Risperidone CAS 106266-06-2 Hōʻike 98.0~102.0%
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o Risperidone (CAS: 106266-06-2) me ke kūlana kiʻekiʻe.Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.Kūʻai iā Risperidone,Please contact: alvin@ruifuchem.com
| Inoa Kimia | Risperidone |
| Nā huaʻōlelo like | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a] pyrimidin-4-hoʻokahi;Risperdal;Risperdal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 106266-06-2 |
| ʻĀpana Molekala | C23H27FN4O2 |
| Kaumaha Molecular | 410.49 g/mol |
| Lae hehee | 170.0 a 174.0 ℃ |
| ʻO ka mānoanoa | 1.38±0.10 g/cm3 |
| Papa Hazard | 6.1;ʻawaʻawa |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Brand | Kemika Ruifu |
| Nā mea | Nā kikoʻī | Nā hualoaʻa |
| Ka nana aku | Keʻokeʻo a hiki i ka pauda keʻokeʻo | Hoʻokō |
| ʻIkepili A | Infrared Absorption | Hoʻokō |
| ʻIkepili B | Manawa Paʻa: E pili ana i ka mea kuhikuhi | Hoʻokō |
| Nalo ma ka maloo | <0.50% | 0.12% |
| Koena ma ka Ignition | <0.10% | 0.07% |
| Nā Metala Kaumaha | <0.001% | <0.001% |
| Puhui Pili | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| ʻO ka haumia ʻike ʻole ʻia | <0.10% | <0.10% |
| Huina paumaele | <0.30% | <0.30% |
| Hoʻāʻo | 98.0~102.0% (I helu ʻia ma ke kumu maloʻo) | 100.52% |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō me ka USP 35 Standard | |
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a] pyrimidin-4-one [106266-06-2].
» Aia ka Risperidone ma lalo o 98.0 pākēneka a ʻaʻole ʻoi aku ma mua o 102.0 pākēneka o C23H27FN4O2, i helu ʻia ma ke kumu maloʻo.
Hoʻopaʻa ʻia a mālama ʻia - mālama i loko o nā pahu paʻa maikaʻi.E mālama i ka lumi wela.
Nā kūlana hōʻike USP <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a] pyrimidin-4-one 410.48 CAS-106266-06-2
USP Risperidone Pūnaehana Hui Pūnaehana Pono RS
Loaʻa i ka risperidone a ma kahi o 0.2% o kēlā me kēia o kēia:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-hoʻokahi.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-hoʻokahi.
[Note-He risperidone kēia hui ʻana, Z-oxime, 9-hydroxyrisperidone, a me 6-methylrisperidone.]
ʻike-
A: Infrared Absorption <197K>.
B: ʻO ka manawa paʻa o ka piko nui ma ka chromatogram o ka hoʻomākaukau Assay e pili ana i kēlā i loko o ka chromatogram o ka hoʻomākaukau maʻamau, e like me ka loaʻa ʻana ma ka Assay.
Nalo ma ka maloo <731>- Maloo i ka momi ma 80 no 4 mau hora: aole e oi aku mamua o 0.5% o kona kaumaha.
ʻO ke koena ma ka ʻā ʻana <281>: ʻaʻole i ʻoi aku ma mua o 0.1%, hoʻohana ʻia kahi mea hoʻāʻo 2.0-g.
Nā metala kaumaha, Keʻano II <231>: 0.001%.
Huipuia pili-
ʻO ka hopena Buffer, Solution A, Solution B, Mobile phase, Diluent, System suitability solution, a me Chromatographic system-E hoʻomākaukau e like me ke kuhikuhi ʻana i ka Assay.
Hoʻonā maʻamau-E hoʻohana i ka hoʻomākaukau maʻamau, i hoʻomākaukau ʻia e like me ke kuhikuhi ʻana i ka Assay.
Hoʻoholo hoʻāʻo-E hoʻohana i ka hoʻomākaukau Assay.
