Carvedilol CAS 72956-09-03 Maʻemaʻe >99.0% (HPLC)

ʻO ka wehewehe pōkole:

Inoa Kemika: Carvedilol

CAS: 72956-09-03

Maʻemaʻe: >99.0% (HPLC)

ʻAno: ʻO ka pauka kristal keʻokeʻo

Hoʻokaʻaʻike: Kauka Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Huahana Huahana

Nā Huahana Pili

Huahana Huahana

wehewehe:

ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Carvedilol (CAS: 72956-09-03) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.Kūʻai iā Carvedilol,Please contact: alvin@ruifuchem.com

Nā Kūwaena Pili:

Na Waiwai Kemika:

Inoa Kimia ʻO Carvedilol
Nā huaʻōlelo like 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Artist;Cadilan;Carca;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Kūlana Kūʻai Ma ka waihona, GMP Commercial
Helu CAS 72956-09-3
ʻĀpana Molekala C24H26N2O4
Kaumaha Molecular 406.48 g/mol
Lae hehee 115.0 a 119.0 ℃
ʻO ka mānoanoa 1.250±0.06 g/cm3
Solubility i ka wai ʻAʻole hiki ke hoʻonā i ka wai
Ka hikiwawe Hiki ke hoʻoheheʻe ʻia i ka Methanol.Hiki ke hoʻoheheʻe ʻia i loko o ka Ethanol, Etera
Waihona Temp. Wahi anuanu a maloo (2~8 ℃)
COA & MSDS Loaʻa
Brand Kemika Ruifu

Nā kikoʻī:

Nā mea Nā Kūlana Nānā Nā hualoaʻa
Ka nana aku Pauda Crystal Keʻokeʻo Hoʻokō
Nalo ma ka maloo ≤0.50% (105 ℃ no 3 hola) 0.25%
Koena ma ka Ignition ≤0.10% 0.07%
Na mea pili    
Huina paumaele ≤0.50% Hoʻokō
haumia A ≤0.20% Hoʻokō
haumia C ≤0.02% Hoʻokō
ʻO nā mea haumia ʻē aʻe ≤0.10% Hoʻokō
Nā Metala Kaumaha (Pb) ≤10ppm <10ppm
Maʻemaʻe / Kaʻina Hanana >99.0% (HPLC) 99.72%
Infrared Spectrum Kūlike i ka hoʻolālā Hoʻokō
Ka hopena Ua hoʻāʻo ʻia ka huahana a hoʻokō i nā kikoʻī

Pūʻolo/Paʻa/Hoʻouna:

Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o kahi pahu paʻa.E kūʻai i loko o kahi hale kūʻai maloʻo, maloʻo (2 ~ 8 ℃) a me ka ventilated maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.

Pono:

ʻO ka mana kūpono: lawa nā lako a me nā ʻenehana

ʻOihana Hoʻonaʻauao: Hoʻokahi lawelawe kūʻai kūʻai

Puke OEM: Loaʻa ka pūʻolo maʻamau a me ka lepili

Hoʻouna wikiwiki: Inā i loko o ke kumukūʻai, ʻekolu lā hoʻouna i hōʻoia ʻia

Hoʻolako Paʻa: E mālama i ka waiwai kūpono

Kākoʻo ʻenehana: Loaʻa ka hopena ʻenehana

Hana Hana Hana Kuʻuna: Mai ka grama a hiki i ke kilo

Kūlana Kiʻekiʻe: Hoʻokumu i kahi ʻōnaehana hōʻoia maikaʻi piha

FAQ:

Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā ​​​​kemika maikaʻi.

Mākeke Nui?E kūʻai aku i ka mākeke kūloko, ʻAmelika ʻĀkau, ʻEulopa, India, Korea, Iapana, Australia, etc.

Nā pono?ʻO ke kūlana kiʻekiʻe, ke kumukūʻai kūpono, nā lawelawe ʻoihana a me ke kākoʻo ʻenehana, ka lawe wikiwiki ʻana.

