CAS 177036-94-1 Maʻemaʻe >99.0% (HPLC) API Hale Hana Maʻemaʻe Kiʻekiʻe

(CAS: 177036-94-1) APIhe endothelin-A (ETA) receptor antagonist i hoʻokomo ʻia no ka mālama waha ʻana i nā maʻi me ka pulmonary arterial hypertension (PAH), e hoʻomaikaʻi i ka hiki ke hoʻoikaika a hoʻopaneʻe i ka hoʻonui ʻana i ke kino.ʻO ka PAH he maʻi kakaʻikahi o nā aʻaʻaʻa liʻiliʻi liʻiliʻi i hōʻike ʻia e ka hoʻonui ʻana a me ka hoʻoponopono hou ʻana, e hopena i ka piʻi ʻana o ke kūpaʻa ʻana o ka pulmonary vascular a me ke kaomi ʻana o ka pulmonary arterial, a ʻo ka hopena, ʻaʻole hiki i ka ventricular akau a me ka make mua.ʻO nā hōʻailona mua o ka PAH e pili ana i ka hoʻomaka mālie o ka hanu, ka luhi, ka palpitation, ka edema, a me ka maule.ʻO Endothelin-1 (ET-1), he vasoconstrictor ikaika a me ka mitogen muscle maʻemaʻe, he mea kōkua nui i ka wikiwiki o ka maʻi, a ua hoʻopili ʻia kona hopena ma o ka hoʻāla ʻana o nā mea loaʻa ETA a me ETB.I Iune o 2007, ua hāʻawi ka FDA i ka ʻae ʻia (CAS: 177036-94-1) API no ka mālama ʻana i hoʻokahi lā i ka PAH.