Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-hoʻokahi Maʻemaʻe ≥99.0% (HPLC)

ʻO 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 503615-03-0) ka mea waena no ka synthesis o Apixaban (CAS: 503612-47-3) .
ʻO Apixaban kahi ʻano hou o ka waha Xa factor inhibitor i hoʻomohala pū ʻia e Bristol-Myers Squibb a me Pfizer.ʻO ka inoa kālepa ʻo Eratol, he ʻano hou o ka anticoagulant waha.Ma ke kāohi ʻana i kahi mea coagulation koʻikoʻi Xa, hiki iā Apixaban ke pale i ka hana thrombin a me ka thrombosis.
Ma ʻApelila 26, 2007, hui pū ʻo Bristol-Myers Squibb me Pfizer e hoʻolaha i ka hui pū ʻana i ka hoʻomohala ʻana i kahi anticoagulant waha hou ʻo Apixaban nona Bristol-Myers Squibb ma ke ʻano he mea hou i ka warfarin.Wahi a ka ʻaelike hui, e uku ʻo Pfizer i kahi uku mua o US $0.25 biliona iā Bristol-Myers Squibb e lawe i ka 60% o ka huina hoʻomohala o ka anticoagulant Apixaban (e hoʻokō ʻia mai Ianuali 1, 2007), ʻoiai ʻo Bristol-Myers. E lawe ʻo Squibb i ke koena 40%, no laila e loaʻa ai ke kuleana e hoʻomohala a kūʻai aku i ka lāʻau.
I ka Mei 2011, ʻo Apixaban ka mea mua i ʻae i ka pale ʻana i ka thrombosis venous i nā poʻe maʻi makua e hana ana i ka ʻoki ʻoki ʻāʻī a i ʻole ke kuli ma 27 mau ʻāina EU, Iceland a me Norewai.
Ma ka lā 20 o Nowemapa, 2012, ua ʻae ke Komisina ʻEulopa iā Ererto (Apixaban) no ka pale ʻana i ka hahau a me ka systemic embolism i nā poʻe maʻi makua me ka non-valvular atrial fibrillation (NVAF) me hoʻokahi a ʻoi aku paha nā mea pilikia.Ma hope mai, ua ʻae ka Canadian Food and Drug Administration, Iapana, a me ka US FDA iā Ererto (Apixaban) no ka pale ʻana i ka hahau a me ka systemic embolism i nā poʻe maʻi maʻi me ka non-valvular atrial fibrillation (NVAF) me hoʻokahi a ʻoi aku paha nā mea pilikia.
Ma ʻApelila 12, 2013, ua hoʻolaha ʻia ka lāʻau anticoagulant hou ʻo Eloto (ELIQUIS) (apixaban) i hui pū ʻia e Bristol-Myers Squibb a me Pfizer e hoʻopaʻa inoa ʻia ma Kina.ʻO Ererto kahi mea hoʻopaneʻe oral factor Xa no ka pale ʻana i ka thromboembolism venous (VTE) i nā poʻe maʻi makua e hele ana i ka hip a i ʻole ke kuli.Hāʻawi kāna papa inoa i kahi koho hou palekana a maikaʻi hoʻi no ka anticoagulation lapaʻau ma hope o ke ʻoki orthopedic, a lawe mai i ka nūhou maikaʻi i nā poʻe maʻi Kina e hoʻololi ana i ka hip/knee elective replacement.Ua hōʻoia ʻia nā noiʻi lapaʻau e hoʻohālikelike ʻia me 40mg enoxaparin hoʻokahi manawa i ka lā, 2 mau manawa o ka hoʻohana waha ʻana o Eratol (Apixaban) 2.5mg i ʻoi aku ka maikaʻi no ka pale ʻana i ka thromboembolism venous ma hope o ka hoʻololi ʻana i ka ʻūhā a i ʻole ke kuli, ʻaʻole hoʻonui i ka hopena o ke koko.