ʻAno maikaʻiHōʻoiaʻiʻo?Pūnaehana hoʻomalu maikaʻi koʻikoʻi.ʻO nā lako ʻoihana no ka nānā ʻana ʻo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.

Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.

MOQ?ʻAʻohe MOQ.ʻAe ʻia ke kauoha liʻiliʻi.

Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.

Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.

Nā palapala?Ma hope o ka lawelawe kūʻai: COA, MOA, ROS, MSDS, etc.

Hoʻohui Kuʻuna?Hiki ke hāʻawi i nā lawelawe synthesis maʻamau e kūpono i kāu mau pono noiʻi.

Kūkākūkā uku?E hoʻouna mua ʻia ka invoice Proforma ma hope o ka hōʻoia ʻana o ke kauoha, hoʻopili ʻia kā mākou ʻike panakō.Uku e T/T (Telex Transfer), PayPal, Western Union, etc.

72956-09-3 - ʻIke Palekana:

Nā Code Hazard N,Xn
Hōʻike pilikia 51/53-36/37/38-20/21/22
ʻŌlelo Palekana 61-36-26
RIDADR UN 3077 9/PG 3
WGK Kelemānia 3
RTECS UA8670000
PALAPALA PALAPALA
Hui Puupuu III
ʻIkepili Mea Pilikino 72956-09-3(ʻIkepili Mea Pilikino)
ʻona LD50 waha i ka ʻīlio: > 1gm/kg

72956-09-3 -Noi:

ʻO Carvedilol (CAS: 72956-09-03) he vasodilating beta-blocker pono i ka mālama ʻana i ka hypertension a me ka angina pectoris.Ma waho aʻe o ka hoʻohaʻahaʻa ʻana i ke koko, hoʻemi ʻo carvedilol i ka nui o ke kūpaʻa vascular me ka ʻole o ka tachycardia reflex e hana pinepine ʻia me nā vasodilators.Ua hōʻike ʻia e ʻae maikaʻi ʻia me nā hopena sparing renal.

Ua hoʻokuʻu mua ʻia ʻo Carvedilol ma Belgium i ka makahiki 1985. Hiki i kēia huahana ke kāohi i ka alpha a me ka beta receptors, ʻaʻohe hana intrinsic, i nā kiʻekiʻe kiʻekiʻe o ke ʻano me ka antagonism calcium.He hopena koʻikoʻi ia o ka pale ʻana i nā mea loaʻa beta, hiki ke hoʻonui i nā kīʻaha koko, hoʻemi i ke kūʻē peripheral a hoʻohaʻahaʻa i ke koko, a ʻaʻohe hopena liʻiliʻi i ka hopena o ka naʻau a me ka puʻuwai puʻuwai.Hiki ke hoʻohana ʻia ka lāʻau lapaʻau no ka hypertension mua a me ka angina pectoris.

72956-09-3 - USP 35 Kūlana:

HOAKAKA
Loaʻa iā Carvedilol NLT 98.0% a me NMT 102.0% o C24H26N2O4, helu ʻia ma ke kumu maloʻo.
IKE
• A. Hoʻopili ʻana i ka infrared <197K>
B. ʻO ka manawa paʻa o ke kiʻekiʻe nui o ka hāʻina Laʻana e pili ana i ka hopena maʻamau, e like me ka loaʻa ʻana ma ka Assay.
HANA
• Kaʻina hana
Hoʻopaʻa: 2.72 g/L o monobasic potassium phosphate.Hoʻoponopono me ka waika phosphoric dilute i kahi pH o 2.0.
ʻĀpana paʻa: Acetonitrile a me Buffer (31:69)

ʻO ka hoʻonā kūpono o ka ʻōnaehana: 0.05 mg/mL kēlā me kēia o USP Carvedilol RS a me USP Carvedilol Related Compound A RS ma ka pae Mobile.
Haʻina maʻamau: 0.04 mg/mL o USP Carvedilol RS ma ka pae Mobile
Laʻana hoʻonā: 0.04 mg/mL o Carvedilol i ka pae Mobile
Pūnaehana Chromatographic