Ke Kaʻina Hana-E hoʻokomo i nā puke like (e pili ana i 10 µL) o ka solution Standard a me ka solution Test i loko o ka chromatograph, a hoʻopaʻa i ka chromatogram.E ʻike i nā haumia me ka hoʻohana ʻana i nā manawa paʻa pili i hāʻawi ʻia ma ka Papa 1, a e ana i nā pane kiʻekiʻe.E helu i ka pākēneka o kēlā me kēia pūhui pili risperidone ma ka ʻāpana o Risperidone i lawe ʻia e ke kumu:
100(CS /CU)(rU / rS)(1/F)
i loko o ka CS a me ka CU nā hoʻopaʻa ʻana, ma ka mg no ka mL, o risperidone i loko o ka hoʻonā maʻamau a me ka hopena hoʻāʻo;ʻO rU ka wahi kiʻekiʻe o kēlā me kēia haumia i loaʻa mai ka hoʻonā Ho'āʻo;ʻO rS ka ʻāpana kiʻekiʻe o risperidone i loaʻa mai ka hopena maʻamau;a ʻo F ka mea pane pili no kēlā me kēia haumia e pili ana i risperidone.Ma waho aʻe o nā palena ma ka Papa 1, ʻaʻole i ʻoi aku ma mua o 0.10% o nā haumia ʻike ʻole (hoʻohana i ka waiwai F o 1.0) ʻike ʻia a ʻaʻole i ʻoi aku ma mua o 0.30% o ka nui o nā haumia i loaʻa.E haʻalele i nā kiʻekiʻe haumia i emi iho ma mua o 0.05%.
Papa 1
Hoʻopaʻa manawa paʻa pili pūhui pili (RRT) kumu pane pili (F) palena (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-hoʻokahi
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-hoʻokahi
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-hoʻokahi
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
hoʻāʻo-
Hoʻoheheʻe Buffer- E hoʻoheheʻe i 15.4 g o ka ammonium acetate i 1 L o ka wai.Hoʻoponopono me 10% acetic acid i kahi pH o 6.5, a hui pū.
Pane A-E hoʻohui i 100 mL o ka solution Buffer me 150 mL o ka methanol i loko o ka pahu volumetric 1000-mL, a hoʻoheheʻe ʻia me ka wai i ka nui.
Pane B- E hoʻohui i 100 mL o ka solution Buffer me 850 mL o ka methanol i loko o ka pahu volumetric 1000-mL, a hoʻoheheʻe ʻia me ka wai i ka nui.
ʻĀpana paʻalima-E hoʻohana i nā hui like ʻole o ka Solution A a me ka Solution B e like me ke kuhikuhi ʻana no ka ʻōnaehana Chromatographic.Hana i nā hoʻololi inā pono (e nānā i ka System Suitability ma lalo o Chromatography 621).
Diluent-Mix 100 mL o ka hopena Buffer me 900 mL o ka wai a me 1000 mL o ka methanol.
ʻO ka hoʻonā kūpono o ka ʻōnaehana-E hoʻomākaukau i kahi hopena 1 mg no ka mL o ka USP Risperidone System Suitability Mixture RS i Diluent.
Hoʻomākaukau maʻamau-E hoʻoheheʻe i ka nui i kaupaona pono ʻia o USP Risperidone RS i ka Diluent, a dilute quantitatively, a me ka stepwise inā pono, me ka Diluent e loaʻa ai kahi hopena i ʻike ʻia ma kahi o 1.0 mg no mL.
Hoʻomākaukau hoʻāʻo-E hoʻoheheʻe i ka nui o Risperidone i kaupaona pono ʻia i ka Diluent, a dilute quantitatively, a stepwise inā pono, me ka Diluent e loaʻa ai kahi hopena i loaʻa ka ʻike o kahi 1.0 mg no mL.
Pūnaehana Chromatographic (e nānā i ka Chromatography <621>)- Ua lako ka chromatograph wai me kahi mea ʻike 275-nm a me kahi kolamu 4.6-mm × 10-cm i loaʻa iā 3-µm packing L1.ʻO ka nui o ke kahe ʻana he 1.5 mL i kēlā me kēia minuke.Mālama ʻia ka mahana o ke kolamu ma 35. Hoʻonohonoho ʻia ka chromatograph penei.
