1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one CAS 27387-31-1 Ondansetron HCl Dihydrate Maʻemaʻe Kūwaena >99.0% (HPLC)

Hoʻohana ʻia ka 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one (CAS: 27387-31-1) ma ke ʻano he waena o Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9).ʻO ka hoʻomohala ʻana o ka hui ʻo Glaxo United Kingdom, 1990 ma Farani, ka mākeke United Kingdom.ʻO ka huahana he serotonin koho nui loa (5-HT3) receptor antagonist, hiki ke kāohi i ka Nausea i hoʻokumu ʻia e ka chemotherapy a me ka radiotherapy Vomit, me ka ikaika kiʻekiʻe a me ke koho kiʻekiʻe, hiki ke hoʻomalu i ka ʻōpū liʻiliʻi a me nā mea loaʻa CTZ i hana ʻia e ka hoʻoulu ʻana o Vomit.He kūpono ia no ka mālama ʻana i ka Nausea Vomit i hoʻokumu ʻia e ka chemotherapy a me ka radiotherapy, a hiki ke hoʻohana ʻia no ka pale ʻana a me ka mālama ʻana i ka Nausea Vomit i hana ʻia ma hope o ka ʻoki ʻana.

ʻO Ondansetron, granisetron a me dolasetron ʻekolu mau lāʻau antiemetic i hoʻohana mau ʻia i loko o ke keʻena keʻena, ʻo ka ondansetron he mea ikaika, koho a hoʻihoʻi ʻia 5-hydroxytryptamine (5-HT3) receptor blocker no Alpha 1, Alpha 2, beta 1, Beta 2 adrenergic receptors a me histamine H1, He liʻiliʻi ka hopena o ka h2 receptor, a ʻaʻohe hopena antagonistic i ka H receptor, waena a me peripheral dopaminergic receptors, a hiki ke kāohi i ka Nausea a me ka Vomit i hoʻokumu ʻia e ka chemotherapy a me ka radiotherapy.Hoʻohālikelike ʻia me metoclopramide, ua ikaika ka hopena antiemetic a ʻaʻohe hopena extrapyramidal.ʻO Cisplatin, cyclophosphamide, doxorubicin i hoʻokumu ʻia e Vomit hiki ke hana i ka hopena anti-nausea wikiwiki a ikaika.He kūpono no ka mālama ʻana i nā lāʻau cytotoxic i hoʻokumu ʻia e ka chemotherapy a me ka radiation therapy Nausea Vomit, akā no ka pale ʻana a me ka mālama ʻana i ka Nausea Vomit i hoʻokumu ʻia e ka ʻoki.Hana ʻo ondansetron ma ke ʻano he wahi hoʻololi ma waena o nā aʻalolo visceral afferent i hoʻōla ʻia i ka ʻōpū o ka ʻōpū a me ka Vomit o nā kikowaena i loko o ke kuamoʻo, e hoʻoneʻe ai i ka neʻe ʻana o ka ʻōpū a me ka diaphragmatic.Hiki i nā lāʻau lapaʻau kemotherapy a me ka radiation therapy ke hoʻokuʻu i ka 5-HT i loko o ka ʻōpū liʻiliʻi, a ʻo ka Vomit reflex ke kumu o ka hoʻoulu ʻana o ke aʻalolo vagus ma o ka 5-HT3 receptor.Hoʻopaʻa kēia huahana i ka hanana ʻana o kēia reflex, ʻoiai ke kāohi nei i ka Vomit i hoʻokumu ʻia e ka hana kikowaena.ʻAʻole ʻike ʻia ke ʻano o ka hana no ka Nausea Vomit ma hope o ka ʻoki ʻana.Hiki i ka Ondansetron hui pū me ka dexamethasone ke hoʻonui i ka hopena antiemetic.