(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC
ʻIke: UV 240 nm
kolamu: 4.6-mm × 15-cm;5-µm paʻi L7
Ka wela o ke kolamu: 55 ℃
Kahe kahe: 1 mL / min
Ka manawa holo: 60 min
Ka nui o ka hoʻopio: 10 µL
Kūpono ʻōnaehana

Laʻana: Haʻina kūpono ʻōnaehana
Nā koi kūpono

Hoʻoholo: NLT 4.0 ma waena o carvedilol a me carvedilol pili pūhui A
Ke kumu huelo: NMT 1.5 no ka piko carvedilol
Wehewehe maʻamau pili: NMT 2%
Kānāwai

Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o carvedilol (C24H26N2O4) ma ka ʻāpana o ka hāpana i lawe ʻia:
Ka hopena = (rU/rS) × (CS/CU) × 100
rU= pane kiʻekiʻe o carvedilol mai ka hāʻina hāpana
rS= pane kiʻekiʻe o carvedilol mai ka hoʻonā Kūlana
CS= ka hoʻopaʻa ʻana o ka carvedilol i ka hopena maʻamau (mg/mL)
CU= ka hoʻopaʻa ʻana o Carvedilol i loko o ka hāpana laʻana (mg/mL)
Nā pae hoʻoholo: 98.0% -102.0% ma ke kumu maloʻo
NA mea haumia
• Ke koena ma ka Ignition <281>: NMT 0.1% mai 1 g
• Nā Metala Kaumaha, Hana II <231>: NMT 10 ppm
• Nā Haumāna Organic, Ke Kaʻina Hana 1: [Note-Ma ke kumu o nā haumia i loaʻa, e hana i nā Organic Impurities, Procedure 1 a i ʻole Organic Impurities, Kaʻina 2. Organic Impurities, Procedure 2 i manaʻo ʻia inā he mea haumia ka hui carvedilol pili F.]

Buffer and Mobile phase: E hoʻomākaukau e like me ke kuhikuhi ʻana ma ka Assay.
ʻO ka hoʻonā kūpono o ka ʻōnaehana: 0.05 mg/mL kēlā me kēia o USP Carvedilol RS a me USP Carvedilol Related Compound C RS ma ka pae Mobile.
ʻO ka hoʻonā maʻamau: 1 µg/mL kēlā me kēia o USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, a me USP Carvedilol Related Compound E RS, a me 0.2 µg/mL o USP Carvedilol Puhui C RS pili i ka pae Mobile
Laʻana hoʻonā: 1 mg/mL o Carvedilol i ka pae Mobile
Pūnaehana Chromatographic
(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC

ʻIke: ʻElua nalu nalu, UV 220 a me 240 nm.E hoʻohana i ka 220 nm no ka helu ʻana i ka hui carvedilol pili E, a e hoʻohana i ka 240 nm no ka carvedilol a me nā mea pili ʻē aʻe a pau.
kolamu: 4.6-mm × 15-cm;5-µm paʻi L7
Ka wela o ke kolamu: 55 ℃
Kahe kahe: 1 mL / min
Ka nui o ka hoʻopio: 20 µL
Kūpono ʻōnaehana

Laʻana: Haʻina kūpono ʻōnaehana
Nā koi kūpono

Hoʻoholo: NLT 17 ma waena o carvedilol a me carvedilol pili pūhui C
Kānāwai
Nā Laʻana: Haʻina maʻamau a me ka hāʻina Laʻana
E helu i ka pākēneka o carvedilol pili pūhui A, carvedilol pili pūhui B, carvedilol pili pūhui C, carvedilol pili pūhui D, carvedilol pili pūhui E, a me kekahi mea haumia kanaka ma ka hapa o Carvedilol lawe:
Ka hopena = (rU/rS) × (CS/CU) × 100
rU = pane kiʻekiʻe o ka hui pili pili a i ʻole nā ​​mea haumia ʻē aʻe mai ka hāʻina Laʻana
rS = pane kiʻekiʻe o ka pūhui pili pili mai ka hoʻonā Kūlana.No ka helu ʻana i ka pākēneka o nā mea haumia ʻē aʻe e hoʻohana i ka pane kiʻekiʻe o carvedilol.
CS = ka hoʻopaʻa ʻana o ka pūhui pili e pili ana i ka hoʻonā maʻamau (mg/mL).No ka helu ʻana i ka pākēneka o nā mea haumia ʻē aʻe no CS, e hoʻohana i ka neʻe ʻana o USP Carvedilol RS.
CU = ka hoʻopaʻa ʻana o Carvedilol i loko o ka hāpana laʻana (mg/mL)
Nā pae ʻae ʻae: E nānā i ka Papa 1.

