2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Intermediate Maʻemaʻe >99.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o 2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) me ke kūlana kiʻekiʻe, waena o Perampanel (CAS: 380917-97-5).Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku i nā mea waena Perampanel, Please contact: alvin@ruifuchem.com
| Inoa Kimia | 2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Nā huaʻōlelo like | 2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2-(1,3,2-Dioxaborinan-2-yl)benzonitrile |
| Helu CAS | 172732-52-4 |
| Kūlana Kūʻai | Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona |
| ʻĀpana Molekala | C10H10BNO2 |
| Kaumaha Molecular | 187.01 |
| Lae hehee | 46.0~51.0℃ (māmā) |
| ʻO ka mānoanoa | 1.13±0.10 g/cm3 |
| Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka Methanol |
| Paʻa | Hygroscopic |
| Brand | Kemika Ruifu |
| 'ikamu | Nā kikoʻī |
| Ka nana aku | Keʻokeʻo i ka ʻulaʻula Melemele ʻulaʻula i ka Crystal |
| Maʻemaʻe / Kaʻina Hanana | >99.0% (HPLC) |
| Nalo ma ka maloo | <0.50% |
| Koena ma ka Ignition | <0.20% |
| Hoʻokahi haumia | <0.50% |
| Huina paumaele | <1.00% |
| Nā Metala Kaumaha (e like me Pb) | <20ppm |
| Kūlana hoʻāʻo | ʻOihana Kūlana |
| Hoʻohana | Kūwaena o Perampanel (CAS: 380917-97-5) |
Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.
Nā hōʻailona pōʻino Xi - Hoʻonāukiuki
Nā Code Risk
R20/21/22 - He pōʻino ma ka inhalation, pili me ka ʻili a inā ale ʻia.
R36/37/38 - E hoʻonāukiuki i nā maka, ka ʻōpū hanu a me ka ʻili.
Ka wehewehe palekana
S26 - Inā pili me nā maka, e holoi koke me ka wai nui a e ʻimi i ka ʻōlelo aʻo kino.
S36/37/39 - E hoʻohana i nā lole pale kūpono, nā mīkina lima a me ka pale maka/maka.
UN ID 3439
WGK Kelemānia 3
TSCA No
Nānā Hazard He mea hoʻonāukiuki
Hoʻohana ʻia ʻo 2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) i ka synthesis o Perampanel (CAS: 380917-97-5), he mea kūʻē i ka AMPA receptor antagonist.ʻO Perampanel (laikini ʻia i ka makahiki 2012) ʻo ia ke kolu o ka hanauna AED i ʻike ʻia me ka inoa brand proprietary o Fycompa® (Eisai, Hatfield) ma UK a me Banzel® (Eisai, Hatfield) ma USA.I ʻOkakopa 2012, ua ʻae ka US FDA i ka perampanel no ka mālama ʻana i nā maʻi epileptic ma lalo o 12 mau makahiki.ʻO Perampanel ka mua AMPA receptor antagonist e loaʻa ka ʻae FDA ma ke ʻano he AED.Loaʻa ka AMPA glutamate receptors ma luna o nā neurons postsynaptic i ka lolo.Ma ke ʻano he antagonist koho, noncompetitive o AMPA, pale ka parampanel i ka wehe ʻana o ke kahawai ion a hōʻemi i ka hoʻolaha ʻana o ka hiki ke hana.Ua ʻae ʻia ʻo Perampanel e ka European EMA a me US FDA i Iulai a me ʻOkakopa 2012, ua hoʻohana ʻia no ka mālama adjuvant o nā maʻi me ka hopu ʻana i ka hapa ma mua o 12 mau makahiki me ka ʻole o ka hoʻopaʻapaʻa ʻōnaehana lua.Ma ka lā 22 o Iune, 2015, ua hoʻolaha ʻo Eisai ua ʻae ka US FDA i ka hoʻonui ʻana i ka hōʻailona o Pirenparanide hydrate (Fycompa) ma ke ʻano he lāʻau lapaʻau no ka hoʻopaʻa ʻana i ka tonic-clonic mua loa i nā maʻi me ka epilepsy makahiki 12 a ma luna.
