1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Maʻemaʻe ≥98.0% (HPLC)
ʻO Shanghai Ruifu Chemical Co., Ltd. ka mea hana nui o 1-Boc-4-(4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) me ke kūlana kiʻekiʻe, waena o Crizotinib (CAS: 877399- 52-5).Hiki iā Ruifu Chemical ke hāʻawi aku i ka honua holoʻokoʻa, ke kumukūʻai hoʻokūkū, ka lawelawe maikaʻi loa, ka liʻiliʻi a me ka nui nui i loaʻa.E kūʻai i nā mea waena Crizotinib,Please contact: alvin@ruifuchem.com
| Inoa Kimia | 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine |
| Nā huaʻōlelo like | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl)-4-Bromopyrazole;Crizotinib haumia 4 |
| Kūlana Kūʻai | Ma ke Kahua, Hana Hana Kūʻai |
| Helu CAS | 877399-50-3 |
| ʻĀpana Molekala | C13H20BrN3O2 |
| Kaumaha Molecular | 330.23 g/mol |
| Lae hehee | 77.0 a 81.0 ℃ |
| ʻO ka mānoanoa | 1.43 |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka Methanol |
| COA & MSDS | Loaʻa |
| Ke kumu | Shanghai, Kina |
| Māhele | Kūwaena o Crizotinib (CAS: 877399-52-5) |
| Brand | Kemika Ruifu |
| Nā mea | Nā Kūlana Nānā | Nā hualoaʻa |
| Ka nana aku | Paʻa Keʻokeʻo | Paʻa Keʻokeʻo |
| Lae hehee | 77.0 a 81.0 ℃ | Hoʻokō |
| Wai na Karl Fischer | <0.50% | 0.11% |
| Maʻemaʻe / Kaʻina Hanana | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Kūlike i ka hoʻolālā | Hoʻokō |
| Mass | Kūlike i ka hoʻolālā | Hoʻokō |
| Ka hopena | Ua hoʻāʻo ʻia ka huahana a hoʻokō i nā kikoʻī i hāʻawi ʻia | |
Pūʻolo:ʻO ka ʻōmole, ʻeke ʻeke alumini, 25kg / pahu pahu pahu, a i ʻole e like me ka makemake o ka mea kūʻai aku.
Kūlana mālama:E hoʻopaʻa paʻa i ka pahu a mālama i loko o kahi hale kūʻai maloʻo a maloʻo (2 ~ 8 ℃) a me kahi hale kūʻai maikaʻi mai nā mea like ʻole.E pale i ka malamalama a me ka wai.
Hoʻouna:Hāʻawi i ka honua ma ka lewa, e FedEx / DHL Express.Hāʻawi wikiwiki a hilinaʻi hoʻi.
Pehea e kūʻai ai?E ʻoluʻolu e kelepona maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 mau makahiki ʻike?Loaʻa iā mākou ma mua o 15 mau makahiki o ka ʻike i ka hana ʻana a me ka hoʻokuʻu ʻana aku i kahi ākea ākea o nā intermediates pharmaceutical kiʻekiʻe a i ʻole nā kemika maikaʻi.
Mākeke Nui?E kūʻai aku i ka mākeke kūloko, ʻAmelika ʻĀkau, ʻEulopa, India, Korea, Iapana, Australia, etc.
Nā pono?ʻO ke kūlana kiʻekiʻe, ke kumukūʻai kūpono, nā lawelawe ʻoihana a me ke kākoʻo ʻenehana, ka lawe wikiwiki ʻana.
ʻAno maikaʻiHōʻoiaʻiʻo?Pūnaehana hoʻomalu maikaʻi koʻikoʻi.ʻO nā lako ʻoihana no ka nānā ʻana ʻo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Nā laʻana?Hāʻawi ka hapa nui o nā huahana i nā laʻana manuahi no ka loiloi maikaʻi, pono e uku ʻia ke kumukūʻai e nā mea kūʻai aku.
Hooia Hale Hana?Welina mai ka loiloi hale hana.E ʻoluʻolu e hoʻopaʻa manawa ma mua.
MOQ?ʻAʻohe MOQ.ʻAe ʻia ke kauoha liʻiliʻi.
Manawa Hoʻouna? Inā i loko o ka waihona, ʻekolu lā hoʻouna ʻia.
Kaʻahele?Ma ka Express (FedEx, DHL), ma ka Air, ma ke Kai.
Nā palapala?Ma hope o ka lawelawe kūʻai: COA, MOA, ROS, MSDS, etc.
Hoʻohui Kuʻuna?Hiki ke hāʻawi i nā lawelawe synthesis maʻamau e kūpono i kāu mau pono noiʻi.
Kūkākūkā uku?E hoʻouna mua ʻia ka invoice Proforma ma hope o ka hōʻoia ʻana o ke kauoha, hoʻopili ʻia kā mākou ʻike panakō.Uku e T/T (Telex Transfer), PayPal, Western Union, etc.
Nā hōʻailona pōʻino Xn - ʻino
Nā Code Risk 22 - He pōʻino ke ʻai ʻia
Hoʻohana ʻia ʻo 1-Boc-4-(4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) ma ke ʻano he waena o Crizotinib (CAS: 877399-52-5).ʻO Crizotinib (inoa kālepa Xalkori,) he lāʻau anti-cancer e hana ana ma ke ʻano he ALK (anaplastic lymphoma kinase) a me ROS1 (c-ros oncogene 1) inhibitor, i ʻae ʻia no ka mālama ʻana i kekahi maʻi maʻi maʻi maʻi liʻiliʻi liʻiliʻi (NSCLC) ma US. a me kekahi mau ʻāina ʻē aʻe, a ke hele nei i nā hoʻokolohua lapaʻau e hoʻāʻo ana i kona palekana a me ka pono inanaplastic large cell lymphoma, neuroblastoma, a me nā maʻi maʻi paʻa kiʻekiʻe ʻē aʻe i nā pākeke a me nā keiki.
I ʻAukake 2011, ua ʻae ka FDA o ʻAmelika Hui Pū ʻIa iā Crizotinib (PF- 02341066) no ka mālama ʻana i ka anaplastic lymphoma kinase (ALK) i hoʻonohonoho hou ʻia i ka maʻi maʻi ʻaʻai māmā liʻiliʻi ʻole (NSCLC).ʻO Crizotinib kahi mea hoʻokūkū hoʻokūkū ʻelua ATP o tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) a me ALK (cellular IC50 = 20 nM), ʻo ia mau mea ʻelua mau pahuhopu nui no ka chemotherapy maʻi.I ka wā i hoʻāʻo ʻia ai ʻo Crizotinib no ke koho ʻana me nā kinases ʻē aʻe, ua ʻike ʻia aia nā enzyme IC50 i loko o 100-fold multiples o c-MET no 13 o nā kinase 120 i hoʻāʻo ʻia.I loko o ka cellular assays, ua ʻike ʻia ʻo Crizotinib e kāohi i ka RON (recepteur d'origine nantais) kinase me kahi puka koho koho 10-fold ma luna o c-MET.