Papa 1
inoa Manawa Paa Pilina Nā Koina ʻae, NMT (%)
Carvedilol pili pūhui Ea 0.35 0.1
Carvedilol pili pūhui Ab 0.52 0.1
Carvedilol bisalkylpyrocatechol derivative (inā loaʻa)c 0.70 0.15
ʻO Carvedilol 1.0
Carvedilol pili pūhui Cd 3.6 0.02
ʻO ka hui pili Carvedilol De 5.0 0.1
ʻO ka hui pili Carvedilol Bf 8.5 0.1
ʻO nā mea haumia ʻē aʻe - 0.10
Huina haumia - 0.5g
he 2-(2-Methoxyphenoxy)ethyl amine.
b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol.
c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol).
d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
e 4-(Oxiran-2-ylmethoxy)-9H-carbazole.
f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
g Haʻalele i ka haumia ma lalo o 0.01%.
• Nā mea haumia kino, ke kaʻina hana 2

Pane A: Acetonitrile a me trifluoroacetic acid (100:0.1)
Pane B: ʻAka Trifluoroacetic a me ka wai (0.1:100)
Mea hoʻoheheʻe: Acetonitrile, trifluoroacetic acid, a me ka wai (22:0.1:78)
Māhele kelepona: E nānā i ka Papa 2
Papa 2
Manawa
(min)
Hoʻoholo A
(%)
Pane B
(%)
0 22 78
20 22 78
33 38 62
45 38 62
55 55 45
65 55 45
68 22 78
80 22 78
Haʻina kūpono ʻōnaehana: 1.0 mg/mL o ka USP Carvedilol System Suitability Mixture RS ma ka Diluent
Laʻana hoʻonā: 1 mg/mL o Carvedilol i Diluent
Pūnaehana Chromatographic
(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC
ʻIke: UV 240 nm
kolamu: 4.6-mm x 15-cm;5-µm paʻi L68
Ka wela o ke kolamu: 30 ℃
Kahe kahe: 1.4 mL / min
Ka nui o ka hoʻopio: 20 µL
Kūpono ʻōnaehana
Laʻana: Haʻina kūpono ʻōnaehana
Nā koi kūpono
Hoʻoholo: NLT 1.8 ma waena o carvedilol a me carvedilol pili pūhui F
Kānāwai
Laʻana: Laʻana hoʻonā
E helu i ka pākēneka o kēlā me kēia haumia i ka ʻāpana o Carvedilol i lawe ʻia:
Ka hopena = (rU/rT) × 100
rU = pane kiʻekiʻe no kēlā me kēia haumia i ka hāʻina Laʻana
rT = ka huina o na pane kiʻekiʻe a pau ma ka Haʻina Haʻina
Nā mea e ʻae ai: E nānā i ka Papa 3.
Papa 3

inoa Hoahanau
Paʻa
Manawa
ʻO ka ʻae ʻana
Koina,
NMT (%)
Carvedilol pili pūhui Aa 0.7 0.1
ʻO Carvedilol 1.0
ʻO ka hui pili Carvedilol Fb 1.2 0.1c
N-Isopropylcarvedilold 1.6 0.1
Carvedilol pili pūhui Ce 1.8 0.02
ʻO ka hui pili Carvedilol Bf 2.1 0.1
ʻO Biscarbazoleg 3 0.1
ʻO nā mea haumia ʻē aʻe 0.1
Huina haumia 0.5
he 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol .
b 1-(2-(2-Methoxyphenoxy)ethylamino)-3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol.
c Ua helu ʻia kēia haumia me ka hoʻohana ʻana i ke kaʻina hana ma lalo o Organic Impurities, Kaʻina 3: Carvedilol Related Compound F.
d 1-(H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino]-2-propanol.
e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol.
• Nā mea haumia kino, ke kaʻina hana 3: Carvedilol Related Compound F (inā loaʻa)

