Carvedilol Phosphate Hemihydrate CAS 610309-89-2 Maʻemaʻe >99.0% (HPLC)

ʻO Carvedilol Phosphate Hemihydrate (CAS: 610309-89-2) he mea koho koho α1-receptor a me ka mea koho ʻole β-receptor blocker, ʻaʻohe intrinsic Sympathimetic active drugs, bioavailability o 10 ~ 47%, ʻaʻole pili i ka meaʻai, ka hopena ma α1 ʻOi aku ka haʻahaʻa o ka receptor ma mua o ka β1-a me ka β2-receptor, ʻo ka lākiō ikaika o β 1-a me β2-receptor blockade ʻo 1:10 ~ 1:100.ʻO ka hopena o ka β 1-receptor blockade ma kahi o 1/2 o labetalol, a ʻoi aku ka nāwaliwali o kāna α1 blockade ma mua o prazosin.Hiki iā ia ke hoʻomāhuahua i nā kīʻaha koko, e hoʻemi i ka pale ʻana i nā ʻāpana āpau, hoʻomāhuahua i nā kīʻaha coronary a me ka renal, a hoʻemi i ke kaomi pulmonary wedge.Loaʻa iā ia ka hopena palekana i ka myocardial hypoxia a me ka hōʻeha myocardial i hoʻokumu ʻia e ka myocardial infarction, hiki ke pili i ka pale ʻana i ka β-receptor, hiki ke hōʻemi i ka emi ʻana o ka myocardial glycogen a me ka piʻi ʻana o ka pH, a hoʻemi i ka nui infarct.
Hoʻohana ʻia ʻo Carvedilol Phosphate Hemihydrate no ka mālama ʻana i ka hypertension me ka haʻahaʻa a hiki ke hoʻohana wale ʻia a i hui pū ʻia me nā lāʻau antihypertensive ʻē aʻe (ʻoi aku ka thiazide diuretics).No ka hōʻailona maʻi congestive naʻau hāʻule.
ʻO Carvedilol Phosphate Hemihydrate kahi mea koho β/α-1 receptor blocker.Kāohi ʻo Carvedilol i ka lipid peroxidation me kahi IC50 o 5 μM.ʻO Carvedilol kahi lāʻau antihypertensive multi-purpose me ka hiki ke aʻo i ka angina pectoris a me ka puʻuwai congestive.