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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Maʻemaʻe ≥99.0% (HPLC)
ʻO Ruifu Chemical ka mea hoʻolako alakaʻi o Ethyl Chloro [(4-Methoxyphenyl)hydrazono] acetate (CAS: 27143-07-3) me ke kūlana kiʻekiʻe, waena o Apixaban (CAS: 503612-47-3).Hiki iā Ruifu ke hāʻawi i ka hāʻawi honua, ke kumukūʻai hoʻokūkū, nā mea liʻiliʻi a me ka nui.E kūʻai i nā kikowaena Apixaban, E-mail: alvin@ruifuchem.com
| Inoa Kimia | Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Nā huaʻōlelo like | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;ʻO ka haumia ʻo Apixaban 3 |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 27143-07-3 |
| ʻĀpana Molekala | C11H13ClN2O3 |
| Kaumaha Molecular | 256.69 g/mol |
| Lae hehee | 94 ℃ |
| ʻO ka mānoanoa | 1.23 |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Māhele | Kūwaena o Apixaban (CAS: 503612-47-3) |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Melemele māmā i ka pauda melemele | Hoʻokō |
| Nalo ma ka maloo | <0.50% | 0.23% |
| Maʻemaʻe / Kaʻina Hanana | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
| 1 H NMR Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō i nā kikoʻī i hāʻawi ʻia | |
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
Ka papa inoa o nā mea hoʻoheheʻe i hoʻohana ʻia i ka hana ʻana
| ʻAʻole. | Inoa | CAS No. | ʻĀpana Molekala |
| 1 | Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Ethyl Alcohol | CAS: 64-17-5 | C2H5OH |
5.3.1 Nānā: Pono ia he melemele māmā a i ka pauda melemele.I ka nana aku, e waiho i ka nui o ka mea hoao (me ke kaupaona ole) iloko o ka ipu aniani maemae ma ke kua keokeo (e like me ka pepa keokeo) malalo o ka malamalama maoli.
5.3.2 Identification: 1H-NMR ua like ke ano o ka ma'amau.10 ~ 15mg o ka hāpana ua kaupaonaʻia i loko o ka nuklea magnetic paipu, a me 0.5mL o deuterium DMSO i hoʻohuiʻia e hoʻopau piha i ka hāpana, a laila ho'āʻoʻia me kahi mea kani hoʻoheheʻe nukili ma mua o 400MHz.
5.3.3 Pohō ma ka maloʻo : E kaupaona i ka hāpana ma kahi o 1.0g a maloʻo no 3h i loko o ka umu maloʻo ma 85 ℃.ʻO ka hana kūikawā no ka helu ʻana i ke kaumaha e hana ʻia e like me nā ʻōlelo o SOP-AP-QC-002-01 no ka hoʻoholo ʻana i ka hoʻomaloʻo ʻana i ke kaumaha.
5.3.4.1 Nā kūlana Chromatographic:
Nā mea ho'āʻo ho'āʻo: 1) acetonitrile no ka chromatography 2) wai hoʻomaʻemaʻe 3) phosphoric acid
Kona: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
ʻĀpana kelepona: A: Ana pololei i ka 1.0ml phosphoric acid a me 1000ml wai, kānana ultrasonic degassing.
B: Acetonitrile.
ʻO ke kaʻina hana gradient: ka papa ma lalo nei
Māhele paʻa lima A (%) Māhele paʻalima B (%)
3 90 10
10 25 75
20 0 100
25 0 100
ʻIke: 210nm
Ka wela o ke kolamu: 35 ℃
Ka māmā holo: 1.0ml / min
Laʻana nui: 5µl
5.3.4.2 Hoʻomākaukau hoʻonā:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Haʻina hakahaka: e hoʻohana ʻia ka mea hoʻoheheʻe ma ke ʻano he haʻina hakahaka.
5.3.4.5 Ho'āʻo huahana hoʻonā: E kaupaona i ka huahana ho'āʻo e pili ana i 12.5mg i loko o ka 25ml volumetric omole a hoʻoheheʻe me ka diluent i ka unahi.
5.3.4.6 Ke kaʻina hana: Ma hope o ka paʻa ʻana o ka pae kumu o ka mea kani, hoʻokahi a ʻelua mau injections o ka hāʻina hakahaka, a laila ʻike ʻia ka hopena o ka huahana hoʻāʻo.Mālama ʻia ka chromatogram a hoʻopaʻa ʻia, wehe ʻia ka piko blank, a ʻo ka hopena maʻemaʻe a me nā hopena haumia hoʻokahi ma ka chromatogram o ka huahana hoʻāʻo e hoʻopaʻa ʻia e ke ʻano maʻamau.Ma hope o ka nānā ʻana, paʻi ʻia ka chromatogram.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
Mākeke Nui?E kūʻai aku i ka mākeke kūloko, ʻAmelika ʻĀkau, ʻEulopa, India, Korea, Iapana, Australia, etc.
Nā pono?ʻO ke kūlana kiʻekiʻe, ke kumukūʻai kūpono, nā lawelawe ʻoihana a me ke kākoʻo ʻenehana, ka lawe wikiwiki ʻana.
ʻAno maikaʻiHōʻoiaʻiʻo?Pūnaehana hoʻomalu maikaʻi koʻikoʻi.ʻO nā lako ʻoihana no ka nānā ʻana ʻo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.
Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
MOQ?ʻAʻohe MOQ.ʻAe ʻia ke kauoha liʻiliʻi.
Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.
Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.
Nā palapala?Ma hope o ka lawelawe kūʻai: COA, MOA, ROS, MSDS, etc.
Hoʻohui Kuʻuna?Hiki ke hāʻawi i nā lawelawe synthesis maʻamau e kūpono i kāu mau pono noiʻi.
Kūkākūkā uku?E hoʻouna mua ʻia ka invoice Proforma ma hope o ka hōʻoia ʻana o ke kauoha, hoʻopili ʻia kā mākou ʻike panakō.Uku e T/T (Telex Transfer), PayPal, Western Union, etc.
Hoʻohana ʻia ʻo Ethyl Chloro [(4-Methoxyphenyl)hydrazono] acetate (CAS: 27143-07-3) ma ke ʻano he waena i ka synthesis o Apixaban (CAS: 503612-47-3).ʻO Apixaban kahi ʻano hou o ka mea paʻa waha Xa i hoʻomohala pū ʻia e Bristol-Myers Squibb a me Pfizer.ʻO Erroto ka inoa kālepa.He ʻano hou o ka anticoagulant waha.Ma ke kāohi ʻana i kahi mea coagulation koʻikoʻi Xa, hiki i ka apixaban ke pale i ka hana thrombin a me ka thrombosis.Ua hoʻomohala ʻia ʻo Apixaban e Bristal-Myers squibb Company.Loaʻa iā ia ka bioavailability maikaʻi a me ke koho kiʻekiʻe.Ua heluʻia ma Kina i ka makahiki 2013. Ua palekanaʻo Apixaban, heʻuʻuku ka hiki ke pili i ka lāʻau lapaʻau, a he nui nāʻano e hoʻopau ai, i manaʻoʻia e hoʻohanaʻia i nā hui kūikawā e loaʻa ana i ka maʻi ate a iʻole ka pōʻino o ka hana kīkī.
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