5-(2-Pyridyl)-1,2-Dihydropyridin-2-one CAS 381233-78-9 Perampanel Ma'ema'e Waena >98.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o 5-(2-Pyridyl) -1,2-Dihydropyridin-2-one ([2,3'-Bipyridin] -6'(1'H) -one) (CAS: 381233-78-9) me ke kūlana kiʻekiʻe, waena o Perampanel (CAS: 380917-97-5).Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku i nā mea waena Perampanel,Please contact: alvin@ruifuchem.com
| Inoa Kimia | 5-(2-Pyridyl)-1,2-Dihydropyridin-2-one |
| Nā huaʻōlelo like | [2,3'-Bipyridin]-6'(1'H)-hoʻokahi;5-(Pyridin-2-yl)pyridin-2(1H)-hoʻokahi;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridin-2(1H)-hoʻokahi;5-Pyridin-2-yl-1H-Pyridin-2-one;5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-one;Ka haumia o Perampanel 1 |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 381233-78-9 |
| ʻĀpana Molekala | C10H8N2O |
| Kaumaha Molecular | 172.18 g/mol |
| Lae hehee | 71.0—75.0 ℃ |
| ʻO ka mānoanoa | 1.221±0.06 g/cm3 |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Māhele | Kūwaena o Perampanel (CAS: 380917-97-5) |
| Ola Pahu | 24 mau mahina inā mālama pono ʻia |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Keokeo a aneane keokeo pauda | Pauda keʻokeʻo |
| Maʻemaʻe / Kaʻina Hanana | >98.0% (HPLC) | 99.7% |
| Wai na Karl Fischer | <1.00% | 0.58% |
| Hoʻokahi haumia | <1.00% | Hoʻokō |
| Huina paumaele | <2.00% | 0.30% |
| 1H NMR Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō me nā kikoʻī i hāʻawi ʻia | |
| Palapala noi | Kūwaena o Perampanel (CAS: 380917-97-5) | |
Pūʻolo:ʻO ka ʻōmole Fluorinated, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a me ka makani maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
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Pono: Keʻokeʻo a kokoke i ka pauka keʻokeʻo
Solvent: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Etera, n-Hexane, Dichloromethane
E nānā: Nā mea e pili ana: E lawe i kēia huahana a hoʻoheheʻe ʻia me ka diluent (ka wai o ka pae kelepona: methanol (50∶50)) e hana i kahi hopena i loaʻa ma kahi o 0.5mg no 1ml ma ke ʻano he hopena huahana hoʻāʻo.Wahi a ka chromatography wai hana kiʻekiʻe (Chinese Pharmacopoeia 2010 Edition II Appendix Ⅴ D), ua hoʻohana ʻia ka silica gel (ZORBAX SB-C18 4.6 × 250mm,5m) i mea hoʻopiha.ʻO ka pae paʻa A he wai, ʻo ka māhele paʻa B he methanol, a ʻo 254nm ka lōʻihi hawewe ʻike.ʻO 1.0ml / min ke kahe kahe a ʻo ka mahana o ke kolamu he lumi wela.Ua ana pololei ʻia ka 5μl o ka hopena hoʻāʻo a hoʻokomo ʻia i loko o ka chromatograph wai e hoʻopaʻa i ka chromatogram.Wahi a ke kaʻina hana maʻamau, ʻaʻole emi ka ʻike o kēia huahana ma mua o 98%.Inā loaʻa nā piko haumia i ka chromatogram o ka hopena huahana hoʻāʻo, ʻaʻole ʻoi aku ka nui o ka wahi kiʻekiʻe o kēlā me kēia kanaka ma mua o 1.0%, a ʻaʻole e ʻoi aku ka nui o ka wahi kiʻekiʻe haumia ma mua o 2.0%.
Māmā: E lawe i kēia huahana, e hoʻohana i ka moisture tester, e like me ke ʻano o Karl Fischer (Chinese Pharmacopoeia 2010 edition II Appendix Ⅷ M mua ʻano A) hoʻoholo, ʻaʻole ʻoi aku ka nui o ka wai ma mua o 1.0%.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
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Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.
Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
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Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.
Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.
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5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-one) (CAS: 381233-78-9), he waena o Perampanel (CAS: 380917-97-5).ʻO Perampanel (laikini ʻia i ka makahiki 2012) ʻo ia ke kolu o ka hanauna AED i ʻike ʻia me ka inoa brand proprietary o Fycompa® (Eisai, Hatfield) ma UK a me Banzel® (Eisai, Hatfield) ma USA.Hoʻoponopono hoʻohui ʻia o ka hoʻopaʻa ʻana o ke alo me ka hoʻonui ʻana a i ʻole ka lua a me ka maʻi tonic-clonic generalized mua.I ʻOkakopa 2012, ua ʻae ka US FDA i ka perampanel no ka mālama ʻana i nā maʻi epileptic ma lalo o 12 mau makahiki.ʻO Perampanel ka mua AMPA receptor antagonist e loaʻa ka ʻae FDA ma ke ʻano he AED.Loaʻa ka AMPA glutamate receptors ma luna o nā neurons postsynaptic i ka lolo.Ma ke ʻano he antagonist koho, noncompetitive o AMPA, pale ka parampanel i ka wehe ʻana o ke kahawai ion a hōʻemi i ka hoʻolaha ʻana o ka hiki ke hana.
