |
ʻĀpana Molekala | C24H26N2O4 |
Kaumaha Molecular | 406.48 g/mol |
Lae hehee | 115.0 a 119.0 ℃ |
ʻO ka mānoanoa | 1.250±0.06 g/cm3 |
Solubility i ka wai | ʻAʻole hiki ke hoʻonā i ka wai |
Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka Methanol.Hiki ke hoʻoheheʻe ʻia i loko o ka Ethanol, Etera |
Waihona Temp. | Wahi anuanu a maloo (2~8 ℃) |
COA & MSDS | Loaʻa |
Brand | Kemika Ruifu |
Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
Ka nana aku | Pauda Crystal Keʻokeʻo | Hoʻokō |
Nalo ma ka maloo | ≤0.50% (105 ℃ no 3 hola) | 0.25% |
Koena ma ka Ignition | ≤0.10% | 0.07% |
Na mea pili | ||
Huina paumaele | ≤0.50% | Hoʻokō |
haumia A | ≤0.20% | Hoʻokō |
haumia C | ≤0.02% | Hoʻokō |
ʻO nā mea haumia ʻē aʻe | ≤0.10% | Hoʻokō |
Nā Metala Kaumaha (Pb) | ≤10ppm | <10ppm |
Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) | 99.72% |
Infrared Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō i nā kikoʻī |
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o kahi pahu paʻa.E kūʻai i loko o kahi hale kūʻai maloʻo, maloʻo (2 ~ 8 ℃) a me ka ventilated maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
Mākeke Nui?E kūʻai aku i ka mākeke kūloko, ʻAmelika ʻĀkau, ʻEulopa, India, Korea, Iapana, Australia, etc.
Nā pono?ʻO ke kūlana kiʻekiʻe, ke kumukūʻai kūpono, nā lawelawe ʻoihana a me ke kākoʻo ʻenehana, ka lawe wikiwiki ʻana.
ʻAno maikaʻiHōʻoiaʻiʻo?Pūnaehana hoʻomalu maikaʻi koʻikoʻi.ʻO nā lako ʻoihana no ka nānā ʻana ʻo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.
Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
MOQ?ʻAʻohe MOQ.ʻAe ʻia ke kauoha liʻiliʻi.
Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.
Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.
Nā palapala?Ma hope o ka lawelawe kūʻai: COA, MOA, ROS, MSDS, etc.
Hoʻohui Kuʻuna?Hiki ke hāʻawi i nā lawelawe synthesis maʻamau e kūpono i kāu mau pono noiʻi.
Kūkākūkā uku?E hoʻouna mua ʻia ka invoice Proforma ma hope o ka hōʻoia ʻana o ke kauoha, hoʻopili ʻia kā mākou ʻike panakō.Uku e T/T (Telex Transfer), PayPal, Western Union, etc.
Nā Code Hazard N,Xn
Hōʻike pilikia 51/53-36/37/38-20/21/22
ʻŌlelo Palekana 61-36-26
RIDADR UN 3077 9/PG 3
WGK Kelemānia 3
RTECS UA8670000
PALAPALA PALAPALA
Hui Puupuu III
ʻIkepili Mea Pilikino 72956-09-3(ʻIkepili Mea Pilikino)
ʻona LD50 waha i ka ʻīlio: > 1gm/kg
ʻO Carvedilol (CAS: 72956-09-03) he vasodilating beta-blocker pono i ka mālama ʻana i ka hypertension a me ka angina pectoris.Ma waho aʻe o ka hoʻohaʻahaʻa ʻana i ke koko, hoʻemi ʻo carvedilol i ka nui o ke kūpaʻa vascular me ka ʻole o ka tachycardia reflex e hana pinepine ʻia me nā vasodilators.Ua hōʻike ʻia e ʻae maikaʻi ʻia me nā hopena sparing renal.
Ua hoʻokuʻu mua ʻia ʻo Carvedilol ma Belgium i ka makahiki 1985. Hiki i kēia huahana ke kāohi i ka alpha a me ka beta receptors, ʻaʻohe hana intrinsic, i nā kiʻekiʻe kiʻekiʻe o ke ʻano me ka antagonism calcium.He hopena koʻikoʻi ia o ka pale ʻana i nā mea loaʻa beta, hiki ke hoʻonui i nā kīʻaha koko, hoʻemi i ke kūʻē peripheral a hoʻohaʻahaʻa i ke koko, a ʻaʻohe hopena liʻiliʻi i ka hopena o ka naʻau a me ka puʻuwai puʻuwai.Hiki ke hoʻohana ʻia ka lāʻau lapaʻau no ka hypertension mua a me ka angina pectoris.
