Lapatinib Base CAS 231277-92-2 Maʻemaʻe ≥99.0% (HPLC)

ʻO ka wehewehe pōkole:

Inoa Kimia:Lapatinib Base

CAS: 231277-92-2

Maʻemaʻe: ≥99.5% (HPLC)

Kokoke keʻokeʻo a i ʻole ka ʻulaʻula melemele Crystalline pauda

Hoʻokaʻaʻike: Kauka Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Nā Huahana Pili

Huahana Huahana

Lapatinib Intermediates:

Lapatinib Base	CAS 231277-92-2
ʻO Lapatinib Ditosylate Monohydrate	CAS 388082-78-8
Sodium Methanesulfinate	CAS 20277-69-4
3-Chloro-4-(3-Fluorobenzyloxy)aniline	CAS 202197-26-0
2-Aminoethyl Methyl Sulfone Hydrochloride	CAS 104458-24-4
4-Chloro-6-Iodoquinazoline	CAS 98556-31-1
6-Iodo-4-Hydroxyquinazoline	CAS 16064-08-7
5-Formyl-2-Furanboronic Acid	CAS 27329-70-0
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	CAS 231278-84-5

Na Waiwai Kemika:

Inoa Kimia	Lapatinib Base
Nā huaʻōlelo like	Lapatinib;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[(2-(methylsulfonyl)ethyl]amino]methyl]furan-2-yl]quinazolin-4-amine N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
Helu CAS	231277-92-2
Kūlana Kūʻai	Loaʻa
ʻĀpana Molekala	C29H26ClFN4O4S
Kaumaha Molecular	581.06
Lae hehee	141.0~149.0 ℃
ʻO ka mānoanoa	1.381±0.06 g/cm3
COA & MSDS	Loaʻa
Brand	Kemika Ruifu

Nā kikoʻī:

'ikamu	Nā kikoʻī
Ka nana aku	Kokoke keʻokeʻo a i ʻole ka ʻulaʻula melemele Crystalline pauda
ʻIkepili	IR;HPLC
Maʻemaʻe / Kaʻina Hanana	≥99.0% (HPLC)
Lae hehee	141.0~149.0 ℃
Nalo ma ka maloo	≤0.50%
Koena ma ka Ignition	≤0.10%
Nā Metala Kaumaha (e like me Pb)	≤20ppm
ʻO nā mea haumia kino	E hoʻokō i ke koi
Na mea pili
Hoʻokahi haumia	≤0.30%
Huina paumaele	≤1.00%
Kūlana hoʻāʻo	Kūlana ʻoihana
Ola Pahu	2 makahiki i ka mālama pono ʻana
Hoʻohana	API, He lapaau waha no ka ma'i ma'i ma'i

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻOmole, ʻeke ʻeke Aluminum, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai

Pono:

FAQ:

231277-92-2 - Noi:

API (CAS: 231277-92-2)he lāʻau lapaʻau i manaʻo ʻia no ka lāʻau maʻi maʻi umauma, he mea hoʻopaneʻe tyrosine kinase, hiki ke pale pono i ka hana o ka epidermal growth factor receptor -1 (ErbB1) a me ke kanaka epidermal growth factor receptor (ErbB2) tyrosine kinase hana o -2.He mea kū hoʻokahi ia i hiki ke pāʻani i kahi hana ma nā ʻano like ʻole, i hiki ʻole ai i nā pūnaʻi maʻi maʻi umauma ke loaʻa ka hōʻailona e pono ai no ka ulu ʻana.ʻO ka hana o ka hana ke kāohi i ka intracellular EGFR (ErbB-1) a me HER2 (ErbB-2) ATP pūnaewele e pale ai i ka phosphorylation a me ka hoʻoulu ʻana o nā pūnae tumora, a me ka pale ʻana i ka hoʻoponopono iho o ka hōʻailona e EGFR (ErbB-1) a ʻO HER2 (ErbB-1) like ʻole a me ka heterogeneous ʻelua aggregates.Hoʻohana ʻia ka hui pū ʻana o (CAS: 231277-92-2) me Capecitabine no ka mālama ʻana i nā maʻi me ka maʻi maʻi a i ʻole metastatic o ka umauma me ka overexpression o ka epidermal receptor2 kanaka, ua mālama ʻia me nā anthracyclines, paclitaxel, a me trastuzumab.Ua hōʻike ʻia nā hoʻokolohua lapaʻau i ka mālama pono ʻana i nā maʻi maʻi maʻi maʻi ʻano HER2 me ka pale ʻana iā Herceptin.

231277-92-2 - Nā hōʻailona:

ʻO Lapatinib i hui pū ʻia me Capecitabine he mea kūpono ia no ka mālama ʻana i nā maʻi maʻi maʻi maʻi maʻi maʻi a i ʻole metastatic me HER2 (ErbB-2 overexpression) a me ka mālama mua ʻana me nā anthracyclines, paclitaxel a me trastuzumab.