Pane A: ʻAka Trifluoroacetic a me ka wai (0.5:100)
Pane B: Methanol a me trifluoroacetic acid (100:0.5)
Mea hoʻoheheʻe: ka wai a me ka acetonitrile (1: 1)
Māhele paʻa lima: Haʻina A a me B (65:35)
Hoʻonā kūpono ʻōnaehana: 1.5 mg/mL o ka USP Carvedilol System Suitability Mixture RS ma ka Diluent
Laʻana hoʻonā: 1.5 mg/mL o Carvedilol i Diluent i hoʻomākaukau ʻia penei.E hoʻohana ma kahi o 1.9 mL o Diluent no ka mg o ka Carvedilol, a sonicate pōkole e hoʻomaʻamaʻa i ka hemo.
Pūnaehana Chromatographic

(E nana Chromatography <621>, Pūnaehana Pono.)
Ke ano: LC
ʻIke: UV 226 nm
kolamu: 4.6-mm × 30-mm;3-µm paʻi L7
Ka wela o ke kolamu: 40 ℃
Kahe kahe: 2 mL / min
Ka nui o ka hoʻopio: 10 µL
Kūpono ʻōnaehana
Laʻana: Haʻina kūpono ʻōnaehana
Nā koi kūpono
Hoʻoholo: NLT 2.0 ma waena o carvedilol a me carvedilol pili pūhui F
Kānāwai
Laʻana: Laʻana hoʻonā
E helu i ka pākēneka o ka hui carvedilol pili F ma ka ʻāpana o ka hāpana i lawe ʻia:
Ka hopena = (rU/rT) × (1/F) × 100
rU = pane kiʻekiʻe o carvedilol pili pūhui F mai ka Haʻawina Haʻawina
rT = ka huina o nā pane kiʻekiʻe o carvedilol a me carvedilol pili pūhui F mai ka hāpana Laʻana
F = kumu pane pili, 1.1
Nā pae ʻae ʻae: NMT 0.1%
NA HOAO KUAI
• Pohō ma ka ho'omalo'o <731>: E ho'omalo'o i kahi la'ana ma 105 ℃ no 3 h: nalowale NMT 0.5% o kona kaumaha.
NA KOI HOU
• Hoʻopaʻa a me ka mālama ʻana: E mālama i loko o nā pahu paʻa, a e mālama i kahi mahana wela.
• Lepili: Inā hoʻohana ʻia kahi hoʻāʻo no nā Organic Impurities e HPLC ʻē aʻe ma mua o ke Kaʻina Hana 1, a laila hōʻike ka lepili i ka hoʻāʻo e hoʻokō ai ka ʻatikala.
• Nā Kūlana Kūlana USP <11>

USP Carvedilol RS
USP Carvedilol Puhui Pili A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74
USP Carvedilol Puhui Pili B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74
USP Carvedilol Puhui Pili C RS
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60
USP Carvedilol Puhui Pili D RS
4-(Oxiran-2-ylmethoxy)-9H-carbazole.
C15H13NO2 239.27
USP Carvedilol Puhui Pili E RS
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21
USP Carvedilol Pūnaehana Kuleana Mixture RS
Ka hui pū ʻana o 0.1% carvedilol pili pūhui F (1-(2-(2-Methoxyphenoxy)ethylamino)-3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) i loko o kahi matrix o carvedilol lāʻau lāʻau.
E kākau i kāu leka ma aneʻi a hoʻouna mai iā mākou