rU= | pane kiʻekiʻe o carvedilol mai ka hāʻina hāpana |
rS= | pane kiʻekiʻe o carvedilol mai ka hoʻonā Kūlana |
CS= | ka hoʻopaʻa ʻana o ka carvedilol i ka hopena maʻamau (mg/mL) |
CU= | ka hoʻopaʻa ʻana o Carvedilol i loko o ka hāpana laʻana (mg/mL) |
rU | = | pane kiʻekiʻe o ka hui pili pili a i ʻole nā mea haumia ʻē aʻe mai ka hāʻina Laʻana |
rS | = | pane kiʻekiʻe o ka pūhui pili pili mai ka hoʻonā Kūlana.No ka helu ʻana i ka pākēneka o nā mea haumia ʻē aʻe e hoʻohana i ka pane kiʻekiʻe o carvedilol. |
CS | = | ka hoʻopaʻa ʻana o ka pūhui pili e pili ana i ka hoʻonā maʻamau (mg/mL).No ka helu ʻana i ka pākēneka o nā mea haumia ʻē aʻe no CS, e hoʻohana i ka neʻe ʻana o USP Carvedilol RS. |
CU | = | ka hoʻopaʻa ʻana o Carvedilol i loko o ka hāpana laʻana (mg/mL) |
inoa | Manawa Paa Pilina | Nā Koina ʻae, NMT (%) | |
Carvedilol pili pūhui Ea | 0.35 | 0.1 | |
Carvedilol pili pūhui Ab | 0.52 | 0.1 | |
Carvedilol bisalkylpyrocatechol derivative (inā loaʻa)c | 0.70 | 0.15 | |
ʻO Carvedilol | 1.0 | — | |
Carvedilol pili pūhui Cd | 3.6 | 0.02 | |
ʻO ka hui pili Carvedilol De | 5.0 | 0.1 | |
ʻO ka hui pili Carvedilol Bf | 8.5 | 0.1 | |
ʻO nā mea haumia ʻē aʻe | - | 0.10 | |
Huina haumia | - | 0.5g | |
he 2-(2-Methoxyphenoxy)ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy)-9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Haʻalele i ka haumia ma lalo o 0.01%. |
Manawa (min) | Hoʻoholo A (%) | Pane B (%) |
---|---|---|
0 | 22 | 78 |
20 | 22 | 78 |
33 | 38 | 62 |
45 | 38 | 62 |
55 | 55 | 45 |
65 | 55 | 45 |
68 | 22 | 78 |
80 | 22 | 78 |
rU | = | pane kiʻekiʻe no kēlā me kēia haumia i ka hāʻina Laʻana |
rT | = | ka huina o na pane kiʻekiʻe a pau ma ka Haʻina Haʻina |
inoa | Hoahanau Paʻa Manawa | ʻO ka ʻae ʻana Koina, NMT (%) | |
---|---|---|---|
Carvedilol pili pūhui Aa | 0.7 | 0.1 | |
ʻO Carvedilol | 1.0 | — | |
ʻO ka hui pili Carvedilol Fb | 1.2 | 0.1c | |
N-Isopropylcarvedilold | 1.6 | 0.1 | |
Carvedilol pili pūhui Ce | 1.8 | 0.02 | |
ʻO ka hui pili Carvedilol Bf | 2.1 | 0.1 | |
ʻO Biscarbazoleg | 3 | 0.1 | |
ʻO nā mea haumia ʻē aʻe | — | 0.1 | |
Huina haumia | — | 0.5 | |
he 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1-(2-(2-Methoxyphenoxy)ethylamino)-3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol. c Ua helu ʻia kēia haumia me ka hoʻohana ʻana i ke kaʻina hana ma lalo o Organic Impurities, Kaʻina 3: Carvedilol Related Compound F. d 1-(H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino]-2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol. |
rU | = | pane kiʻekiʻe o carvedilol pili pūhui F mai ka Haʻawina Haʻawina |
rT | = | ka huina o nā pane kiʻekiʻe o carvedilol a me carvedilol pili pūhui F mai ka hāpana Laʻana |
F | = | kumu pane pili, 1.1 |
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60
4-(Oxiran-2-ylmethoxy)-9H-carbazole.
C15H13NO2 239.27
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21
Ka hui pū ʻana o 0.1% carvedilol pili pūhui F (1-(2-(2-Methoxyphenoxy)ethylamino)-3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) i loko o kahi matrix o carvedilol lāʻau lāʻau.