N-Ethyl-N-Methylcarbamoyl Chloride CAS 42252-34-6 Rivastigmine Tartrate Ma'ema'e Waena >99.0% (GC)

N-Ethyl-N-Methylcarbamoyl Chloride (Ethyl(methyl)carbamic Chloride) (CAS: 42252-34-6), waena o Rivastigmine Tartrate (CAS: 129101-54-8).ʻO Rivastigmine Tartrate ka tartrate o rivastigmine, he lāʻau lapaʻau no ka mālama ʻana i ka maʻi o Alzheimer.ʻO Rivastigmine kahi physostigmine derivative, i hoʻomohala maikaʻi ʻia no ka manawa mua e Novartis, Switzerland.ʻO ka inoa kālepa he exelon, a he ʻano benzyl carbamate ka mole, ʻo ia ka carbamate brain-cholinesterase inhibitor, hiki ke kāohi i ka acetylcholinesterase a me butyrylcholinesterase i ka manawa like, a hoʻoikaika i ka conduction nerve cholinergic ma ka hoʻopaneʻe ʻana i ka degradation o acetylcholine i hoʻokuʻu ʻia e cholinergic neurons.Hiki iā ia ke hoʻomaikaʻi i ka cognitive dysfunction mediated by cholinergic, ma laila e hoʻomaikaʻi ai i ka hopena cognitive o nā maʻi me ka maʻi o Alzheimer.ʻO ka hiki ke hoʻopaʻa i ka protein plasma o rivastigmine he nāwaliwali, maʻalahi ke hele i ka pale koko-lolo, a he kiʻekiʻe ke koho o ka lolo.ʻAʻole hiki iā ia ke koho wale i nā wahi palupalu o ka cerebral cortex a me ka hippocampus, akā makemake pū kekahi i nā subtypes nui o AChE i loko o ka lolo, hiki ke hōʻemi i nā hopena ʻaoʻao cholinergic peripheral i ka wā e hana ana i nā hopena curative.ʻO ka hapalua o ke ola o ka rivastigmine tartrate i loko o ke kino he pōkole a lōʻihi ka manawa hana.ʻAʻole like me ka tacrine, ʻoi aku ka ikaika o kēia huahana ma ka G1 enzyme i ka hippocampus a me ka cortex.Hoʻohana ʻia ia no ka mālama ʻana i ka maʻi dementia ʻo Alzheimer mai ka haʻahaʻa a haʻahaʻa, ka mea i manaʻo ʻia he maʻi Alzheimer a i ʻole maʻi Alzheimer.