5-Amino-3-(Trifluoromethyl)picolinonitrile CAS 573762-62-6 Apalutamide Maʻemaʻe Kūwaena >98.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o 5-Amino-3- (Trifluoromethyl) picolinonitrile (CAS: 573762-62-6) me ke kūlana kiʻekiʻe, waena o Apalutamide (CAS: 956104-40-8).Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai aku i ka Apalutamide Intermediates,Please contact: alvin@ruifuchem.com
| Inoa Kimia | 5-Amino-3-(Trifluoromethyl)picolinonitrile |
| Nā huaʻōlelo like | 5-Amino-3-(Trifluoromethyl)pyridine-2-Carbonitrile;5-Amino-3-(Trifluoromethyl)2-Cyanopyridine;5-Amino-2-Cyano-3-(Trifluoromethyl)pyridine;ʻO ka haumia ʻo Apalutamide 10 |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 573762-62-6 |
| ʻĀpana Molekala | C7H4F3N3 |
| Kaumaha Molecular | 187.12 g/mol |
| ʻO ka mānoanoa | 1.45±0.10 g/cm3 |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Papa Hazard | 6.1 |
| Hui Pūʻulu | Ⅲ |
| Māhele | Waena o Apalutamide (CAS: 956104-40-8) |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Melemele Māmā a Melemele Paʻa | Hoʻokō |
| Wai na Karl Fischer | <0.50% | 0.35% |
| Maʻemaʻe / Kaʻina Hanana | >98.0% (HPLC) | 99.03% |
| Infrared Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
| 1H NMR Spectrum | Kūlike me ka Hoʻolālā | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō me nā kikoʻī i hāʻawi ʻia | |
| Palapala noi | Waena o Apalutamide (CAS: 956104-40-8) | |
Pūʻolo:ʻO ka ʻōmole Fluorinated, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a me ka makani maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
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Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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ʻO 5-Amino-3-(Trifluoromethyl) picolinonitrile (CAS: 573762-62-6), he pyridine heterocyclic organic compound, hiki ke hoʻohana ʻia ma ke ʻano he pharmaceutical intermediates.ʻO 5-Amino-3-(Trifluoromethyl) picolinonitrile kahi waena o Apalutamide (CAS: 956104-40-8).ʻO Apalutamide kahi antiandrogen lua o ka hanauna i hoʻohana ʻia i ka mālama ʻana i ka maʻi maʻi prostate.He antagonist ikaika ia o ka mea hoʻokipa androgen me ka waiwai IC50 o 16 nM.Hoʻopaʻa i nā mea hoʻokipa androgen, no laila ke kāohi nei i ka translocation nuklea, ka paʻa ʻana o DNA a me ka hoʻoulu ʻana i ka transcriptional.Loaʻa i ka Apalutamide nā noi therapeutic i ka maʻi prostate non-metastatic, castration-resistant.
Hoʻohana ʻia ʻo Apalutamide no ka mālama ʻana i kekahi ʻano o ka maʻi maʻi prostate kūʻē i ka castration a i ʻole ka maʻi prostate ʻaʻole i laha i nā wahi ʻē aʻe o ke kino, akā ʻaʻole i kōkua ʻia e nā lāʻau lapaʻau ʻē aʻe.Aia ʻo Apalutamide i kahi papa o nā lāʻau i kapa ʻia ʻo androgen receptor inhibitors.Hana ia ma ka pale ʻana i nā hopena o ka androgen e hoʻōki i ka ulu a me ka hoʻolaha ʻana o nā maʻi maʻi maʻi.Ma Kepakemapa 17, 2019, ua ʻae ka Food and Drug Administration i ka Apalutamide (ERLEADA, Janssen Biotech, Inc) no nā poʻe maʻi me ka maʻi maʻi prostate castration-sensitive prostate (mCSPC).Ua ʻae ʻia ʻo Apalutamide i ka makahiki 2018 no nā mea maʻi me ka maʻi maʻi prostate non-metastatic castration-resistant.