Manawa (minuke) Hoʻonā A (%) Haʻina B (%) Elution
0–1 70 30 hoʻokalakupua
1–20 70®5 30®95 kaha kaha laina
20–25 5 95 hoʻokalakupua
25–27 5®70 95®30 kaha kaha laina
27–35 70 30 hoʻolike hou E hoʻokomo i ka ʻōnaehana kūpono.E hoʻopaʻa i nā pane kiʻekiʻe e like me ke kuhikuhi ʻana no ke Kaʻina hana, a e ʻike i nā piko ma muli o Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, a me risperidone me ka hoʻohana ʻana i nā manawa paʻa pili (RRT) mai ka Papa 1;ʻo ka hoʻonā, R, ma waena o Z-oxime a me 9-hydroxyrisperidone ʻaʻole i emi iho ma mua o 2.8;ʻaʻole iʻoi aku ka nui o ka huelo no risperidone ma mua o 1.5;a ʻaʻole ʻoi aku ka ʻokoʻa maʻamau pili no ka hoʻopiʻi hou ʻana ma mua o 2.0% no ka piko risperidone.
Kaʻina hana- E hoʻokaʻawale i nā puke like (ma kahi o 10 µL) o ka hoʻomākaukau maʻamau a me ka hoʻomākaukau ʻana i ka Assay i loko o ka chromatograph, a ana i nā pane no ka piko risperidone.E helu i ka nui, ma ka pakeneka o C23H27FN4O2, ma ka mahele o Risperidone i laweia e ke kumu:
100(CS /CU)(rU / rS)
i loko o ka CS a me ka CU ka hoʻopaʻa ʻana, i mg per mL, o risperidone i ka hoʻomākaukau maʻamau a me ka hoʻomākaukau Assay, kēlā me kēia;a ʻo rU a me rS nā pane kiʻekiʻe i loaʻa mai ka hoʻomākaukau Assay a me ka hoʻomākaukau maʻamau.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Nā Code Risk R25 - He mea ʻawaʻawa ke ale ʻia
R23/24/25 - He mea ʻona ma ka inhalation, pili me ka ʻili a inā ale ʻia.
R11 - Hiki ke ahi
ʻO ka wehewehe palekana S28 - Ma hope o ka hoʻopili ʻana me ka ʻili, holoi koke me ka nui o ke kopa.
S36 - E hoʻohana i nā lole pale kūpono.
S45 - Inā loaʻa ka pōʻino a i ʻole ka maikaʻi ʻole, e ʻimi koke i ka ʻōlelo aʻo kino (e hōʻike i ka lepili inā hiki.)
S36/37 - E hoʻohana i nā lole pale kūpono a me nā mīkina lima.
S16 - E hoʻokaʻawale i nā kumu o ke ahi.
UN ID 3249
WGK Kelemānia 3
RTECS UV1164800
HS Code 2934999099
Papa Hazard 6.1(a)
Hui Pūʻulu II
ʻO Risperidone (CAS: 106266-06-2) he hopena antagonism ma nā mea loaʻa 5HT2 a me nā mea loaʻa D2.Hoʻohana ʻia ʻo Risperidone no ka schizophrenia maʻi a maʻi.Nā lāʻau antipsychotic.Hoʻohana ʻia ʻo Risperidone no ka mālama ʻana i ka schizophrenia maʻi a me ka maʻi maʻi a me nā ʻano psychotic ʻē aʻe i ʻike ʻia nā hōʻailona maikaʻi (e like me ka hallucinations, illusions, noʻonoʻo ʻino, huhū, kānalua) a me nā hōʻailona maikaʻi ʻole (e like me ka pane ʻole, ka manaʻo ʻole a me ka manaʻo ʻole o ka lehulehu. huaʻōlelo).Hiki iā ia ke ho'ēmi i nā hōʻailona pili i ka schizophrenia (e like me: ke kaumaha, ka hewa, ka hopohopo).No nā poʻe maʻi i kūpono i ka Risperidone no ka mālama koʻikoʻi, i ka manawa mālama o ka mālama ʻana, hiki i ka Risperidone ke hoʻomau i ka pāʻani i kona pono lapaʻau.No laila, he hana lapa'au 'o Risperidone ma nā hō'ailona maika'i a me nā hō'ailona maika'i 'ole o ka schizophrenia a ho'ohua mai i ka li'ili'i loa o nā hopena 'ao'ao ma kahi o nā hō'ailona extrapyramidal i ho'ohālikelike 'ia me D2 antagonist antipsychotics ma'ema'e.Loaʻa iā ia ka mana no ka hoʻokele ʻana i ka wehe ʻana i ka waiʻona a me ka addiction cocaine.
