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Ibrutinib Intermediate CAS 330792-70-6 Maʻemaʻe >98.0% (HPLC) Kiʻi Hōʻike ʻia
  • Ibrutinib Intermediate CAS 330792-70-6 Maʻemaʻe >98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Maʻemaʻe >98.0% (HPLC)

ʻO ka wehewehe pōkole:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Maʻemaʻe: >98.0% (HPLC)

ʻAno: Keʻokeʻo-keʻokeʻo a i ka pauda Melemele Māmā

Kūwaena o Ibrutinib (CAS: 936563-96-1) 

Hoʻokaʻaʻike: Kauka Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Huahana Huahana

Nā Huahana Pili

Huahana Huahana

Nā mea waena o Ibrutinib:

Ibrutinib CAS 936563-96-1
3-Hydroxypiperidine CAS 6859-99-0
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo [3,4-d] pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8
ʻO ka Ibrutinib Deacrylylpiperidine CAS 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Na Waiwai Kemika:

Inoa Kimia 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Nā huaʻōlelo like Ibrutinib Intermediate N-3;3-Amino-5-(4-Phenoxyphenyl)pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5-(4-Phenoxyphenyl)pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Helu CAS 330792-70-6
Kūlana Kūʻai Ma ka waihona, ʻoi aku ka nui o ka hana a hiki i nā tona
ʻĀpana Molekala C16H12N4O
Kaumaha Molecular 276.29
ʻO ka mānoanoa 1.37±0.10 g/cm3
COA & MSDS Loaʻa
Ke kumu Shanghai, Kina
Brand Kemika Ruifu

Nā kikoʻī:

'ikamu Nā kikoʻī
Ka nana aku Pau-keʻokeʻo a i ka pauda Melemele Māmā
Maʻemaʻe / Kaʻina Hanana >98.0% (HPLC)
Nalo ma ka maloo <1.00%
Koena ma ka Ignition <0.50%
Huina paumaele <2.00%
Nā Metala Kaumaha (e like me Pb) <20ppm
1 H NMR Spectrum Kūlike me ka Hoʻolālā
Kūlana hoʻāʻo ʻOihana Kūlana
Hoʻohana Kūwaena o Ibrutinib (CAS: 936563-96-1)

Pūʻolo a me ka waiho ʻana:

Pūʻolo: ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.

Kūlana mālama:E mālama i loko o nā pahu i hoʻopaʻa ʻia ma kahi maloʻo a maloʻo;E pale i ka malamalama a me ka wai.

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330792-70-6 - Noi:

ʻO 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) he mea waena o Ibrutinib (CAS: 936563-96-1).Hōʻike ʻo Ibrutinib i ka hopena inhibitory potent a hiki ʻole ke hoʻololi ʻia a me ke koho no ka hana enzymatic Btk.Ma BCR ala-ho'ā 'ia DOHH2 cell laina, Ibrutinib inhibits autophosphorylation o Btk, phosphorylation o Btk's physiological substrate PLCγ, a me ka phosphorylation o lalo iho kinase, ERK me IC50 o 11 nM, 29 nM a me 13 nM, pakahi.Hōʻike ʻo Ibrutinib i ka nui o ka hoʻokomo ʻana o ka cytotoxicity i ka maʻi maʻi lymphocytic leukemia (CLL).Eia kekahi, hoʻoulu ʻo Ibrutinib i ka make cell ma muli o ka hoʻāla ʻana o ke ala caspase a hoʻohālikelike i ka hiki o nā cell CLL e hoʻonui ma hope o ka hōʻailona TLR.

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