231277-92-2 - Pilikino Laʻau:

Hiki i nā papa Lapatinib in vitro ke kāohi i ka CYP3A4 a me CYP2C8 i nā ʻano therapeutic, a ua hoʻololi nui ʻia e CYP3A4.ʻO nā lāʻau lapaʻau e kāohi ana i kēia hana enzyme hiki ke hoʻonui nui i ka nui o ka lāʻau lapaʻau koko o Lapatinib.Ketoconazole, 0.2g i kēlā me kēia manawa, 2 manawa/d, hiki ke hoʻonui i ka AUC o Lapatinib e 3-7 mau manawa a hoʻolōʻihi i ka hapalua o ke ola ma 1.7 mau manawa ma hope o 7 mau lā.Lawe nā mea manawaleʻa olakino i ka CYP3A4 inducer ma ka waha, 100 mg i kēlā me kēia manawa, ʻelua i ka lā, a hoʻololi ʻia i 200mg i kēlā me kēia manawa ma hope o nā lā 3, e kaʻana like i nā lā 17 ʻelua i ka lā.Ua emi iho ka AUC o Lapatinib e 72%.ʻO Lapatinib kahi kahua halihali no ka P-glycoprotein, a ʻo nā lāʻau lapaʻau e kāohi i ka glycoprotein hiki ke hoʻonui i ke koko o ka lāʻau.

Laau Laau Laau Hou no ka Lapaau Hoopalauia o ka Ma'i Kano.

He lāʻau lapaʻau hou ʻo Lapatinib no ka maʻi maʻi umauma i hoʻomohala ʻia e GlaxoSmithKline, UK.ʻO ia ka tyrosine kinase inhibitor e hiki ke pale pono i ke kanaka epidermal growth factor receptor -1(ErbB1) a me ke kanaka epidermal growth factor receptor -2(ErbB2) tyrosine kinase.He mea kū hoʻokahi ia i hiki ke hana i nā ʻano like ʻole i hiki ʻole i nā pūnaʻi maʻi maʻi umauma ke loaʻa nā hōʻailona e pono ai no ka ulu ʻana.ʻO ka hana o ka hana ke kāohi i nā pūnaewele ATP o EGFR (ErbB-1) a me HER2 (ErbB-2) i loko o nā cell e pale ai i ka phosphorylation a me ka hoʻāla ʻana o nā pūnaewele tumo, a kāpae i nā hōʻailona hoʻoponopono ma o nā dimer homogenous a heterogeneous o EGFR (ErbB. -1) a me HER2(ErbB-1).ʻO ka molecular targeted therapy no ka maʻi maʻi umauma e pili ana i ka mālama ʻana i nā oncogenes a me nā huahana hōʻike pili e pili ana i ka hanana a me ka ulu ʻana o ka maʻi maʻi umauma.ʻO nā lāʻau lapaʻau i hoʻopaʻa ʻia i ka molecular ke kāohi a pepehi i nā pūnaewele tumo ma ke kāohi ʻana i ka lawe ʻana i ka hōʻailona i loko o nā pūnaewele a i ʻole nā pūnaewele pili e hoʻomalu i nā loli i ka hōʻike ʻana o ke ʻano.Ma Malaki 14, 2007, ua ʻae ka US meaʻai a me ka hoʻokele lāʻau i ka hui pū ʻana o lapatinib a me xeloda (capecitabine) no ka mālama ʻana i nā maʻi maʻi maʻi maʻi maʻi maʻi a i ʻole metastatic overexpressed e kanaka epidermal factor receptor 2 (ErbB2) a mālama ʻia me nā anthracyclines, paclitaxel a me trastuzumab .Hōʻike nā hoʻokolohua lapaʻau he hopena maikaʻi nō hoʻi kēia huahana no nā poʻe maʻi maʻi maʻi umauma HER2 i hoʻomohala i ka lāʻau kūʻē iā Roche's Herceptin (Herceptin).ʻO lapatinib kahi lāʻau anticancer hou.Hiki iā ia ke hana i nā pahuhopu Her-1 a me Her-2 i ka manawa like.ʻOi aku ka nui o ka hopena olaola o kēia ʻano hana i ka hoʻonui ʻana a me ka ulu ʻana o nā cell tumor ma mua o hoʻokahi pahuhopu.ʻO nā lāʻau lapaʻau i kapa ʻia e pili ana i nā lāʻau lapaʻau e hoʻohana ana i kekahi mau mea loaʻa, nā genes a i ʻole nā proteina koʻikoʻi e like me nā pahuhopu e pepehi ai i nā cell tumor pili i ke ʻano i kuhikuhi ʻia.